Diverse Roles of NETosis in the Pathogenesis of Lupus

• Published in: Frontiers in immunology Vol. 13; p. 895216
• Main Authors: Wang, Meiying, Ishikawa, Tatsuya, Lai, Yupeng, Nallapothula, Dhiraj, Singh, Ram Raj
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.05.2022
• Subjects: Animals; autoantibody; autoantigen; Autoantigens; Cell Death; Extracellular Traps; Immunology; Inflammation; NETosis; Neutrophils; pathogenesis; self-tolerance; systemic lupus erythematosus; nephritis; clinical implications; pathogenesis; systemic lupus erythematosus; NETosis; autoantibody; self-tolerance; autoantigen

NETosis is a form of neutrophil cell death during which extracellular fibrillary structures composed of cytosolic and granule proteins assembled on scaffolds of decondensed chromatin, called neutrophil extracellular traps (NETs), are released. NETs normally contribute to host immune defense. Accumul...