Newly Diagnosed Multifocal GBM: A Monocentric Experience and Literature Review

• Published in: Current oncology (Toronto) Vol. 29; no. 5; pp. 3472 - 3488
• Main Authors: Baro, Valentina, Cerretti, Giulia, Todoverto, Michela, Della Puppa, Alessandro, Chioffi, Franco, Volpin, Francesco, Causin, Francesco, Busato, Fabio, Fiduccia, Pasquale, Landi, Andrea, d'Avella, Domenico, Zagonel, Vittorina, Denaro, Luca, Lombardi, Giuseppe
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 11.05.2022; MDPI AG
• Subjects: Antineoplastic Agents, Alkylating - therapeutic use; Brain Neoplasms - drug therapy; Brain Neoplasms - therapy; Dacarbazine - therapeutic use; glioblastoma; Humans; Middle Aged; multicentric; multifocal; oncology; Retrospective Studies; surgery; survival; Temozolomide - therapeutic use; multicentric; glioblastoma; oncology; multifocal; survival; surgery

Glioblastomas with multiple foci at presentation (mGBMs) account for 2-35% of all GBMs. mGBMs have limited existing data and no standardized treatment. This study aims to determine their incidence, demographic and clinical features, outcome, and prognostic factors in terms of overall survival. We pe...