Function and Role of Regulatory T Cells in Rheumatoid Arthritis

• Published in: Frontiers in immunology Vol. 12; p. 626193
• Main Authors: Jiang, Qi, Yang, Guocan, Liu, Qi, Wang, Shengjun, Cui, Dawei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.04.2021
• Subjects: autoimmune diseases; immune tolerance; Immunology; rheumatoid arthritis; transcription factor Foxp3; Treg cells; autoimmune diseases; Treg cells; immune tolerance; transcription factor Foxp3; rheumatoid arthritis

Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune diseases is the loss of tolerance to self or harmless antigens. The loss or functional deficiency of key immune cells, reg...