Function and Role of Regulatory T Cells in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune diseases is the loss of tolerance to self or harmless antigens. The loss or functional deficiency of key immune cells, reg...

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Published inFrontiers in immunology Vol. 12; p. 626193
Main Authors Jiang, Qi, Yang, Guocan, Liu, Qi, Wang, Shengjun, Cui, Dawei
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.04.2021
Subjects
autoimmune diseases
immune tolerance
Immunology
rheumatoid arthritis
transcription factor Foxp3
Treg cells
autoimmune diseases
Treg cells
immune tolerance
transcription factor Foxp3
rheumatoid arthritis
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Abstract Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune diseases is the loss of tolerance to self or harmless antigens. The loss or functional deficiency of key immune cells, regulatory T (Treg) cells, has been confirmed in human autoimmune diseases. The pathogenesis of RA is complex, and the dysfunction of Tregs is one of the proposed mechanisms underlying the breakdown of self-tolerance leading to the progression of RA. Treg cells are a vital component of peripheral immune tolerance, and the transcription factor Foxp3 plays a major immunosuppressive role. Clinical treatment for RA mainly utilizes drugs to alleviate the progression of disease and relieve disease activity, and the ideal treatment strategy should be to re-induce self-tolerance before obvious tissue injury. Treg cells are one of the ideal options. This review will introduce the classification, mechanism of action, and characteristics of Treg cells in RA, which provides insights into clinical RA treatment.
AbstractList Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune diseases is the loss of tolerance to self or harmless antigens. The loss or functional deficiency of key immune cells, regulatory T (Treg) cells, has been confirmed in human autoimmune diseases. The pathogenesis of RA is complex, and the dysfunction of Tregs is one of the proposed mechanisms underlying the breakdown of self-tolerance leading to the progression of RA. Treg cells are a vital component of peripheral immune tolerance, and the transcription factor Foxp3 plays a major immunosuppressive role. Clinical treatment for RA mainly utilizes drugs to alleviate the progression of disease and relieve disease activity, and the ideal treatment strategy should be to re-induce self-tolerance before obvious tissue injury. Treg cells are one of the ideal options. This review will introduce the classification, mechanism of action, and characteristics of Treg cells in RA, which provides insights into clinical RA treatment.
Author Jiang, Qi
Yang, Guocan
Wang, Shengjun
Cui, Dawei
Liu, Qi
AuthorAffiliation 3 Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University , Zhenjiang , China
4 Department of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou , China
2 Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University , Zhenjiang , China
1 Department of Blood Transfusion, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine) , Shaoxing , China
AuthorAffiliation_xml – name: 3 Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University , Zhenjiang , China
– name: 2 Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University , Zhenjiang , China
– name: 1 Department of Blood Transfusion, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine) , Shaoxing , China
– name: 4 Department of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou , China
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  givenname: Shengjun
  surname: Wang
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Keywords autoimmune diseases
Treg cells
immune tolerance
transcription factor Foxp3
rheumatoid arthritis
Language English
License Copyright © 2021 Jiang, Yang, Liu, Wang and Cui.
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Reviewed by: Fan Pan, Chinese Academy of Sciences (CAS), China; Anne Cooke, University of Cambridge, United Kingdom
Edited by: Zhiguang Zhou, Central South University, China
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
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Snippet Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with symmetrical polyarthritis as its critical clinical manifestation. The basic...
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SubjectTerms autoimmune diseases
immune tolerance
Immunology
rheumatoid arthritis
transcription factor Foxp3
Treg cells
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Title Function and Role of Regulatory T Cells in Rheumatoid Arthritis
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Volume 12
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