Advances in mass spectrometry driven O-glycoproteomics

• Published in: Biochimica et biophysica acta Vol. 1850; no. 1; pp. 33 - 42
• Main Authors: Levery, Steven B., Steentoft, Catharina, Halim, Adnan, Narimatsu, Yoshiki, Clausen, Henrik, Vakhrushev, Sergey Y.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2015
• Subjects: biomedical research; cell biology; Cell Line; Cell Line, Tumor; ETD; Glycopeptide; glycoproteins; Glycoproteins - metabolism; Glycosylation; Humans; Lectin; mass spectrometry; Mass Spectrometry - methods; Mass Spectrometry - trends; Orbitrap; Polysaccharides - metabolism; Proteome - metabolism; Proteomics - methods; Proteomics - trends; SimpleCell; Site-specific; Site-specific; SimpleCell; Lectin; Orbitrap; ETD; Glycopeptide

Global analyses of proteins and their modifications by mass spectrometry are essential tools in cell biology and biomedical research. Analyses of glycoproteins represent particular challenges and we are only at the beginnings of the glycoproteomic era. Some of the challenges have been overcome with...