Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2

Novel safe, immunogenic, and effective vaccines are needed to control the COVID-19 pandemic, caused by SARS-CoV-2. Here, we describe the safety, robust immunogenicity, and potent efficacy elicited in rhesus macaques by a modified vaccinia virus Ankara (MVA) vector expressing a full-length SARS-CoV-2...

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Published inFrontiers in immunology Vol. 13; p. 845887
Main Authors Mooij, Petra, García-Arriaza, Juan, Pérez, Patricia, Lázaro-Frías, Adrian, Verstrepen, Babs E., Böszörményi, Kinga P., Mortier, Daniella, Fagrouch, Zahra, Kiemenyi-Kayere, Gwendoline, Niphuis, Henk, Acar, Roja Fidel, Meijer, Lisette, Stammes, Marieke A., Kondova, Ivanela, Verschoor, Ernst J., GeurtsvanKessel, Corine H., de Bruin, Erwin, Sikkema, Reina S., Luczkowiak, Joanna, Delgado, Rafael, Montenegro, Dolores, Puentes, Eugenia, Rodríguez, Esteban, Bogers, Willy M. J. M., Koopman, Gerrit, Esteban, Mariano
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.03.2022
Subjects
Animals
Antibodies, Viral
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines
Humans
Immunology
Macaca mulatta
MVA vaccine
Pandemics
rhesus macaques
safety
SARS-CoV-2
SARS-CoV-2 - genetics
spike
Spike Glycoprotein, Coronavirus
Vaccinia virus - genetics
COVID-19
SARS-CoV-2
rhesus macaques
safety
efficacy
immunogenicity
MVA vaccine
spike
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Abstract Novel safe, immunogenic, and effective vaccines are needed to control the COVID-19 pandemic, caused by SARS-CoV-2. Here, we describe the safety, robust immunogenicity, and potent efficacy elicited in rhesus macaques by a modified vaccinia virus Ankara (MVA) vector expressing a full-length SARS-CoV-2 spike (S) protein (MVA-S). MVA-S vaccination was well tolerated and induced S and receptor-binding domain (RBD)-binding IgG antibodies and neutralizing antibodies against SARS-CoV-2 and several variants of concern. S-specific IFNγ, but not IL-4, -producing cells were also elicited. After SARS-CoV-2 challenge, vaccinated animals showed a significant strong reduction of virus loads in bronchoalveolar lavages (BAL) and decreased levels in throat and nasal mucosa. Remarkably, MVA-S also protected macaques from fever and infection-induced cytokine storm. Computed tomography and histological examination of the lungs showed reduced lung pathology in MVA-S-vaccinated animals. These findings favor the use of MVA-S as a potential vaccine for SARS-CoV-2 in clinical trials.
AbstractList Novel safe, immunogenic, and effective vaccines are needed to control the COVID-19 pandemic, caused by SARS-CoV-2. Here, we describe the safety, robust immunogenicity, and potent efficacy elicited in rhesus macaques by a modified vaccinia virus Ankara (MVA) vector expressing a full-length SARS-CoV-2 spike (S) protein (MVA-S). MVA-S vaccination was well tolerated and induced S and receptor-binding domain (RBD)-binding IgG antibodies and neutralizing antibodies against SARS-CoV-2 and several variants of concern. S-specific IFNγ, but not IL-4, -producing cells were also elicited. After SARS-CoV-2 challenge, vaccinated animals showed a significant strong reduction of virus loads in bronchoalveolar lavages (BAL) and decreased levels in throat and nasal mucosa. Remarkably, MVA-S also protected macaques from fever and infection-induced cytokine storm. Computed tomography and histological examination of the lungs showed reduced lung pathology in MVA-S-vaccinated animals. These findings favor the use of MVA-S as a potential vaccine for SARS-CoV-2 in clinical trials.
Novel safe, immunogenic, and effective vaccines are needed to control the COVID-19 pandemic, caused by SARS-CoV-2. Here, we describe the safety, robust immunogenicity, and potent efficacy elicited in rhesus macaques by a modified vaccinia virus Ankara (MVA) vector expressing a full-length SARS-CoV-2 spike (S) protein (MVA-S). MVA-S vaccination was well tolerated and induced S and receptor-binding domain (RBD)-binding IgG antibodies and neutralizing antibodies against SARS-CoV-2 and several variants of concern. S-specific IFNγ, but not IL-4, -producing cells were also elicited. After SARS-CoV-2 challenge, vaccinated animals showed a significant strong reduction of virus loads in bronchoalveolar lavages (BAL) and decreased levels in throat and nasal mucosa. Remarkably, MVA-S also protected macaques from fever and infection-induced cytokine storm. Computed tomography and histological examination of the lungs showed reduced lung pathology in MVA-S-vaccinated animals. These findings favor the use of MVA-S as a potential vaccine for SARS-CoV-2 in clinical trials.Novel safe, immunogenic, and effective vaccines are needed to control the COVID-19 pandemic, caused by SARS-CoV-2. Here, we describe the safety, robust immunogenicity, and potent efficacy elicited in rhesus macaques by a modified vaccinia virus Ankara (MVA) vector expressing a full-length SARS-CoV-2 spike (S) protein (MVA-S). MVA-S vaccination was well tolerated and induced S and receptor-binding domain (RBD)-binding IgG antibodies and neutralizing antibodies against SARS-CoV-2 and several variants of concern. S-specific IFNγ, but not IL-4, -producing cells were also elicited. After SARS-CoV-2 challenge, vaccinated animals showed a significant strong reduction of virus loads in bronchoalveolar lavages (BAL) and decreased levels in throat and nasal mucosa. Remarkably, MVA-S also protected macaques from fever and infection-induced cytokine storm. Computed tomography and histological examination of the lungs showed reduced lung pathology in MVA-S-vaccinated animals. These findings favor the use of MVA-S as a potential vaccine for SARS-CoV-2 in clinical trials.
Author Montenegro, Dolores
Esteban, Mariano
Bogers, Willy M. J. M.
Delgado, Rafael
Puentes, Eugenia
Niphuis, Henk
Koopman, Gerrit
Acar, Roja Fidel
Kiemenyi-Kayere, Gwendoline
Kondova, Ivanela
Rodríguez, Esteban
Fagrouch, Zahra
de Bruin, Erwin
Verstrepen, Babs E.
Lázaro-Frías, Adrian
Stammes, Marieke A.
Mortier, Daniella
Pérez, Patricia
GeurtsvanKessel, Corine H.
Mooij, Petra
Verschoor, Ernst J.
Luczkowiak, Joanna
García-Arriaza, Juan
Meijer, Lisette
Böszörményi, Kinga P.
Sikkema, Reina S.
AuthorAffiliation 1 Department of Virology, Biomedical Primate Research Centre (BPRC) , Rijswijk , Netherlands
5 Animal Science Department, Biomedical Primate Research Centre (BPRC) , Rijswijk , Netherlands
8 Department of Medicine, Universidad Complutense School of Medicine , Madrid , Spain
4 Department of Parasitology, Biomedical Primate Research Centre (BPRC) , Rijswijk , Netherlands
6 Department of Viroscience, Erasmus Medical Center (MC) , Rotterdam , Netherlands
9 Biofabri , O Porriño , Spain
3 Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC) , Madrid , Spain
2 Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC) , Madrid , Spain
7 Instituto de Investigación Hospital Universitario 12 de Octubre (imas12) , Madrid , Spain
AuthorAffiliation_xml – name: 4 Department of Parasitology, Biomedical Primate Research Centre (BPRC) , Rijswijk , Netherlands
– name: 7 Instituto de Investigación Hospital Universitario 12 de Octubre (imas12) , Madrid , Spain
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– name: 3 Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC) , Madrid , Spain
– name: 5 Animal Science Department, Biomedical Primate Research Centre (BPRC) , Rijswijk , Netherlands
– name: 8 Department of Medicine, Universidad Complutense School of Medicine , Madrid , Spain
– name: 2 Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC) , Madrid , Spain
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ContentType Journal Article
Copyright Copyright © 2022 Mooij, García-Arriaza, Pérez, Lázaro-Frías, Verstrepen, Böszörményi, Mortier, Fagrouch, Kiemenyi-Kayere, Niphuis, Acar, Meijer, Stammes, Kondova, Verschoor, GeurtsvanKessel, de Bruin, Sikkema, Luczkowiak, Delgado, Montenegro, Puentes, Rodríguez, Bogers, Koopman and Esteban.
Copyright © 2022 Mooij, García-Arriaza, Pérez, Lázaro-Frías, Verstrepen, Böszörményi, Mortier, Fagrouch, Kiemenyi-Kayere, Niphuis, Acar, Meijer, Stammes, Kondova, Verschoor, GeurtsvanKessel, de Bruin, Sikkema, Luczkowiak, Delgado, Montenegro, Puentes, Rodríguez, Bogers, Koopman and Esteban 2022 Mooij, García-Arriaza, Pérez, Lázaro-Frías, Verstrepen, Böszörményi, Mortier, Fagrouch, Kiemenyi-Kayere, Niphuis, Acar, Meijer, Stammes, Kondova, Verschoor, GeurtsvanKessel, de Bruin, Sikkema, Luczkowiak, Delgado, Montenegro, Puentes, Rodríguez, Bogers, Koopman and Esteban
Copyright_xml – notice: Copyright © 2022 Mooij, García-Arriaza, Pérez, Lázaro-Frías, Verstrepen, Böszörményi, Mortier, Fagrouch, Kiemenyi-Kayere, Niphuis, Acar, Meijer, Stammes, Kondova, Verschoor, GeurtsvanKessel, de Bruin, Sikkema, Luczkowiak, Delgado, Montenegro, Puentes, Rodríguez, Bogers, Koopman and Esteban.
– notice: Copyright © 2022 Mooij, García-Arriaza, Pérez, Lázaro-Frías, Verstrepen, Böszörményi, Mortier, Fagrouch, Kiemenyi-Kayere, Niphuis, Acar, Meijer, Stammes, Kondova, Verschoor, GeurtsvanKessel, de Bruin, Sikkema, Luczkowiak, Delgado, Montenegro, Puentes, Rodríguez, Bogers, Koopman and Esteban 2022 Mooij, García-Arriaza, Pérez, Lázaro-Frías, Verstrepen, Böszörményi, Mortier, Fagrouch, Kiemenyi-Kayere, Niphuis, Acar, Meijer, Stammes, Kondova, Verschoor, GeurtsvanKessel, de Bruin, Sikkema, Luczkowiak, Delgado, Montenegro, Puentes, Rodríguez, Bogers, Koopman and Esteban
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Keywords COVID-19
SARS-CoV-2
rhesus macaques
safety
efficacy
immunogenicity
MVA vaccine
spike
Language English
License Copyright © 2022 Mooij, García-Arriaza, Pérez, Lázaro-Frías, Verstrepen, Böszörményi, Mortier, Fagrouch, Kiemenyi-Kayere, Niphuis, Acar, Meijer, Stammes, Kondova, Verschoor, GeurtsvanKessel, de Bruin, Sikkema, Luczkowiak, Delgado, Montenegro, Puentes, Rodríguez, Bogers, Koopman and Esteban.
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Edited by: Arun Kumar, Coalition for Epidemic Preparedness Innovations (CEPI), Norway
These authors have contributed equally to this work and share first authorship
This article was submitted to Vaccines and Molecular Therapeutics, a section of the journal Frontiers in Immunology
Reviewed by: Shailendra Mani, Translational Health Science and Technology Institute (THSTI), India; Luka Cicin-Sain, Helmholtz Association of German Research Centers (HZ), Germany
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Snippet Novel safe, immunogenic, and effective vaccines are needed to control the COVID-19 pandemic, caused by SARS-CoV-2. Here, we describe the safety, robust...
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StartPage 845887
SubjectTerms Animals
Antibodies, Viral
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines
Humans
Immunology
Macaca mulatta
MVA vaccine
Pandemics
rhesus macaques
safety
SARS-CoV-2
SARS-CoV-2 - genetics
spike
Spike Glycoprotein, Coronavirus
Vaccinia virus - genetics
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Title Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2
URI https://www.ncbi.nlm.nih.gov/pubmed/35371043
https://www.proquest.com/docview/2646942509
https://pubmed.ncbi.nlm.nih.gov/PMC8966779
https://doaj.org/article/1502963789df47ebbf7ca3cdec8cf7a0
Volume 13
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