Alpha 1 Antitrypsin-Deficient Macrophages Have Impaired Efferocytosis of Apoptotic Neutrophils

• Published in: Frontiers in immunology Vol. 11; p. 574410
• Main Authors: Lee, Jungnam, Lu, Yuanqing, Oshins, Regina, West, Jesse, Moneypenny, Craig G, Han, Kyudong, Brantly, Mark L
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.11.2020
• Subjects: AAT deficiency; Alpha 1 antitrysin; alpha 1-Antitrypsin - genetics; alpha 1-Antitrypsin - immunology; alpha 1-Antitrypsin Deficiency - genetics; alpha 1-Antitrypsin Deficiency - immunology; Apoptosis - immunology; Chemotaxis, Leukocyte; cytokine; Cytokines - metabolism; efferocytosis; Genotype; Humans; Immunology; Lipopolysaccharides - pharmacology; macrophage; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; neutrophil; Neutrophils - immunology; Neutrophils - metabolism; Phagocytosis - drug effects; Phagocytosis - genetics; Phagocytosis - immunology; Tumor Necrosis Factor-alpha - immunology; Tumor Necrosis Factor-alpha - metabolism; cytokine; macrophage; Alpha 1 antitrysin; neutrophil; AAT deficiency; efferocytosis

Alpha 1 antitrypsin deficiency (AATD) is an autosomal co-dominant disorder characterized by a low level of circulating AAT, which significantly reduces protection for the lower airways against proteolytic burden caused by neutrophils. Neutrophils, which are terminally differentiated innate immune ce...