Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases

• Published in: JCI insight Vol. 1; no. 9
• Main Authors: Liu, Gang, Cooley, Marion A, Jarnicki, Andrew G, Hsu, Alan C-Y, Nair, Prema M, Haw, Tatt Jhong, Fricker, Michael, Gellatly, Shaan L, Kim, Richard Y, Inman, Mark D, Tjin, Gavin, Wark, Peter A B, Walker, Marjorie M, Horvat, Jay C, Oliver, Brian G, Argraves, W Scott, Knight, Darryl A, Burgess, Janette K, Hansbro, Philip M
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 16.06.2016

Airway and/or lung remodeling, involving exaggerated extracellular matrix (ECM) protein deposition, is a critical feature common to pulmonary diseases including chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary fibrosis (IPF). Fibulin-1 (Fbln1), an important ECM protein...