Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases
Airway and/or lung remodeling, involving exaggerated extracellular matrix (ECM) protein deposition, is a critical feature common to pulmonary diseases including chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary fibrosis (IPF). Fibulin-1 (Fbln1), an important ECM protein...
Saved in:
| Published in | JCI insight Vol. 1; no. 9 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Society for Clinical Investigation
16.06.2016
|
| Online Access | Get full text |
Cover
Loading…
| Abstract | Airway and/or lung remodeling, involving exaggerated extracellular matrix (ECM) protein deposition, is a critical feature common to pulmonary diseases including chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary fibrosis (IPF). Fibulin-1 (Fbln1), an important ECM protein involved in matrix organization, may be involved in the pathogenesis of these diseases. We found that Fbln1 was increased in COPD patients and in cigarette smoke-induced (CS-induced) experimental COPD in mice. Genetic or therapeutic inhibition of
protected against CS-induced airway fibrosis and emphysema-like alveolar enlargement. In experimental COPD, this occurred through disrupted collagen organization and interactions with fibronectin, periostin, and tenascin-c. Genetic inhibition of
also reduced levels of pulmonary inflammatory cells and proinflammatory cytokines/chemokines (TNF-α, IL-33, and CXCL1) in experimental COPD.
mice also had reduced airway remodeling in experimental chronic asthma and pulmonary fibrosis. Our data show that Fbln1c may be a therapeutic target in chronic respiratory diseases. |
|---|---|
| AbstractList | Airway and/or lung remodeling, involving exaggerated extracellular matrix (ECM) protein deposition, is a critical feature common to pulmonary diseases including chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary fibrosis (IPF). Fibulin-1 (Fbln1), an important ECM protein involved in matrix organization, may be involved in the pathogenesis of these diseases. We found that Fbln1 was increased in COPD patients and in cigarette smoke-induced (CS-induced) experimental COPD in mice. Genetic or therapeutic inhibition of
protected against CS-induced airway fibrosis and emphysema-like alveolar enlargement. In experimental COPD, this occurred through disrupted collagen organization and interactions with fibronectin, periostin, and tenascin-c. Genetic inhibition of
also reduced levels of pulmonary inflammatory cells and proinflammatory cytokines/chemokines (TNF-α, IL-33, and CXCL1) in experimental COPD.
mice also had reduced airway remodeling in experimental chronic asthma and pulmonary fibrosis. Our data show that Fbln1c may be a therapeutic target in chronic respiratory diseases. Airway and/or lung remodeling, involving exaggerated extracellular matrix (ECM) protein deposition, is a critical feature common to pulmonary diseases including chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary fibrosis (IPF). Fibulin-1 (Fbln1), an important ECM protein involved in matrix organization, may be involved in the pathogenesis of these diseases. We found that Fbln1 was increased in COPD patients and in cigarette smoke-induced (CS-induced) experimental COPD in mice. Genetic or therapeutic inhibition of Fbln1c protected against CS-induced airway fibrosis and emphysema-like alveolar enlargement. In experimental COPD, this occurred through disrupted collagen organization and interactions with fibronectin, periostin, and tenascin-c. Genetic inhibition of Fbln1c also reduced levels of pulmonary inflammatory cells and proinflammatory cytokines/chemokines (TNF-α, IL-33, and CXCL1) in experimental COPD. Fbln1c-/- mice also had reduced airway remodeling in experimental chronic asthma and pulmonary fibrosis. Our data show that Fbln1c may be a therapeutic target in chronic respiratory diseases. Airway and/or lung remodeling, involving exaggerated extracellular matrix (ECM) protein deposition, is a critical feature common to pulmonary diseases including chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary fibrosis (IPF). Fibulin-1 (Fbln1), an important ECM protein involved in matrix organization, may be involved in the pathogenesis of these diseases. We found that Fbln1 was increased in COPD patients and in cigarette smoke–induced (CS-induced) experimental COPD in mice. Genetic or therapeutic inhibition of Fbln1c protected against CS-induced airway fibrosis and emphysema-like alveolar enlargement. In experimental COPD, this occurred through disrupted collagen organization and interactions with fibronectin, periostin, and tenascin-c. Genetic inhibition of Fbln1c also reduced levels of pulmonary inflammatory cells and proinflammatory cytokines/chemokines (TNF-α, IL-33, and CXCL1) in experimental COPD. Fbln1c –/– mice also had reduced airway remodeling in experimental chronic asthma and pulmonary fibrosis. Our data show that Fbln1c may be a therapeutic target in chronic respiratory diseases. The extracellular matrix protein fibulin-1 may be a therapeutic target of tissue remodelling and inflammation in chronic respiratory diseases. |
| Author | Liu, Gang Inman, Mark D Argraves, W Scott Kim, Richard Y Hansbro, Philip M Fricker, Michael Cooley, Marion A Jarnicki, Andrew G Horvat, Jay C Burgess, Janette K Walker, Marjorie M Hsu, Alan C-Y Haw, Tatt Jhong Knight, Darryl A Wark, Peter A B Oliver, Brian G Nair, Prema M Gellatly, Shaan L Tjin, Gavin |
| AuthorAffiliation | 9 Department of Pathology and Medical Biology, University of Groningen, University Medical Center, Groningen, Netherlands 8 Discipline of Pharmacology, Sydney Medical School, The University of Sydney, New South Wales, Australia 1 Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia 4 Woolcock Institute of Medical Research, Discipline of Pharmacology, The University of Sydney, Sydney, New South Wales, Australia 2 Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, USA 5 Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia 7 Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia, Canada 3 Division of Respirology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada 6 School of Life Sciences, The Univers |
| AuthorAffiliation_xml | – name: 2 Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, USA – name: 4 Woolcock Institute of Medical Research, Discipline of Pharmacology, The University of Sydney, Sydney, New South Wales, Australia – name: 8 Discipline of Pharmacology, Sydney Medical School, The University of Sydney, New South Wales, Australia – name: 3 Division of Respirology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada – name: 6 School of Life Sciences, The University of Technology, Sydney, New South Wales, Australia – name: 1 Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia – name: 9 Department of Pathology and Medical Biology, University of Groningen, University Medical Center, Groningen, Netherlands – name: 7 Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia, Canada – name: 5 Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia |
| Author_xml | – sequence: 1 givenname: Gang surname: Liu fullname: Liu, Gang organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia – sequence: 2 givenname: Marion A surname: Cooley fullname: Cooley, Marion A organization: Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, USA – sequence: 3 givenname: Andrew G surname: Jarnicki fullname: Jarnicki, Andrew G organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia – sequence: 4 givenname: Alan C-Y surname: Hsu fullname: Hsu, Alan C-Y organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia – sequence: 5 givenname: Prema M surname: Nair fullname: Nair, Prema M organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia – sequence: 6 givenname: Tatt Jhong surname: Haw fullname: Haw, Tatt Jhong organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia – sequence: 7 givenname: Michael surname: Fricker fullname: Fricker, Michael organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia – sequence: 8 givenname: Shaan L surname: Gellatly fullname: Gellatly, Shaan L organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia – sequence: 9 givenname: Richard Y surname: Kim fullname: Kim, Richard Y organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia – sequence: 10 givenname: Mark D surname: Inman fullname: Inman, Mark D organization: Division of Respirology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada – sequence: 11 givenname: Gavin surname: Tjin fullname: Tjin, Gavin organization: Woolcock Institute of Medical Research, Discipline of Pharmacology, The University of Sydney, Sydney, New South Wales, Australia – sequence: 12 givenname: Peter A B surname: Wark fullname: Wark, Peter A B organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia – sequence: 13 givenname: Marjorie M surname: Walker fullname: Walker, Marjorie M organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia – sequence: 14 givenname: Jay C surname: Horvat fullname: Horvat, Jay C organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia – sequence: 15 givenname: Brian G surname: Oliver fullname: Oliver, Brian G organization: Woolcock Institute of Medical Research, Discipline of Pharmacology, The University of Sydney, Sydney, New South Wales, Australia; School of Life Sciences, The University of Technology, Sydney, New South Wales, Australia – sequence: 16 givenname: W Scott surname: Argraves fullname: Argraves, W Scott organization: Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, USA – sequence: 17 givenname: Darryl A surname: Knight fullname: Knight, Darryl A organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia; Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia, Canada – sequence: 18 givenname: Janette K surname: Burgess fullname: Burgess, Janette K organization: Woolcock Institute of Medical Research, Discipline of Pharmacology, The University of Sydney, Sydney, New South Wales, Australia; Discipline of Pharmacology, Sydney Medical School, The University of Sydney, New South Wales, Australia; Department of Pathology and Medical Biology, University of Groningen, University Medical Center, Groningen, Netherlands – sequence: 19 givenname: Philip M surname: Hansbro fullname: Hansbro, Philip M organization: Priority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27398409$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVUU1r3DAQFWFDkib5AbkEH3vZjb5sS5dCWZo2EAiB3IVsj7xavNJWIxfy76sk2yWFgZlh3nszzPtCFiEGIOSG0RVjLb_b9n7lA_pxk1eqEYqekAsuWr0ULVWLT_U5uUbcUkpZKzmt1Rk5563QSlJ9QZ7vfTdPPixZlWCcJ5sBq7yBam_zJo4QAD1W0VXZI85QQLs4QCGMlQ-lw71PNsf0Wg0ewSLgFTl1dkK4PuRL8nL_42X9a_n49PNh_f1x2cumzuUyq-uulj2XViqrueycEgNjHS81161s3DA4LXrW1b1tpZO6Flo4Ll3Dqbgk3z5k93O3g6GHkJOdzD75nU2vJlpv_p8EvzFj_GOkFo3iogh8PQik-HsGzGbnsYdpsgHijIYp3rRMlihQ9gHtU0RM4I5rGDVvZphihjmYYd7NKJzbz_cdGf9eL_4CSouLyA |
| CitedBy_id | crossref_primary_10_3389_fphar_2021_645858 crossref_primary_10_3390_ijms25105108 crossref_primary_10_1016_j_cca_2018_04_038 crossref_primary_10_1080_14728214_2020_1819982 crossref_primary_10_1002_path_5401 crossref_primary_10_1038_s41385_020_00340_z crossref_primary_10_1164_rccm_202205_0848OC crossref_primary_10_3389_fimmu_2018_02432 crossref_primary_10_1007_s11010_019_03501_2 crossref_primary_10_3389_fcell_2022_1073320 crossref_primary_10_3389_fmed_2020_00191 crossref_primary_10_1096_fj_201901779R crossref_primary_10_3389_fphar_2023_1081724 crossref_primary_10_3390_ijms19092787 crossref_primary_10_1183_16000617_0250_2021 crossref_primary_10_1002_JLB_3AB0518_178R crossref_primary_10_1161_ATVBAHA_120_314013 crossref_primary_10_1183_16000617_0096_2019 crossref_primary_10_2217_nnm_2021_0016 crossref_primary_10_1186_s12885_020_6686_x crossref_primary_10_1038_s41385_019_0163_3 crossref_primary_10_1172_jci_insight_94040 crossref_primary_10_1183_16000617_0185_2019 crossref_primary_10_1183_16000617_0202_2021 crossref_primary_10_1165_rcmb_2017_0242OC crossref_primary_10_3389_fmed_2020_00554 crossref_primary_10_1038_s41598_021_97091_z crossref_primary_10_1016_j_ajpath_2018_03_016 crossref_primary_10_1183_13993003_01340_2019 crossref_primary_10_1111_cea_13766 crossref_primary_10_1183_13993003_00174_2018 crossref_primary_10_1016_j_matbio_2018_03_012 crossref_primary_10_1016_j_pharmthera_2021_107839 crossref_primary_10_1155_2022_4809415 crossref_primary_10_3390_ijms23052408 crossref_primary_10_1007_s43152_021_00031_2 crossref_primary_10_3390_vaccines11030529 crossref_primary_10_1164_rccm_202009_3442OC crossref_primary_10_1002_med_21956 crossref_primary_10_1016_j_jos_2020_12_006 crossref_primary_10_1172_JCI98224 crossref_primary_10_1183_13993003_01431_2021 crossref_primary_10_1172_jci_insight_90443 crossref_primary_10_3389_fcvm_2021_674498 crossref_primary_10_1111_resp_12971 crossref_primary_10_1152_ajpcell_00162_2022 crossref_primary_10_1016_j_celrep_2023_112525 crossref_primary_10_1002_path_4979 crossref_primary_10_1007_s00056_022_00410_w crossref_primary_10_1038_s41374_018_0146_0 crossref_primary_10_1038_s41598_017_11450_3 crossref_primary_10_1038_s41467_023_42913_z crossref_primary_10_1038_cti_2017_6 crossref_primary_10_3389_fphar_2017_00503 crossref_primary_10_2147_JIR_S402734 crossref_primary_10_3389_fimmu_2018_00670 crossref_primary_10_1016_j_jaci_2022_04_032 crossref_primary_10_3389_fonc_2021_754240 crossref_primary_10_1016_j_matbio_2017_12_004 crossref_primary_10_1183_23120541_00658_2020 crossref_primary_10_1016_j_pharmthera_2021_107941 crossref_primary_10_1038_s41598_017_13888_x crossref_primary_10_3389_fcell_2021_789716 crossref_primary_10_1016_j_ebiom_2020_103192 crossref_primary_10_1016_j_pharmthera_2017_04_001 crossref_primary_10_1186_s12890_019_0786_x crossref_primary_10_1126_scitranslmed_aav7223 crossref_primary_10_1186_s12931_022_02298_x crossref_primary_10_1002_path_5632 crossref_primary_10_1152_ajplung_00232_2022 crossref_primary_10_3390_ijms24010252 crossref_primary_10_1016_j_jaci_2023_09_035 crossref_primary_10_1089_gtmb_2020_0274 crossref_primary_10_1016_j_redox_2020_101720 crossref_primary_10_1097_MD_0000000000037421 crossref_primary_10_1111_imcb_12537 crossref_primary_10_1126_scitranslmed_aaw9009 crossref_primary_10_1002_cti2_1084 crossref_primary_10_1016_j_compbiomed_2023_107597 crossref_primary_10_1172_jci_insight_124529 crossref_primary_10_1016_j_biopha_2023_114909 crossref_primary_10_1016_j_jare_2023_01_018 crossref_primary_10_1186_s12014_024_09459_8 |
| Cites_doi | 10.1371/journal.pone.0091996 10.1038/mi.2015.104 10.1056/NEJMoa1014350 10.1172/JCI60324 10.1038/ni.2913 10.1128/MCB.21.20.7025-7034.2001 10.1002/ijc.2910200102 10.1164/ajrccm.161.2.9902094 10.1165/rcmb.2007-0367OC 10.1038/sj.cr.7290318 10.1016/j.clim.2013.12.003 10.1002/art.24620 10.1038/nrm1130 10.1016/0091-6749(91)90189-U 10.1164/ajrccm.163.5.2101039 10.1517/17460441.2014.909805 10.1016/0003-9969(76)90043-1 10.1164/rccm.200706-958OC 10.1371/journal.pone.0065544 10.1074/jbc.M114.548594 10.1016/j.cell.2010.03.015 10.1183/09031936.06.00078405 10.1046/j.1523-1747.1999.00802.x 10.1083/jcb.111.6.3155 10.1074/jbc.272.36.22600 10.1038/nm.3049 10.1016/0003-9861(61)90291-0 10.1016/j.vaccine.2007.09.034 10.1091/mbc.E08-06-0621 10.1371/journal.ppat.1004549 10.1164/rccm.201501-0188OC 10.1016/S0021-9258(19)88674-X 10.1016/j.jaci.2009.10.018 10.1152/ajplung.00298.2004 10.1016/j.ab.2012.10.010 10.1371/journal.pone.0013360 10.1038/nm.1987 10.1038/nri2852 10.1002/jcb.21224 10.1016/j.jaci.2014.05.029 10.1074/mcp.M111.014647 10.1038/srep09496 10.1016/j.immuni.2015.02.011 10.1016/j.jaci.2012.11.053 10.1111/j.1432-1033.1996.0427h.x 10.1016/j.jaci.2013.04.012 10.1038/nrd3810 10.1038/mi.2011.55 10.1038/mi.2015.111 10.1378/chest.13-2688 10.1186/1465-9921-9-83 10.1016/j.matbio.2015.01.016 10.1165/rcmb.2010-0157OC 10.1038/onc.2014.52 10.4049/jimmunol.0901575 10.1111/cea.12218 10.2147/COPD.S52478 10.1242/jcs.114.24.4587 10.1016/j.cell.2011.01.014 10.1016/j.jaci.2009.02.032 10.1177/43.4.7534784 10.1172/JCI104030 10.1016/j.ydbio.2008.04.029 10.1152/ajplung.00385.2009 10.1513/pats.200905-029DS 10.4049/jimmunol.177.2.1272 |
| ContentType | Journal Article |
| Copyright | Copyright © 2016, American Society for Clinical Investigation 2016 American Society for Clinical Investigation |
| Copyright_xml | – notice: Copyright © 2016, American Society for Clinical Investigation 2016 American Society for Clinical Investigation |
| DBID | NPM AAYXX CITATION 7X8 5PM |
| DOI | 10.1172/jci.insight.86380 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2379-3708 |
| ExternalDocumentID | 10_1172_jci_insight_86380 27398409 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NCRR NIH HHS grantid: P20 RR016434 – fundername: NIDCR NIH HHS grantid: R03 DE025309 – fundername: NIGMS NIH HHS grantid: P20 GM103499 – fundername: NHLBI NIH HHS grantid: R01 HL095067 |
| GroupedDBID | 53G AAFWJ ADBBV AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS GROUPED_DOAJ HYE M~E NPM OK1 RPM AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c465t-37a95b54c24a48a924bf83d11b292429746fddf93c1b5ca74f495393f24f6203 |
| IEDL.DBID | RPM |
| ISSN | 2379-3708 |
| IngestDate | Thu Jul 06 23:03:29 EDT 2023 Thu Apr 11 18:15:13 EDT 2024 Fri Aug 23 02:30:00 EDT 2024 Wed Jun 21 02:26:55 EDT 2023 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c465t-37a95b54c24a48a924bf83d11b292429746fddf93c1b5ca74f495393f24f6203 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Authorship note: G. Liu, M.A. Cooley, and A.G. Jarnicki contributed equally to this work. W. Scott Argraves is deceased. |
| OpenAccessLink | http://insight.jci.org/articles/view/86380/files/pdf |
| PMID | 27398409 |
| PQID | 1826714714 |
| PQPubID | 23479 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4936823 proquest_miscellaneous_1826714714 crossref_primary_10_1172_jci_insight_86380 pubmed_primary_27398409 |
| PublicationCentury | 2000 |
| PublicationDate | 2016-Jun-16 2016-6-16 20160616 |
| PublicationDateYYYYMMDD | 2016-06-16 |
| PublicationDate_xml | – month: 06 year: 2016 text: 2016-Jun-16 day: 16 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | JCI insight |
| PublicationTitleAlternate | JCI Insight |
| PublicationYear | 2016 |
| Publisher | American Society for Clinical Investigation |
| Publisher_xml | – name: American Society for Clinical Investigation |
| References | 1068660 - Arch Oral Biol. 1976;21(4):251-5 11564885 - Mol Cell Biol. 2001 Oct;21(20):7025-34 10673209 - Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):627-35 11316667 - Am J Respir Crit Care Med. 2001 Apr;163(5):1256-76 20705938 - Am J Respir Cell Mol Biol. 2011 Jun;44(6):906-13 21612469 - N Engl J Med. 2011 May 26;364(21):2006-15 15636647 - Respir Care. 2005 Jan;50(1):78-98; discussion 98-9 23380220 - J Allergy Clin Immunol. 2013 Mar;131(3):752-62 19561617 - Nat Med. 2009 Jul;15(7):774-80 25751541 - Am J Respir Crit Care Med. 2015 May 1;191(9):1012-23 25894560 - PLoS Pathog. 2015 Apr 20;11(4):e1004549 10594729 - J Invest Dermatol. 1999 Dec;113(6):906-12 1955640 - J Allergy Clin Immunol. 1991 Nov;88(5):808-14 21335239 - Cell. 2011 Feb 18;144(4):577-89 25214779 - Int J Chron Obstruct Pulmon Dis. 2014 Sep 01;9:927-32 7534784 - J Histochem Cytochem. 1995 Apr;43(4):401-11 20122715 - J Allergy Clin Immunol. 2010 Mar;125(3):617-25, 625.e1-625.e6 18723441 - Am J Respir Cell Mol Biol. 2009 Mar;40(3):268-76 22089028 - Mucosal Immunol. 2012 Jan;5(1):7-18 23085117 - Anal Biochem. 2013 Feb 15;433(2):105-11 17226767 - J Cell Biochem. 2007 Jun 1;101(3):695-711 14432825 - J Clin Invest. 1960 Jan;39:8-14 17950502 - Vaccine. 2007 Nov 23;25(48):8154-62 23759184 - J Allergy Clin Immunol. 2013 Sep;132(3):676-685.e13 9278415 - J Biol Chem. 1997 Sep 5;272(36):22600-6 25834989 - Sci Rep. 2015 Apr 02;5:9496 23762390 - PLoS One. 2013 Jun 07;8(6):e65544 15591413 - Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L683-91 903179 - Int J Cancer. 1977 Jul 15;20(1):1-5 22159717 - Mol Cell Proteomics. 2012 Apr;11(4):M111.014647 24821729 - J Biol Chem. 2014 Jun 27;289(26):18214-27 24996263 - J Allergy Clin Immunol. 2014 Dec;134(6):1433-42 25786179 - Immunity. 2015 Mar 17;42(3):566-79 24637581 - PLoS One. 2014 Mar 17;9(3):e91996 19841166 - J Immunol. 2009 Nov 15;183(10 ):6469-77 22850885 - J Clin Invest. 2012 Aug;122(8):2749-55 24832167 - Chest. 2014 Oct;146(4):1055-63 19565505 - Arthritis Rheum. 2009 Jul;60(7):2142-55 20833777 - Am J Physiol Lung Cell Mol Physiol. 2010 Dec;299(6):L785-93 24632605 - Oncogene. 2015 Feb 19;34(8):1006-18 16818787 - J Immunol. 2006 Jul 15;177(2):1272-81 20967215 - PLoS One. 2010 Oct 13;5(10):e13360 11792823 - J Cell Sci. 2001 Dec;114(Pt 24):4587-98 20371345 - Cell. 2010 Apr 2;141(1):52-67 16045811 - Cell Res. 2005 Jul;15(7):483-94 23000686 - Nat Rev Drug Discov. 2012 Oct;11(10):790-811 12778127 - Nat Rev Mol Cell Biol. 2003 Jun;4(6):479-89 19361849 - J Allergy Clin Immunol. 2009 May;123(5):1090-7, 1097.e1 23334847 - Nat Med. 2013 Feb;19(2):232-7 13786180 - Arch Biochem Biophys. 1961 May;93:440-7 25636538 - Matrix Biol. 2015 May-Jul;44-46:122-9 19741267 - Proc Am Thorac Soc. 2009 Sep 15;6(6):546-9 26509876 - Mucosal Immunol. 2016 May;9(3):809-20 24952505 - Nat Immunol. 2014 Aug;15(8):727-37 18538758 - Dev Biol. 2008 Jul 15;319(2):336-45 19087346 - Respir Res. 2008 Dec 16;9:83 16707515 - Eur Respir J. 2006 Sep;28(3):533-41 26555706 - Mucosal Immunol. 2016 Jul;9(4):859-72 18174546 - Am J Respir Crit Care Med. 2008 Mar 15;177(6):593-603 20865019 - Nat Rev Immunol. 2010 Oct;10(10):712-23 19109427 - Mol Biol Cell. 2009 Feb;20(4):1141-9 24131248 - Clin Exp Allergy. 2014 Jan;44(1):91-101 24754714 - Expert Opin Drug Discov. 2014 Jun;9(6):629-45 2269669 - J Cell Biol. 1990 Dec;111(6 Pt 2):3155-64 24503171 - Clin Immunol. 2014 Mar;151(1):1-15 8841408 - Eur J Biochem. 1996 Sep 1;240(2):427-34 1400330 - J Biol Chem. 1992 Oct 5;267(28):20120-5 B20 B21 Zandvoort (B28) 2008; 9 B22 B66 B23 B67 B24 B25 B26 B27 B29 Horvat (B63) 2010; 125 Balbona (B38) 1992; 267 Twal (B39) 2001; 114 B31 B32 B33 Chen (B30) 2005; 288 B34 B35 Harris (B65) 2005; 50 B36 B37 B1 B2 B3 B4 B5 Palmans (B64) 2000; 161 B8 B40 B41 B42 B43 B44 B45 Ge (B14) 2015; 5 B46 B47 Dolhnikoff (B7) 2009; 123 B48 B49 Pini (B6) 2014; 9 B50 B51 B52 B53 B10 B54 B11 B55 B12 B56 B13 B57 B58 B15 B59 B16 B17 B18 B19 Argraves (B9) 1990; 111 B60 B61 B62 |
| References_xml | – ident: B25 doi: 10.1371/journal.pone.0091996 – ident: B60 doi: 10.1038/mi.2015.104 – ident: B45 doi: 10.1056/NEJMoa1014350 – ident: B4 doi: 10.1172/JCI60324 – ident: B19 doi: 10.1038/ni.2913 – ident: B23 doi: 10.1128/MCB.21.20.7025-7034.2001 – ident: B42 doi: 10.1002/ijc.2910200102 – volume: 161 start-page: 627 issue: 2 Pt 1 year: 2000 ident: B64 article-title: Prolonged allergen exposure induces structural airway changes in sensitized rats publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.161.2.9902094 contributor: fullname: Palmans – ident: B36 doi: 10.1165/rcmb.2007-0367OC – ident: B37 doi: 10.1038/sj.cr.7290318 – ident: B5 doi: 10.1016/j.clim.2013.12.003 – ident: B8 doi: 10.1002/art.24620 – ident: B52 doi: 10.1038/nrm1130 – ident: B54 doi: 10.1016/0091-6749(91)90189-U – ident: B53 doi: 10.1164/ajrccm.163.5.2101039 – ident: B3 doi: 10.1517/17460441.2014.909805 – ident: B58 doi: 10.1016/0003-9969(76)90043-1 – ident: B59 doi: 10.1164/rccm.200706-958OC – ident: B17 doi: 10.1371/journal.pone.0065544 – ident: B20 doi: 10.1074/jbc.M114.548594 – ident: B1 doi: 10.1016/j.cell.2010.03.015 – ident: B29 doi: 10.1183/09031936.06.00078405 – ident: B50 doi: 10.1046/j.1523-1747.1999.00802.x – volume: 111 start-page: 3155 issue: 6 Pt 2 year: 1990 ident: B9 article-title: Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure publication-title: J Cell Biol doi: 10.1083/jcb.111.6.3155 contributor: fullname: Argraves – ident: B10 doi: 10.1074/jbc.272.36.22600 – ident: B62 doi: 10.1038/nm.3049 – ident: B66 doi: 10.1016/0003-9861(61)90291-0 – ident: B61 doi: 10.1016/j.vaccine.2007.09.034 – ident: B40 doi: 10.1091/mbc.E08-06-0621 – ident: B21 doi: 10.1371/journal.ppat.1004549 – ident: B57 doi: 10.1164/rccm.201501-0188OC – volume: 267 start-page: 20120 issue: 28 year: 1992 ident: B38 article-title: Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)88674-X contributor: fullname: Balbona – volume: 125 issue: 3 year: 2010 ident: B63 article-title: Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2009.10.018 contributor: fullname: Horvat – volume: 288 start-page: L683 issue: 4 year: 2005 ident: B30 article-title: Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00298.2004 contributor: fullname: Chen – ident: B67 doi: 10.1016/j.ab.2012.10.010 – ident: B13 doi: 10.1371/journal.pone.0013360 – ident: B51 doi: 10.1038/nm.1987 – ident: B26 doi: 10.1038/nri2852 – ident: B41 doi: 10.1002/jcb.21224 – ident: B49 doi: 10.1016/j.jaci.2014.05.029 – ident: B43 doi: 10.1074/mcp.M111.014647 – volume: 5 year: 2015 ident: B14 article-title: Fibulin1C peptide induces cell attachment and extracellular matrix deposition in lung fibroblasts publication-title: Sci Rep doi: 10.1038/srep09496 contributor: fullname: Ge – ident: B27 doi: 10.1016/j.immuni.2015.02.011 – ident: B18 doi: 10.1016/j.jaci.2012.11.053 – ident: B31 doi: 10.1111/j.1432-1033.1996.0427h.x – ident: B47 doi: 10.1016/j.jaci.2013.04.012 – ident: B16 doi: 10.1038/nrd3810 – ident: B2 doi: 10.1038/mi.2011.55 – ident: B22 doi: 10.1038/mi.2015.111 – ident: B15 doi: 10.1378/chest.13-2688 – volume: 9 year: 2008 ident: B28 article-title: Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD publication-title: Respir Res doi: 10.1186/1465-9921-9-83 contributor: fullname: Zandvoort – ident: B44 doi: 10.1016/j.matbio.2015.01.016 – ident: B55 doi: 10.1165/rcmb.2010-0157OC – ident: B32 doi: 10.1038/onc.2014.52 – volume: 50 start-page: 78 issue: 1 year: 2005 ident: B65 article-title: Pressure-volume curves of the respiratory system publication-title: Respir Care contributor: fullname: Harris – ident: B46 doi: 10.4049/jimmunol.0901575 – ident: B56 doi: 10.1111/cea.12218 – volume: 9 start-page: 927 year: 2014 ident: B6 article-title: Central airways remodeling in COPD patients publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S52478 contributor: fullname: Pini – volume: 114 start-page: 4587 issue: Pt 24 year: 2001 ident: B39 article-title: Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility publication-title: J Cell Sci doi: 10.1242/jcs.114.24.4587 contributor: fullname: Twal – ident: B11 doi: 10.1016/j.cell.2011.01.014 – volume: 123 issue: 5 year: 2009 ident: B7 article-title: The outer wall of small airways is a major site of remodeling in fatal asthma publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2009.02.032 contributor: fullname: Dolhnikoff – ident: B12 doi: 10.1177/43.4.7534784 – ident: B34 doi: 10.1172/JCI104030 – ident: B24 doi: 10.1016/j.ydbio.2008.04.029 – ident: B48 doi: 10.1152/ajplung.00385.2009 – ident: B35 doi: 10.1513/pats.200905-029DS – ident: B33 doi: 10.4049/jimmunol.177.2.1272 |
| SSID | ssj0001742058 |
| Score | 2.391873 |
| Snippet | Airway and/or lung remodeling, involving exaggerated extracellular matrix (ECM) protein deposition, is a critical feature common to pulmonary diseases... |
| SourceID | pubmedcentral proquest crossref pubmed |
| SourceType | Open Access Repository Aggregation Database Index Database |
| Title | Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27398409 https://search.proquest.com/docview/1826714714 https://pubmed.ncbi.nlm.nih.gov/PMC4936823 |
| Volume | 1 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NS8NAEB1sT15E8at-sYInIW2zX0mOUlqKUFFQ8BZ2t7sasamY9upvd3abFKs3bwnZhPB22PdeZrIDcMVjZTXq9sgKbSMuUhVpqlhk-pnpS5dN0_CT2OROjp_47bN43gLR_AsTivaNLrrl-6xbFq-htvJjZnpNnVjvfjLgGZMpZb0WtJB-f1j08GEFzV5fpHUGE_m592YKVLGVN7vdFOPNd39D1s68t9mkoz8a83ep5A_uGe3CTi0ayc3q5fZgy5b78DAqtC8jj2LyuWoobyuCco74JsPzF7-GFRWZO7II2OKg0PUGqYoUJZ6tU-ykTtJUB_A4Gj4OxlHdICEyXIoFLg4qE1pwQ7niqUIrpV3KpnGsKR5TtArSTacuYybWwqiEO19NmjFHuZO0zw6hXc5LewwEJ0riQpcIZTMumUmRtjVzTlDlFVvSgesGpvxjtQ1GHuxDQnOEN6_hzQO8HbhsgMwxWH0GQpV2vqxyb2aSGPmQd-BoBez6cc2MdCDZgHw9wG-EvXkF4yNsiF3Hw8m_7zyFbRRC0peAxfIM2ovPpT1HsbHQF9CafA0vQoh9A-iL2kI |
| link.rule.ids | 230,314,727,780,784,885,27924,27925,53791,53793 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PT9swFH5i7LBd0NDYFtjAkzghpW38K_FxQlSFUQRSkbhFtmuPIJpWpPz_PLtJRceNW6I4UfT5ye_78r74ARzzTDuDvD11wriUi0KnhmqW2oGyA-nVtIg_iY2v5OiWX9yJuy0Q3b8w0bRvTdWrH2e9urqP3srFzPY7n1j_enzKFZMFZf0P8FGwXGWvRHr8tIJybyCKtoaJGbr_YCvksU2Qu70CIy70f8O8rYK62UxIb1jm_2bJV9ln-AV2WtpI_qxebxe2XP0VboaVCUbyNCNPq5byriFI6EhoMzz_F1axqiFzT5YRXRwU-95gsiJVjWfrIjtpyzTNHkyGZ5PTUdq2SEgtl2KJy4NWwghuKde80CimjC_YNMsMxWOKYkH66dQrZjMjrM65D35SxTzlXtIB-wbb9bx2P4DgVElc6nKhneKS2QITt2HeC6oDZ8sTOOlgKherjTDKKCByWiK8ZQtvGeFN4HcHZInhGmoQunbz56YMcibPMCPyBL6vgF0_rpuRBPINyNcDwlbYm1cwQuKW2G1E7L_7ziP4NJqML8vL86u_B_AZaZEMhrBM_oTt5dOz-4XUY2kOY6C9AF9I3GY |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bS8MwFA5eQHwRxdu8RvBJ6Lrm1vZR1DGvTJjgW0nSRCuuG-v2_z3JurHpm28tTUv5csj5vp6vOQhdskgaBbw9MFyZgPFEBopIGuhWqlvCpnnifxJ7fhGdN_bwzt8XWn15075WRbP87jfL4tN7K4d9Hc58YmH3-YalVCSEhsPchqtonVMIsgWh7j-vgORr8aSuY0KWDr90AVy2cpK3mUDUuR5wkLtTp3CWk9IfpvnbMLmQgdrbaKumjvh6-oo7aMWUu-i1XShnJg8iPJq2lTcVBlKHXavhwYdbyYoKDywee4RhkO99AwkLFyWczQvtuC7VVHuo177r3XSCuk1CoJngY1giZMoVZ5owyRIJgkrZhOZRpAgcExAMwua5TamOFNcyZtZ5SlNqCbOCtOg-WisHpTlEGKZLwHIXc2lSJqhOIHkrai0n0vG2uIGuZjBlw-lmGJkXETHJAN6shjfz8DbQxQzIDELW1SFkaQaTKnOSJo4gK7IGOpgCO3_cbEYaKF6CfD7AbYe9fAWixG-LXUfF0b_vPEcb3dt29nT_8niMNoEZCecJi8QJWhuPJuYU2MdYnfk4-wGE0N15 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fibulin-1+regulates+the+pathogenesis+of+tissue+remodeling+in+respiratory+diseases&rft.jtitle=JCI+insight&rft.au=Liu%2C+Gang&rft.au=Cooley%2C+Marion+A.&rft.au=Jarnicki%2C+Andrew+G.&rft.au=Hsu%2C+Alan+C-Y.&rft.date=2016-06-16&rft.pub=American+Society+for+Clinical+Investigation&rft.eissn=2379-3708&rft.volume=1&rft.issue=9&rft_id=info:doi/10.1172%2Fjci.insight.86380&rft_id=info%3Apmid%2F27398409&rft.externalDBID=PMC4936823 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2379-3708&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2379-3708&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2379-3708&client=summon |