Categorization of the Ocular Microbiome in Japanese Stevens–Johnson Syndrome Patients With Severe Ocular Complications

• Published in: Frontiers in cellular and infection microbiology Vol. 11; p. 741654
• Main Authors: Ueta, Mayumi, Hosomi, Koji, Park, Jonguk, Mizuguchi, Kenji, Sotozono, Chie, Kinoshita, Shigeru, Kunisawa, Jun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 19.11.2021
• Subjects: Cellular and Infection Microbiology; Corynebacterium; Cross-Sectional Studies; Humans; Japan; Microbiota; mucosal immunity; Neisseriaceae; ocular microbiome; RNA, Ribosomal, 16S - genetics; Staphylococcus; Stevens-Johnson Syndrome; Stevens–Johnson syndrome (SJS); Japan; ocular microbiome; Corynebacterium; inflammation; toxic epidermal necrolysis (TEN); Neisseriaceae; Stevens–Johnson syndrome (SJS); Staphylococcus; mucosal immunity
• ISSN: 2235-2988; 2235-2988
• DOI: 10.3389/fcimb.2021.741654

The commensal microbiota is involved in a variety of diseases. Our group has noticed that patients with Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) often present with persistent inflammation of the ocular surface, even in the chronic stage, and that this inflammation is exacerbat...