Extracellular ATP regulates FoxO family of transcription factors and cell cycle progression through PI3K/Akt in MCF-7 cells

• Published in: Biochimica et biophysica acta Vol. 1830; no. 10; pp. 4456 - 4469
• Main Authors: Scodelaro Bilbao, Paola, Boland, Ricardo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2013
• Subjects: adenosine triphosphate; Adenosine Triphosphate - metabolism; Blotting, Western; breast neoplasms; Cell Cycle; cyclins; cytoplasm; Extracellular ATP; flow cytometry; Forkhead Transcription Factors - metabolism; FoxO transcription factors; fractionation; genes; Humans; immunocytochemistry; interphase; MCF-7 Cells; neoplasm cells; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-Kinases - metabolism; phosphorylation; PI3K/Akt; proteasome endopeptidase complex; protein-serine-threonine kinases; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; purinergic receptors; RNA, Small Interfering - genetics; signal transduction; small interfering RNA; threonine; transcription factors; Western blotting; MCF-7 cells; Extracellular ATP; FoxO transcription factors; Cell cycle; PI3K/Akt

Forkhead Box-O (FoxO) transcription factors regulate the expression of many genes involved in suppression. Released nucleotides can regulate intracellular signaling pathways through membrane-bound purinergic receptors, to promote or prevent malignant cell transformation. We studied the role of extra...