The New Antibacterial Properties of the Plants: Quo vadis Studies of Anti-virulence Phytochemicals?

The recent increase in bacterial resistance to antibiotics has motivated the resurgence of the study of natural antimicrobial products. For centuries, plants have been recognized for their bactericidal properties. However, in the last two decades, it has been reported that several plant derived meta...

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Published inFrontiers in microbiology Vol. 12; p. 667126
Main Authors Díaz-Nuñez, José Luis, García-Contreras, Rodolfo, Castillo-Juárez, Israel
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 07.05.2021
Subjects
adjuvants
anti-virulence
antimicrobial phytochemicals
Microbiology
quorum sensing
virulence factors
quorum sensing
anti-virulence
antimicrobial phytochemicals
virulence factors
adjuvants
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Summary:The recent increase in bacterial resistance to antibiotics has motivated the resurgence of the study of natural antimicrobial products. For centuries, plants have been recognized for their bactericidal properties. However, in the last two decades, it has been reported that several plant derived metabolites at growth subinhibitory concentrations also tend to have anti-virulence properties, since they reduce the expression of factors that cause damage and the establishment of pathogenic bacteria. In this area of study, plants have been positioned as one of the main natural sources of anti-virulence molecules, but only a small portion of the plant species that exist have been investigated. Also, anti-virulence studies have been primarily focused on analyzing the ability of extracts and compounds to inhibit quorum sensing and biofilms formation . This mini-review discusses the current panorama, the trends in the study of anti-virulence phytochemicals, as well as their potential for the development of antibacterial therapies.
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Edited by: Ponmurugan Karuppiah, King Saud University, Saudi Arabia
Reviewed by: Maria José Saavedra, Universidade de Trás os Montes e Alto Douro, Portugal; Faizan Abul Qais, Aligarh Muslim University, India; Fazlurrahman Khan, Sharda University, India
This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2021.667126