Liraglutide Attenuates Hepatic Ischemia–Reperfusion Injury by Modulating Macrophage Polarization

• Published in: Frontiers in immunology Vol. 13; p. 869050
• Main Authors: Li, Shang-Lin, Wang, Zhi-Min, Xu, Cong, Che, Fu-Heng, Hu, Xiao-Fan, Cao, Rui, Xie, Ya-Nan, Qiu, Yang, Shi, Hui-Bo, Liu, Bin, Dai, Chen, Yang, Jun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.04.2022
• Subjects: acute liver injury; Animals; Diabetes Mellitus, Type 2 - drug therapy; glucagon-like peptide-1 receptor; Immunology; ischemia-reperfusion; Lipopolysaccharides - pharmacology; liraglutide; Liraglutide - pharmacology; Liraglutide - therapeutic use; Liver - metabolism; macrophage polarization; Macrophages - metabolism; Mice; Mice, Inbred C57BL; Reperfusion Injury - metabolism; liraglutide; macrophage polarization; ischemia-reperfusion; glucagon-like peptide-1 receptor; acute liver injury

Ischemia-reperfusion injury (IRI) is a common complication associated with liver surgery, and macrophages play an important role in hepatic IRI. Liraglutide, a glucagon-like peptide-1 (GLP-1) analog primarily used to treat type 2 diabetes and obesity, regulates intracellular calcium homeostasis and...