Antagonistic effects of selenium on lead-induced autophagy by influencing mitochondrial dynamics in the spleen of chickens

• Published in: Oncotarget Vol. 8; no. 20; pp. 33725 - 33735
• Main Authors: Han, Yujing, Li, Chunqiu, Su, Mingjun, Wang, Zhihui, Jiang, Ning, Sun, Dongbo
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 16.05.2017
• Subjects: Animals; Antioxidants - pharmacology; Apoptosis - drug effects; Apoptosis - genetics; Autophagy - drug effects; Autophagy - genetics; Biomarkers; Chickens; Cytokines - genetics; Cytokines - metabolism; Lead - pharmacology; Mitochondria - drug effects; Mitochondria - genetics; Mitochondria - metabolism; Mitochondria - ultrastructure; Mitochondrial Dynamics - drug effects; Oxidative Stress - drug effects; Research Paper; Selenium - pharmacology; Spleen - drug effects; Spleen - metabolism; autophagy; chickens spleen; selenium; lead; mitochondrial dynamics

Lead (Pb) may damage the immune function in human and animal. Selenium (Se) has antagonistic effects on Pb. In our study, brown layer chickens were randomly allocated to control group, Se group (1 mg/kg Se), Se+Pb group (1 mg/kg Se and 350 mg/kg Pb), and Pb group (350 mg/kg Pb). The chickens were sa...