Protein Lactylation Critically Regulates Energy Metabolism in the Protozoan Parasite Trypanosoma brucei

• Published in: Frontiers in cell and developmental biology Vol. 9; p. 719720
• Main Authors: Zhang, Naiwen, Jiang, Ning, Yu, Liying, Guan, Tiandong, Sang, Xiaoyu, Feng, Ying, Chen, Ran, Chen, Qijun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.10.2021
• Subjects: Cell and Developmental Biology; lactate; lactylation; metabolism; post-translational modification; Trypanosoma brucei; metabolism; post-translational modification; Trypanosoma brucei; lactate; lactylation

Lysine lactylation has been recognized as a novel post-translational modification occurring on histones. However, lactylation in non-histone proteins, especially in proteins of early branching organisms, is not well understood. Energy metabolism and the histone repertoire in the early diverging prot...