Elevated X-Box Binding Protein1 Splicing and Interleukin-17A Expression Are Associated With Active Generalized Vitiligo in Gujarat Population

• Published in: Frontiers in immunology Vol. 12; p. 801724
• Main Authors: Jadeja, Shahnawaz D., Vaishnav, Jayvadan, Bharti, Ankit H., Begum, Rasheedunnisa
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 03.01.2022
• Subjects: autoimmunity; cytokines; endoplasmic reticulum stress (ER stress); Endoplasmic Reticulum Stress - genetics; genetic polymorphisms and disease association; Genetic Predisposition to Disease; Genotype; Humans; Immunology; India; interleukin; Interleukin-17 - genetics; Oxidative Stress - genetics; Polymorphism, Single Nucleotide; RNA Splicing; vitiligo; Vitiligo - genetics; X-Box Binding Protein 1 - genetics; India; vitiligo; endoplasmic reticulum stress (ER stress); cytokines; genetic polymorphisms and disease association; autoimmunity; interleukin

Vitiligo is an autoimmune skin disorder defined by the destruction of functional epidermal melanocytes. It is a multifactorial and polygenic disorder caused due to oxidative stress, endoplasmic reticulum (ER) stress, and autoimmunity, among other factors. In the present study, we aimed to investigat...