Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases

• Published in: Frontiers in immunology Vol. 11; p. 617089
• Main Authors: Vojdani, Aristo, Vojdani, Elroy, Kharrazian, Datis
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 19.01.2021
• Subjects: Antibodies, Monoclonal - immunology; Antibodies, Viral - immunology; autoimmunity; Autoimmunity - immunology; Coronavirus Nucleocapsid Proteins - immunology; COVID-19; COVID-19 - immunology; Cross Reactions - immunology; cross-reactivity; Humans; Immunology; molecular mimicry; Molecular Mimicry - immunology; Phosphoproteins - immunology; SARS-CoV-2; SARS-CoV-2 - immunology; Spike Glycoprotein, Coronavirus - immunology; COVID-19; molecular mimicry; SARS-CoV-2; cross-reactivity; autoimmunity

We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein...