Intranasal naloxone rapidly occupies brain mu-opioid receptors in human subjects - Johansson, Jarkko; Hirvonen, Jussi; Lovró, Zsófia; Ekblad, Laura; Kaasinen, Valtteri; Rajasilta, Olli; Helin, Semi; Tuisku, Jouni; Sirén, Saija; Pennanen, Mirka; Agrawal, Arvind; Crystal, Roger; et al. (Neuropsychopharmacology (New York, N.Y.), 2019)
Keywords: Administration, Intranasal; Adult; Agonists; Analgesics, Opioid; Brain - diagnostic imaging; Brain - metabolism; Double-Blind Method; Drug overdose; Fentanyl - analogs & derivatives; Healthy Volunteers; Human subjects; Humans; Male; Naloxone; Naloxone - pharmacokinetics; Narcotic Antagonists - pharmacokinetics; Narcotics; Opioid receptors (type mu); Overdose; Positron emission tomography; Receptors, Opioid, mu - metabolism; Young Adult