Structural Characterization, Antimicrobial, Antibiofilm, Antioxidant, Anticancer and Acute Toxicity Properties of N-(2-hydroxyphenyl)-2-phenazinamine From Nocardiopsis exhalans (KP149558)
The present study aimed to isolate and identify potential drugs from marine actinomycete Nocardiopsis exhalans and screen them for biomedical applications. The cell-free culture of N. exhalans was extracted with ethyl acetate and the solvent extract showed six fractions in thin-layer chromatography....
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| Published in | Frontiers in cellular and infection microbiology Vol. 12; p. 794338 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
19.05.2022
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present study aimed to isolate and identify potential drugs from marine actinomycete
Nocardiopsis exhalans
and screen them for biomedical applications. The cell-free culture of
N.
exhalans was extracted with ethyl acetate and the solvent extract showed six fractions in thin-layer chromatography. The fractions were subjected to column chromatography for purification and evaluated for activity against human clinical pathogens. Fraction 4 showed significant activity and was identified as N-(2-hydroxyphenyl)-2-phenazinamine (NHP) using spectral analyses. Further, NHP showed excellent biofilm inhibitory activity against human clinical pathogens
Escherichia coli
,
Pseudomonas aeruginosa
, and
Staphylococcus aureus
. The
in vitro
antioxidant activity confirmed that NHP is scavenging the oxidative stress-enhancing molecules. The anti-proliferative activity of NHP against human breast cancer cells showed significant activity at 300 µg/ml and less cytotoxic activity against normal cells. Additionally, the toxicity assessment against zebrafish revealed that NHP does not cause any toxicity in the important organs. The results highlight
N. exhalans
as a promising candidate for the development of antibiotics with potential therapeutic applications. |
|---|---|
| AbstractList | The present study aimed to isolate and identify potential drugs from marine actinomycete Nocardiopsis exhalans and screen them for biomedical applications. The cell-free culture of N. exhalans was extracted with ethyl acetate and the solvent extract showed six fractions in thin-layer chromatography. The fractions were subjected to column chromatography for purification and evaluated for activity against human clinical pathogens. Fraction 4 showed significant activity and was identified as N-(2-hydroxyphenyl)-2-phenazinamine (NHP) using spectral analyses. Further, NHP showed excellent biofilm inhibitory activity against human clinical pathogens Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antioxidant activity confirmed that NHP is scavenging the oxidative stress-enhancing molecules. The anti-proliferative activity of NHP against human breast cancer cells showed significant activity at 300 µg/ml and less cytotoxic activity against normal cells. Additionally, the toxicity assessment against zebrafish revealed that NHP does not cause any toxicity in the important organs. The results highlight N. exhalans as a promising candidate for the development of antibiotics with potential therapeutic applications. The present study aimed to isolate and identify potential drugs from marine actinomycete Nocardiopsis exhalans and screen them for biomedical applications. The cell-free culture of N. exhalans was extracted with ethyl acetate and the solvent extract showed six fractions in thin-layer chromatography. The fractions were subjected to column chromatography for purification and evaluated for activity against human clinical pathogens. Fraction 4 showed significant activity and was identified as N-(2-hydroxyphenyl)-2-phenazinamine (NHP) using spectral analyses. Further, NHP showed excellent biofilm inhibitory activity against human clinical pathogens Escherichia coli , Pseudomonas aeruginosa , and Staphylococcus aureus . The in vitro antioxidant activity confirmed that NHP is scavenging the oxidative stress-enhancing molecules. The anti-proliferative activity of NHP against human breast cancer cells showed significant activity at 300 µg/ml and less cytotoxic activity against normal cells. Additionally, the toxicity assessment against zebrafish revealed that NHP does not cause any toxicity in the important organs. The results highlight N. exhalans as a promising candidate for the development of antibiotics with potential therapeutic applications. The present study aimed to isolate and identify potential drugs from marine actinomycete and screen them for biomedical applications. The cell-free culture of exhalans was extracted with ethyl acetate and the solvent extract showed six fractions in thin-layer chromatography. The fractions were subjected to column chromatography for purification and evaluated for activity against human clinical pathogens. Fraction 4 showed significant activity and was identified as N-(2-hydroxyphenyl)-2-phenazinamine (NHP) using spectral analyses. Further, NHP showed excellent biofilm inhibitory activity against human clinical pathogens , , and . The antioxidant activity confirmed that NHP is scavenging the oxidative stress-enhancing molecules. The anti-proliferative activity of NHP against human breast cancer cells showed significant activity at 300 µg/ml and less cytotoxic activity against normal cells. Additionally, the toxicity assessment against zebrafish revealed that NHP does not cause any toxicity in the important organs. The results highlight as a promising candidate for the development of antibiotics with potential therapeutic applications. The present study aimed to isolate and identify potential drugs from marine actinomycete Nocardiopsis exhalans and screen them for biomedical applications. The cell-free culture of N. exhalans was extracted with ethyl acetate and the solvent extract showed six fractions in thin-layer chromatography. The fractions were subjected to column chromatography for purification and evaluated for activity against human clinical pathogens. Fraction 4 showed significant activity and was identified as N-(2-hydroxyphenyl)-2-phenazinamine (NHP) using spectral analyses. Further, NHP showed excellent biofilm inhibitory activity against human clinical pathogens Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antioxidant activity confirmed that NHP is scavenging the oxidative stress-enhancing molecules. The anti-proliferative activity of NHP against human breast cancer cells showed significant activity at 300 µg/ml and less cytotoxic activity against normal cells. Additionally, the toxicity assessment against zebrafish revealed that NHP does not cause any toxicity in the important organs. The results highlight N. exhalans as a promising candidate for the development of antibiotics with potential therapeutic applications.The present study aimed to isolate and identify potential drugs from marine actinomycete Nocardiopsis exhalans and screen them for biomedical applications. The cell-free culture of N. exhalans was extracted with ethyl acetate and the solvent extract showed six fractions in thin-layer chromatography. The fractions were subjected to column chromatography for purification and evaluated for activity against human clinical pathogens. Fraction 4 showed significant activity and was identified as N-(2-hydroxyphenyl)-2-phenazinamine (NHP) using spectral analyses. Further, NHP showed excellent biofilm inhibitory activity against human clinical pathogens Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antioxidant activity confirmed that NHP is scavenging the oxidative stress-enhancing molecules. The anti-proliferative activity of NHP against human breast cancer cells showed significant activity at 300 µg/ml and less cytotoxic activity against normal cells. Additionally, the toxicity assessment against zebrafish revealed that NHP does not cause any toxicity in the important organs. The results highlight N. exhalans as a promising candidate for the development of antibiotics with potential therapeutic applications. |
| Author | Rajaram, Rajendran Gulyás, Balázs Archunan, Govindaraju Ramalingam, Vaikundamoorthy Padmanabhan, Parasuraman |
| AuthorAffiliation | 1 Centre for Natural Products and Traditional Knowledge, Indian Institute of Chemical Technology , Hyderabad , India 2 DNA Barcoding and Marine Genomics Lab, Department of Marine Science, Bharathidasan University , Tiruchirappalli , India 7 Imaging Probe Development Platform (IPDP), Nanyang Technological University , Singapore , Singapore 4 Dean of Research, Marudupandiyar College , Thanjavur , India 3 Department of Animal Science, Bharathidasan University Tiruchirappalli , Tamil Nadu , India 5 Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore , Singapore 6 Cognitive Neuroimaging Centre, Nanyang Technological University , Nanyang Technological University, Singapore , Singapore |
| AuthorAffiliation_xml | – name: 3 Department of Animal Science, Bharathidasan University Tiruchirappalli , Tamil Nadu , India – name: 6 Cognitive Neuroimaging Centre, Nanyang Technological University , Nanyang Technological University, Singapore , Singapore – name: 1 Centre for Natural Products and Traditional Knowledge, Indian Institute of Chemical Technology , Hyderabad , India – name: 7 Imaging Probe Development Platform (IPDP), Nanyang Technological University , Singapore , Singapore – name: 5 Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore , Singapore – name: 4 Dean of Research, Marudupandiyar College , Thanjavur , India – name: 2 DNA Barcoding and Marine Genomics Lab, Department of Marine Science, Bharathidasan University , Tiruchirappalli , India |
| Author_xml | – sequence: 1 givenname: Vaikundamoorthy surname: Ramalingam fullname: Ramalingam, Vaikundamoorthy – sequence: 2 givenname: Rajendran surname: Rajaram fullname: Rajaram, Rajendran – sequence: 3 givenname: Govindaraju surname: Archunan fullname: Archunan, Govindaraju – sequence: 4 givenname: Parasuraman surname: Padmanabhan fullname: Padmanabhan, Parasuraman – sequence: 5 givenname: Balázs surname: Gulyás fullname: Gulyás, Balázs |
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| Cites_doi | 10.1007/s40009-013-0193-4 10.3389/fmicb.2017.02420 10.3390/md17050249 10.3389/fmicb.2017.00760 10.1007/s13205-018-1222-2 10.1016/j.jallcom.2020.155118 10.1271/bbb.90636 10.1016/j.ejmech.2013.07.017 10.3390/microorganisms9020455 10.1021/acs.chemrev.5b00407 10.1039/c9ra03579f 10.1038/s41586-020-2238-4 10.1016/j.micres.2012.02.008 10.1111/j.1574-6968.2010.02149.x 10.1007/s12088-011-0097-2 10.3390/microorganisms6030072 10.3389/fmicb.2016.01295 10.1038/s41467-019-08438-0 10.1007/s00253-015-7156-2 10.3389/fmicb.2019.01404 10.1016/j.bioorg.2018.02.014 10.1007/s00284-009-9564-y 10.1016/j.procbio.2020.09.032 10.1007/s10482-014-0233-1 10.3389/fmicb.2019.01018 10.1016/j.ejar.2015.03.006 10.7554/eLife.64139 10.1039/c5ra22558b 10.3390/pr8040470 10.1016/s2666-5247(21)00173-7 10.2147/idr.S173867 10.3389/fmicb.2017.00947 10.1002/etc.5620220431 10.1016/j.micres.2011.12.003 10.1016/j.cbi.2018.03.016 10.1007/s11274-009-9969-6 10.1155/2021/5586165 10.1080/08927014.2010.511200 10.1039/c4ra15335a 10.1016/j.micpath.2019.05.021 10.1039/c9dt04576g 10.1016/j.colsurfa.2020.125469 10.1186/s12866-015-0495-4 10.1186/s12866-014-0278-3 |
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| Copyright | Copyright © 2022 Ramalingam, Rajaram, Archunan, Padmanabhan and Gulyás. Copyright © 2022 Ramalingam, Rajaram, Archunan, Padmanabhan and Gulyás 2022 Ramalingam, Rajaram, Archunan, Padmanabhan and Gulyás |
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| Keywords | antimicrobial antioxidant Nocardiopsis exhalans antibiofilm acute toxicity anticancer |
| Language | English |
| License | Copyright © 2022 Ramalingam, Rajaram, Archunan, Padmanabhan and Gulyás. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Snippet | The present study aimed to isolate and identify potential drugs from marine actinomycete
Nocardiopsis exhalans
and screen them for biomedical applications. The... The present study aimed to isolate and identify potential drugs from marine actinomycete and screen them for biomedical applications. The cell-free culture of... The present study aimed to isolate and identify potential drugs from marine actinomycete Nocardiopsis exhalans and screen them for biomedical applications. The... |
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| SubjectTerms | acute toxicity Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Infective Agents - chemistry Anti-Infective Agents - toxicity antibiofilm anticancer antimicrobial antioxidant Antioxidants - pharmacology Biofilms Cellular and Infection Microbiology Escherichia coli Microbial Sensitivity Tests Nocardia Nocardiopsis Nocardiopsis exhalans Zebrafish |
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| Title | Structural Characterization, Antimicrobial, Antibiofilm, Antioxidant, Anticancer and Acute Toxicity Properties of N-(2-hydroxyphenyl)-2-phenazinamine From Nocardiopsis exhalans (KP149558) |
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