Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions
Cyclophilins (Cyps) are a group of peptidyl-prolyl isomerases that play crucial roles in regulatory mechanisms of cellular physiology and pathology in several inflammatory conditions. Their receptor, CD147, also participates in the development and progression of the inflammatory response. Neverthele...
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Published in | Frontiers in immunology Vol. 12; p. 609196 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
30.03.2021
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Subjects | |
Online Access | Get full text |
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Summary: | Cyclophilins (Cyps) are a group of peptidyl-prolyl
isomerases that play crucial roles in regulatory mechanisms of cellular physiology and pathology in several inflammatory conditions. Their receptor, CD147, also participates in the development and progression of the inflammatory response. Nevertheless, the main function of Cyps and their receptor are yet to be deciphered. The release of CypA and the expression of the CD147 receptor in activated T lymphocytes were already described, however, no data are available about other Cyps in these cells. Therefore, in the present work intra and extracellular CypA, B and C levels were measured followed by induced inflammatory conditions. After activation of T lymphocytes by incubation with concanavalin A, both intra and extracellular Cyps levels and the CD147 membrane receptor expression were increased leading to cell migration towards circulating CypA and CypB as chemoattractants. When CypA was modulated by natural and synthetic compounds, the inflammatory cascade was avoided including T cell migration. Our results strengthen the relationship between CypA, B, and C, their receptor, and the inflammatory process in human T lymphocytes, associating CypC with these cells for the first time. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Sinéad Marian Smith, Trinity College Dublin, Ireland; Jon C.D. Houtman, The University of Iowa, United States; Vyacheslav Yurchenko, University of Ostrava, Czechia This article was submitted to T Cell Biology, a section of the journal Frontiers in Immunology Edited by: Michael Bukrinsky, George Washington University, United States |
ISSN: | 1664-3224 1664-3224 |
DOI: | 10.3389/fimmu.2021.609196 |