Alk5 inhibition increases delivery of macromolecular and protein-bound contrast agents to tumors

Limited transendothelial permeability across tumor microvessels represents a significant bottleneck in the development of tumor-specific diagnostic agents and theranostic drugs. Here, we show an approach to increase transendothelial permeability of macromolecular and nanoparticle-based contrast agen...

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Bibliographic Details
Published inJCI insight Vol. 1; no. 6
Main Authors Daldrup-Link, Heike E., Mohanty, Suchismita, Ansari, Celina, Lenkov, Olga, Shaw, Aubie, Ito, Ken, Hong, Su Hyun, Hoffmann, Matthias, Pisani, Laura, Boudreau, Nancy, Gambhir, Sanjiv Sam, Coussens, Lisa M.
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 05.05.2016
Online AccessGet full text
ISSN2379-3708
2379-3708
DOI10.1172/jci.insight.85608

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