Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry - Draczkowski, Piotr; Tomaszuk, Anna; Halczuk, Pawel; Strzemski, Maciej; Matosiuk, Dariusz; Jozwiak, Krzysztof (Biochimica et biophysica acta, 2016)
Keywords: acetylcholine; Acetylcholine - chemistry; Acetylcholinesterase; Acetylcholinesterase - chemistry; Alzheimer disease; Ambenonium Chloride - chemistry; Animals; calorimetry; Calorimetry - methods; Cholinesterase Inhibitors - chemistry; Edrophonium - chemistry; Electrophorus - metabolism; Electrophorus electricus; enthalpy; Enzyme activity assay; Fish Proteins - antagonists & inhibitors; Fish Proteins - chemistry; Galantamine - chemistry; Indans - chemistry; Inhibitor; inhibitory concentration 50; Interactions; Isothermal titration calorimetry; ITC; Kinetics; memory; nerve tissue; neurons; Piperidines - chemistry; synapse; Tacrine - chemistry; Thermodynamics; titration; ITC; Inhibitor; Isothermal titration calorimetry; Interactions; Acetylcholinesterase; Enzyme activity assay