Probiotic Interventions Alleviate Food Allergy Symptoms Correlated With Cesarean Section: A Murine Model

• Published in: Frontiers in immunology Vol. 12; p. 741371
• Main Authors: Jin, Bi-Ying, Li, Zhen, Xia, Ya-Nan, Li, Li-Xiang, Zhao, Zi-Xiao, Li, Xiao-Yu, Li, Yan, Li, Bing, Zhou, Ru-Chen, Fu, Shi-Chen, Li, Shi-Yang, Li, Yan-Qing
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.09.2021
• Subjects: Allergens - immunology; Animals; Bifidobacterium - genetics; Bifidobacterium - immunology; Cells, Cultured; cesarean section; Cesarean Section - statistics & numerical data; Disease Models, Animal; Dysbiosis - prevention & control; Female; food allergy; Food Hypersensitivity - epidemiology; Food Hypersensitivity - prevention & control; Gastrointestinal Microbiome - immunology; Humans; Immunoglobulin E - blood; Immunology; intestinal microbiota; Lactobacillus - genetics; Lactobacillus - immunology; Male; Ovalbumin - immunology; Pregnancy; probiotics; Probiotics - administration & dosage; Rats; Rats, Sprague-Dawley; RNA, Ribosomal, 16S - genetics; Th2 Cells - immunology; Th2 response; tight junction; Tight Junctions - metabolism; intestinal microbiota; cesarean section; Th2 response; food allergy; tight junction; probiotics

Delivery by cesarean section (CS) is linked to an increased incidence of food allergies in children and affects early gut microbiota colonization. Furthermore, emerging evidence has connected disordered intestinal microbiota to food allergies. Here, we investigated the impact of CS on a rat model fo...