Probiotic Interventions Alleviate Food Allergy Symptoms Correlated With Cesarean Section: A Murine Model

Delivery by cesarean section (CS) is linked to an increased incidence of food allergies in children and affects early gut microbiota colonization. Furthermore, emerging evidence has connected disordered intestinal microbiota to food allergies. Here, we investigated the impact of CS on a rat model fo...

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Published inFrontiers in immunology Vol. 12; p. 741371
Main Authors Jin, Bi-Ying, Li, Zhen, Xia, Ya-Nan, Li, Li-Xiang, Zhao, Zi-Xiao, Li, Xiao-Yu, Li, Yan, Li, Bing, Zhou, Ru-Chen, Fu, Shi-Chen, Li, Shi-Yang, Li, Yan-Qing
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 28.09.2021
Subjects
Allergens - immunology
Animals
Bifidobacterium - genetics
Bifidobacterium - immunology
Cells, Cultured
cesarean section
Cesarean Section - statistics & numerical data
Disease Models, Animal
Dysbiosis - prevention & control
Female
food allergy
Food Hypersensitivity - epidemiology
Food Hypersensitivity - prevention & control
Gastrointestinal Microbiome - immunology
Humans
Immunoglobulin E - blood
Immunology
intestinal microbiota
Lactobacillus - genetics
Lactobacillus - immunology
Male
Ovalbumin - immunology
Pregnancy
probiotics
Probiotics - administration & dosage
Rats
Rats, Sprague-Dawley
RNA, Ribosomal, 16S - genetics
Th2 Cells - immunology
Th2 response
tight junction
Tight Junctions - metabolism
intestinal microbiota
cesarean section
Th2 response
food allergy
tight junction
probiotics
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Abstract Delivery by cesarean section (CS) is linked to an increased incidence of food allergies in children and affects early gut microbiota colonization. Furthermore, emerging evidence has connected disordered intestinal microbiota to food allergies. Here, we investigated the impact of CS on a rat model for food allergy to ovalbumin (OVA). Rats delivered by CS were found to be more responsive to OVA sensitization than vaginally born ones, displaying a greater reduction in rectal temperature upon challenge, worse diarrhea, and higher levels of OVA-specific antibodies and histamine. 16S rRNA sequencing of feces revealed reduced levels of Lactobacillus and Bifidobacterium in the CS rats. Preventative supplementation with a probiotic combination containing Lactobacillus and Bifidobacterium could protect CS rats against an allergic response to OVA, indicating that the microbiota dysbiosis contributes to CS-related response. Additionally, probiotic intervention early in life might help to rebuild aberrant Th2 responses and tight junction proteins, both of which have been linked to CS-related high allergic reactions. Taken together, this study shows that disordered intestinal microbiota plays an essential role in the pathogenesis of food allergy mediated by CS. More importantly, interventions that modulate the microbiota composition in early life are therapeutically relevant for CS-related food allergies.
AbstractList Delivery by cesarean section (CS) is linked to an increased incidence of food allergies in children and affects early gut microbiota colonization. Furthermore, emerging evidence has connected disordered intestinal microbiota to food allergies. Here, we investigated the impact of CS on a rat model for food allergy to ovalbumin (OVA). Rats delivered by CS were found to be more responsive to OVA sensitization than vaginally born ones, displaying a greater reduction in rectal temperature upon challenge, worse diarrhea, and higher levels of OVA-specific antibodies and histamine. 16S rRNA sequencing of feces revealed reduced levels of Lactobacillus and Bifidobacterium in the CS rats. Preventative supplementation with a probiotic combination containing Lactobacillus and Bifidobacterium could protect CS rats against an allergic response to OVA, indicating that the microbiota dysbiosis contributes to CS-related response. Additionally, probiotic intervention early in life might help to rebuild aberrant Th2 responses and tight junction proteins, both of which have been linked to CS-related high allergic reactions. Taken together, this study shows that disordered intestinal microbiota plays an essential role in the pathogenesis of food allergy mediated by CS. More importantly, interventions that modulate the microbiota composition in early life are therapeutically relevant for CS-related food allergies.
Delivery by cesarean section (CS) is linked to an increased incidence of food allergies in children and affects early gut microbiota colonization. Furthermore, emerging evidence has connected disordered intestinal microbiota to food allergies. Here, we investigated the impact of CS on a rat model for food allergy to ovalbumin (OVA). Rats delivered by CS were found to be more responsive to OVA sensitization than vaginally born ones, displaying a greater reduction in rectal temperature upon challenge, worse diarrhea, and higher levels of OVA-specific antibodies and histamine. 16S rRNA sequencing of feces revealed reduced levels of Lactobacillus and Bifidobacterium in the CS rats. Preventative supplementation with a probiotic combination containing Lactobacillus and Bifidobacterium could protect CS rats against an allergic response to OVA, indicating that the microbiota dysbiosis contributes to CS-related response. Additionally, probiotic intervention early in life might help to rebuild aberrant Th2 responses and tight junction proteins, both of which have been linked to CS-related high allergic reactions. Taken together, this study shows that disordered intestinal microbiota plays an essential role in the pathogenesis of food allergy mediated by CS. More importantly, interventions that modulate the microbiota composition in early life are therapeutically relevant for CS-related food allergies.Delivery by cesarean section (CS) is linked to an increased incidence of food allergies in children and affects early gut microbiota colonization. Furthermore, emerging evidence has connected disordered intestinal microbiota to food allergies. Here, we investigated the impact of CS on a rat model for food allergy to ovalbumin (OVA). Rats delivered by CS were found to be more responsive to OVA sensitization than vaginally born ones, displaying a greater reduction in rectal temperature upon challenge, worse diarrhea, and higher levels of OVA-specific antibodies and histamine. 16S rRNA sequencing of feces revealed reduced levels of Lactobacillus and Bifidobacterium in the CS rats. Preventative supplementation with a probiotic combination containing Lactobacillus and Bifidobacterium could protect CS rats against an allergic response to OVA, indicating that the microbiota dysbiosis contributes to CS-related response. Additionally, probiotic intervention early in life might help to rebuild aberrant Th2 responses and tight junction proteins, both of which have been linked to CS-related high allergic reactions. Taken together, this study shows that disordered intestinal microbiota plays an essential role in the pathogenesis of food allergy mediated by CS. More importantly, interventions that modulate the microbiota composition in early life are therapeutically relevant for CS-related food allergies.
Delivery by cesarean section (CS) is linked to an increased incidence of food allergies in children and affects early gut microbiota colonization. Furthermore, emerging evidence has connected disordered intestinal microbiota to food allergies. Here, we investigated the impact of CS on a rat model for food allergy to ovalbumin (OVA). Rats delivered by CS were found to be more responsive to OVA sensitization than vaginally born ones, displaying a greater reduction in rectal temperature upon challenge, worse diarrhea, and higher levels of OVA-specific antibodies and histamine. 16S rRNA sequencing of feces revealed reduced levels of and in the CS rats. Preventative supplementation with a probiotic combination containing and could protect CS rats against an allergic response to OVA, indicating that the microbiota dysbiosis contributes to CS-related response. Additionally, probiotic intervention early in life might help to rebuild aberrant Th2 responses and tight junction proteins, both of which have been linked to CS-related high allergic reactions. Taken together, this study shows that disordered intestinal microbiota plays an essential role in the pathogenesis of food allergy mediated by CS. More importantly, interventions that modulate the microbiota composition in early life are therapeutically relevant for CS-related food allergies.
Delivery by cesarean section (CS) is linked to an increased incidence of food allergies in children and affects early gut microbiota colonization. Furthermore, emerging evidence has connected disordered intestinal microbiota to food allergies. Here, we investigated the impact of CS on a rat model for food allergy to ovalbumin (OVA). Rats delivered by CS were found to be more responsive to OVA sensitization than vaginally born ones, displaying a greater reduction in rectal temperature upon challenge, worse diarrhea, and higher levels of OVA-specific antibodies and histamine. 16S rRNA sequencing of feces revealed reduced levels of Lactobacillus and Bifidobacterium in the CS rats. Preventative supplementation with a probiotic combination containing Lactobacillus and Bifidobacterium could protect CS rats against an allergic response to OVA, indicating that the microbiota dysbiosis contributes to CS-related response. Additionally, probiotic intervention early in life might help to rebuild aberrant Th2 responses and tight junction proteins, both of which have been linked to CS-related high allergic reactions. Taken together, this study shows that disordered intestinal microbiota plays an essential role in the pathogenesis of food allergy mediated by CS. More importantly, interventions that modulate the microbiota composition in early life are therapeutically relevant for CS-related food allergies.
Author Li, Xiao-Yu
Li, Zhen
Jin, Bi-Ying
Li, Yan
Li, Li-Xiang
Zhao, Zi-Xiao
Li, Shi-Yang
Xia, Ya-Nan
Li, Yan-Qing
Fu, Shi-Chen
Li, Bing
Zhou, Ru-Chen
AuthorAffiliation 4 Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University , Jinan , China
2 Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University , Jinan , China
3 Robot Engineering Laboratory for Precise Diagnosis and Therapy of Gastrointestinal Tumor, Qilu Hospital of Shandong University , Jinan , China
1 Department of Gastroenterology, Qilu Hospital of Shandong University , Jinan , China
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Cites_doi 10.1073/pnas.1002601107
10.1038/s41386-021-01040-3
10.7554/eLife.00458
10.1038/pr.2018.34
10.1111/cea.12116
10.3109/00365521.2010.525716
10.1111/pai.12552
10.1097/AOG.0000000000002402
10.1038/pr.2014.156
10.1159/000324673
10.1159/000321110
10.3389/fphar.2012.00171
10.1139/cjpp-2019-0370
10.4168/aair.2016.8.5.471
10.1097/00005176-200404000-00004
10.1080/09540100500244138
10.1016/j.jaci.2017.02.007
10.1038/s41591-019-0461-z
10.1111/j.1365-2222.2008.02939.x
10.1002/jsfa.9993
10.1542/peds.2014-0596
10.1111/j.1365-2222.2008.03156.x
10.1111/pai.12522
10.1007/s00253-018-9217-9
10.1016/j.jaci.2018.06.044
10.1016/j.cub.2020.07.044
10.1016/j.micpath.2018.05.007
10.1016/j.femsec.2005.03.001
10.1016/j.jaci.2016.02.004
10.1136/gutjnl-2012-303249
10.1097/00005176-199901000-00007
10.1016/j.cell.2005.05.007
10.1016/S0140-6736(18)31928-7
10.1111/j.1399-3038.2008.00731.x
10.3390/ijms15021915
10.3390/ijms19051447
10.3109/00365521.2014.910834
10.1038/s41591-018-0324-z
10.1038/s41586-019-1560-1
10.1111/pai.12904
10.1016/j.jaci.2017.11.019
10.3389/fmicb.2017.01162
10.1016/j.molmed.2016.04.003
10.1126/scitranslmed.aax9929
10.5217/ir.2015.13.1.11
10.1034/j.1399-3038.2003.00072.x
10.12932/AP0443.32.4.2014
10.1001/jamapediatrics.2017.0378
10.1152/ajpcell.1999.276.5.C1046
10.1111/j.1574-6941.2010.01035.x
10.1016/j.jaci.2012.10.026
10.1016/j.jaci.2010.09.020
10.1074/jbc.M003516200
10.1038/s41385-019-0207-8
10.4049/jimmunol.1800666
10.1016/j.anaerobe.2007.11.002
10.1016/j.jaci.2011.10.004
10.1017/S000711451100479X
10.1038/nm.4039
10.1542/peds.2016-3000
10.1111/j.1398-9995.2007.01462.x
10.1007/s12038-012-9268-5
10.1111/all.13790
10.1084/jem.182.6.1871
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Keywords intestinal microbiota
cesarean section
Th2 response
food allergy
tight junction
probiotics
Language English
License Copyright © 2021 Jin, Li, Xia, Li, Zhao, Li, Li, Li, Zhou, Fu, Li and Li.
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These authors have contributed equally to this work and share senior authorship
Edited by: Tanima Bose, Ludwig Maximilian University of Munich, Germany
Reviewed by: Kathryn A. Knoop, Mayo Clinic, United States; Bo Yang, Jiangnan University, China
This article was submitted to Mucosal Immunity, a section of the journal Frontiers in Immunology
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References Dominguez-Bello (B20) 2010; 107
Jung (B45) 2019; 99
Scudamore (B55) 1995; 182
Rautava (B16) 2004; 38
Toh (B26) 2012; 3
Li (B6) 2014; 49
Underwood (B33) 2015; 77
Escribano (B35) 2018; 83
Berin (B58) 1999; 276
Roze (B34) 2012; 107
Zhang (B36) 2018; 102
Hopkins (B32) 2005; 54
Sevelsted (B7) 2015; 135
Morais (B10) 2020; 30
Kourosh (B15) 2018; 29
Stiehm (B41) 2013; 43
Bager (B5) 2008; 38
Cabana (B37) 2017; 140
Torii (B38) 2011; 154
Noval Rivas (B19) 2013; 131
Berni Canani (B31) 2012; 129
Coppola (B40) 2005; 16
Bosmans (B44) 2019; 74
Gronlund (B62) 1999; 28
Sjogren (B14) 2009; 39
Rodriguez (B17) 2011; 76
Feehley (B18) 2019; 25
Mitsou (B29) 2008; 14
Mohamadi-Jorjafki (B64) 2020; 98
Dominguez-Bello (B30) 2016; 22
Lee (B49) 2016; 8
Pizzuti (B54) 2011; 46
Pandey (B28) 2012; 37
Chinthrajah (B47) 2016; 137
Chen (B13) 2016; 27
Chen (B42) 2014; 32
Lee (B43) 2015; 13
Jakobsson (B61) 2014; 63
Zachariassen (B9) 2019; 202
Avery (B12) 2003; 14
Huang (B59) 2017; 139
Mazmanian (B52) 2005; 122
Castro (B39) 2012; 157
Gupta (B24) 2017; 8
Becattini (B22) 2016; 22
Ceponis (B57) 2000; 275
Maradiaga (B63) 2018; 121
Abdel-Gadir (B50) 2019; 25
Koplin (B3) 2008; 19
Song (B23) 2013; 2
Ellenbogen (B53) 2018; 19
Zachariassen (B8) 2019; 12
Shao (B25) 2019; 574
Papathoma (B46) 2016; 27
Tulic (B51) 2011; 127
Penders (B48) 2007; 62
Mitselou (B2) 2018; 142
Boerma (B1) 2018; 392
Stokholm (B4) 2020; 12
Pannaraj (B21) 2017; 171
(B60) 2017; 130
Zhao (B56) 2014; 15
Renz (B27) 2018; 141
Morais (B11) 2021; 46
References_xml – volume: 107
  year: 2010
  ident: B20
  article-title: Delivery Mode Shapes the Acquisition and Structure of the Initial Microbiota Across Multiple Body Habitats in Newborns
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1002601107
– volume: 46
  year: 2021
  ident: B11
  article-title: Early-Life Oxytocin Attenuates the Social Deficits Induced by Caesarean-Section Delivery in the Mouse
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-021-01040-3
– volume: 2
  start-page: e00458
  year: 2013
  ident: B23
  article-title: Cohabiting Family Members Share Microbiota With One Another and With Their Dogs
  publication-title: Elife
  doi: 10.7554/eLife.00458
– volume: 83
  year: 2018
  ident: B35
  article-title: Bifidobacterium Longum Subsp Infantis CECT7210-Supplemented Formula Reduces Diarrhea in Healthy Infants: A Randomized Controlled Trial
  publication-title: Pediatr Res
  doi: 10.1038/pr.2018.34
– volume: 43
  year: 2013
  ident: B41
  article-title: A Novel Synthetic Lipopeptide is Allergy-Protective by the Induction of LPS-Tolerance
  publication-title: Clin Exp Allergy
  doi: 10.1111/cea.12116
– volume: 46
  year: 2011
  ident: B54
  article-title: In Vitro Model for IgE Mediated Food Allergy
  publication-title: Scand J Gastroenterol
  doi: 10.3109/00365521.2010.525716
– volume: 27
  year: 2016
  ident: B46
  article-title: Cesarean Section Delivery and Development of Food Allergy and Atopic Dermatitis in Early Childhood
  publication-title: Pediatr Allergy Immunol
  doi: 10.1111/pai.12552
– volume: 130
  year: 2017
  ident: B60
  article-title: Committee Opinion No. 725: Vaginal Seeding
  publication-title: Obstet Gynecol
  doi: 10.1097/AOG.0000000000002402
– volume: 77
  year: 2015
  ident: B33
  article-title: Bifidobacterium Longum Subspecies Infantis: Champion Colonizer of the Infant Gut
  publication-title: Pediatr Res
  doi: 10.1038/pr.2014.156
– volume: 157
  start-page: 11
  year: 2012
  ident: B39
  article-title: Preliminary Studies on the Prevention of the Ovalbumin-Induced Allergic Response by Enterococcus Faecalis CECT7121 in Mice
  publication-title: Int Arch Allergy Immunol
  doi: 10.1159/000324673
– volume: 154
  year: 2011
  ident: B38
  article-title: Effects of Oral Administration of Lactobacillus Acidophilus L-92 on the Symptoms and Serum Markers of Atopic Dermatitis in Children
  publication-title: Int Arch Allergy Immunol
  doi: 10.1159/000321110
– volume: 3
  year: 2012
  ident: B26
  article-title: Probiotic Therapy as a Novel Approach for Allergic Disease
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2012.00171
– volume: 98
  year: 2020
  ident: B64
  article-title: Mode of Delivery Alters Dental Pulp Nociception and Pain-Induced Changes in Cognitive Performance in Adults Male Rats
  publication-title: Can J Physiol Pharmacol
  doi: 10.1139/cjpp-2019-0370
– volume: 8
  year: 2016
  ident: B49
  article-title: Dynamics of Gut Microbiota According to the Delivery Mode in Healthy Korean Infants
  publication-title: Allergy Asthma Immunol Res
  doi: 10.4168/aair.2016.8.5.471
– volume: 38
  year: 2004
  ident: B16
  article-title: The Hygiene Hypothesis of Atopic Disease–an Extended Version
  publication-title: J Pediatr Gastroenterol Nutr
  doi: 10.1097/00005176-200404000-00004
– volume: 16
  year: 2005
  ident: B40
  article-title: Effect of Saccharomyces boulardii and Bacillus cereus var. toyoi on the Humoral and Cellular Response of Mice to Vaccines
  publication-title: Food Agric Immunol
  doi: 10.1080/09540100500244138
– volume: 139
  year: 2017
  ident: B59
  article-title: The Microbiome in Allergic Disease: Current Understanding and Future Opportunities-2017 PRACTALL Document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2017.02.007
– volume: 25
  year: 2019
  ident: B50
  article-title: Microbiota Therapy Acts via a Regulatory T Cell MyD88/RORgammat Pathway to Suppress Food Allergy
  publication-title: Nat Med
  doi: 10.1038/s41591-019-0461-z
– volume: 38
  year: 2008
  ident: B5
  article-title: Caesarean Delivery and Risk of Atopy and Allergic Disease: Meta-Analyses
  publication-title: Clin Exp Allergy
  doi: 10.1111/j.1365-2222.2008.02939.x
– volume: 99
  year: 2019
  ident: B45
  article-title: Silkworm Dropping Extract Regulates Food Allergy Symptoms via Inhibition of Th2-Related Responses in an Ovalbumin-Induced Food Allergy Model
  publication-title: J Sci Food Agric
  doi: 10.1002/jsfa.9993
– volume: 135
  year: 2015
  ident: B7
  article-title: Cesarean Section and Chronic Immune Disorders
  publication-title: Pediatrics
  doi: 10.1542/peds.2014-0596
– volume: 39
  year: 2009
  ident: B14
  article-title: Altered Early Infant Gut Microbiota in Children Developing Allergy Up to 5 Years of Age
  publication-title: Clin Exp Allergy
  doi: 10.1111/j.1365-2222.2008.03156.x
– volume: 27
  year: 2016
  ident: B13
  article-title: Alterations in the Gut Microbiotas of Children With Food Sensitization in Early Life
  publication-title: Pediatr Allergy Immunol
  doi: 10.1111/pai.12522
– volume: 102
  year: 2018
  ident: B36
  article-title: Roles and Applications of Probiotic Lactobacillus Strains
  publication-title: Appl Microbiol Biotechnol
  doi: 10.1007/s00253-018-9217-9
– volume: 142
  year: 2018
  ident: B2
  article-title: Cesarean Delivery, Preterm Birth, and Risk of Food Allergy: Nationwide Swedish Cohort Study of More Than 1 Million Children
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2018.06.044
– volume: 30
  start-page: 3761
  year: 2020
  ident: B10
  article-title: Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2020.07.044
– volume: 121
  start-page: 27
  year: 2018
  ident: B63
  article-title: Gastrointestinal Microbiota and Mucosal Immune Gene Expression in Neonatal Pigs Reared in a Cross-Fostering Model
  publication-title: Microb Pathog
  doi: 10.1016/j.micpath.2018.05.007
– volume: 54
  start-page: 77
  year: 2005
  ident: B32
  article-title: Characterisation of Intestinal Bacteria in Infant Stools Using Real-Time PCR and Northern Hybridisation Analyses
  publication-title: FEMS Microbiol Ecol
  doi: 10.1016/j.femsec.2005.03.001
– volume: 137
  year: 2016
  ident: B47
  article-title: Molecular and Cellular Mechanisms of Food Allergy and Food Tolerance
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2016.02.004
– volume: 63
  year: 2014
  ident: B61
  article-title: Decreased Gut Microbiota Diversity, Delayed Bacteroidetes Colonisation and Reduced Th1 Responses in Infants Delivered by Caesarean Section
  publication-title: Gut
  doi: 10.1136/gutjnl-2012-303249
– volume: 28
  start-page: 19
  year: 1999
  ident: B62
  article-title: Fecal Microflora in Healthy Infants Born by Different Methods of Delivery: Permanent Changes in Intestinal Flora After Cesarean Delivery
  publication-title: J Pediatr Gastroenterol Nutr
  doi: 10.1097/00005176-199901000-00007
– volume: 122
  year: 2005
  ident: B52
  article-title: An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
  publication-title: Cell
  doi: 10.1016/j.cell.2005.05.007
– volume: 392
  year: 2018
  ident: B1
  article-title: Global Epidemiology of Use of and Disparities in Caesarean Sections
  publication-title: Lancet
  doi: 10.1016/S0140-6736(18)31928-7
– volume: 19
  year: 2008
  ident: B3
  article-title: Is Caesarean Delivery Associated With Sensitization to Food Allergens and IgE-Mediated Food Allergy: A Systematic Review
  publication-title: Pediatr Allergy Immunol
  doi: 10.1111/j.1399-3038.2008.00731.x
– volume: 15
  year: 2014
  ident: B56
  article-title: Beta-Conglycinin Reduces the Tight Junction Occludin and ZO-1 Expression in IPEC-J2
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms15021915
– volume: 19
  year: 2018
  ident: B53
  article-title: The Initiation of Th2 Immunity Towards Food Allergens
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms19051447
– volume: 49
  year: 2014
  ident: B6
  article-title: Cesarean Delivery and Risk of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
  publication-title: Scand J Gastroenterol
  doi: 10.3109/00365521.2014.910834
– volume: 25
  year: 2019
  ident: B18
  article-title: Healthy Infants Harbor Intestinal Bacteria That Protect Against Food Allergy
  publication-title: Nat Med
  doi: 10.1038/s41591-018-0324-z
– volume: 574
  year: 2019
  ident: B25
  article-title: Stunted Microbiota and Opportunistic Pathogen Colonization in Caesarean-Section Birth
  publication-title: Nature
  doi: 10.1038/s41586-019-1560-1
– volume: 29
  year: 2018
  ident: B15
  article-title: Fecal Microbiome Signatures Are Different in Food-Allergic Children Compared to Siblings and Healthy Children
  publication-title: Pediatr Allergy Immunol
  doi: 10.1111/pai.12904
– volume: 141
  year: 2018
  ident: B27
  article-title: The Neonatal Window of Opportunity-Early Priming for Life
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2017.11.019
– volume: 8
  year: 2017
  ident: B24
  article-title: Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2017.01162
– volume: 22
  year: 2016
  ident: B22
  article-title: Antibiotic-Induced Changes in the Intestinal Microbiota and Disease
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2016.04.003
– volume: 12
  year: 2020
  ident: B4
  article-title: Delivery Mode and Gut Microbial Changes Correlate With an Increased Risk of Childhood Asthma
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.aax9929
– volume: 13
  year: 2015
  ident: B43
  article-title: Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases
  publication-title: Intest Res
  doi: 10.5217/ir.2015.13.1.11
– volume: 14
  year: 2003
  ident: B12
  article-title: Assessment of Quality of Life in Children With Peanut Allergy
  publication-title: Pediatr Allergy Immunol
  doi: 10.1034/j.1399-3038.2003.00072.x
– volume: 32
  year: 2014
  ident: B42
  article-title: Food Allergens Affect the Intestinal Tight Junction Permeability in Inducing Intestinal Food Allergy in Rats
  publication-title: Asian Pac J Allergy Immunol
  doi: 10.12932/AP0443.32.4.2014
– volume: 171
  year: 2017
  ident: B21
  article-title: Association Between Breast Milk Bacterial Communities and Establishment and Development of the Infant Gut Microbiome
  publication-title: JAMA Pediatr
  doi: 10.1001/jamapediatrics.2017.0378
– volume: 276
  year: 1999
  ident: B58
  article-title: Role for IL-4 in Macromolecular Transport Across Human Intestinal Epithelium
  publication-title: Am J Physiol
  doi: 10.1152/ajpcell.1999.276.5.C1046
– volume: 76
  year: 2011
  ident: B17
  article-title: Germ-Free Status and Altered Caecal Subdominant Microbiota Are Associated With a High Susceptibility to Cow’s Milk Allergy in Mice
  publication-title: FEMS Microbiol Ecol
  doi: 10.1111/j.1574-6941.2010.01035.x
– volume: 131
  year: 2013
  ident: B19
  article-title: A Microbiota Signature Associated With Experimental Food Allergy Promotes Allergic Sensitization and Anaphylaxis
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2012.10.026
– volume: 127
  year: 2011
  ident: B51
  article-title: Differences in Innate Immune Function Between Allergic and Nonallergic Children: New Insights Into Immune Ontogeny
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2010.09.020
– volume: 275
  year: 2000
  ident: B57
  article-title: Interleukins 4 and 13 Increase Intestinal Epithelial Permeability by a Phosphatidylinositol 3-Kinase Pathway. Lack of Evidence for STAT 6 Involvement
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M003516200
– volume: 12
  year: 2019
  ident: B8
  article-title: Cesarean Section Increases Sensitivity to Oxazolone-Induced Colitis in C57BL/6 Mice
  publication-title: Mucosal Immunol
  doi: 10.1038/s41385-019-0207-8
– volume: 202
  year: 2019
  ident: B9
  article-title: Cesarean Section Induces Microbiota-Regulated Immune Disturbances in C57BL/6 Mice
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1800666
– volume: 14
  start-page: 94
  year: 2008
  ident: B29
  article-title: Fecal Microflora of Greek Healthy Neonates
  publication-title: Anaerobe
  doi: 10.1016/j.anaerobe.2007.11.002
– volume: 129
  start-page: 580
  year: 2012
  ident: B31
  article-title: Effect of Lactobacillus GG on Tolerance Acquisition in Infants With Cow’s Milk Allergy: A Randomized Trial
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2011.10.004
– volume: 107
  year: 2012
  ident: B34
  article-title: An Alpha-Lactalbumin-Enriched and Symbiotic-Supplemented V. A Standard Infant Formula: A Multicentre, Double-Blind, Randomised Trial
  publication-title: Br J Nutr
  doi: 10.1017/S000711451100479X
– volume: 22
  year: 2016
  ident: B30
  article-title: Partial Restoration of the Microbiota of Cesarean-Born Infants via Vaginal Microbial Transfer
  publication-title: Nat Med
  doi: 10.1038/nm.4039
– volume: 140
  year: 2017
  ident: B37
  article-title: Early Probiotic Supplementation for Eczema and Asthma Prevention: A Randomized Controlled Trial
  publication-title: Pediatrics
  doi: 10.1542/peds.2016-3000
– volume: 62
  year: 2007
  ident: B48
  article-title: The Role of the Intestinal Microbiota in the Development of Atopic Disorders
  publication-title: Allergy
  doi: 10.1111/j.1398-9995.2007.01462.x
– volume: 37
  year: 2012
  ident: B28
  article-title: Comparative Analysis of Fecal Microflora of Healthy Full-Term Indian Infants Born With Different Methods of Delivery (Vaginal vs Cesarean): Acinetobacter sp. Prevalence in Vaginally Born Infants
  publication-title: J Biosci
  doi: 10.1007/s12038-012-9268-5
– volume: 74
  year: 2019
  ident: B44
  article-title: Vagus Nerve Stimulation Dampens Intestinal Inflammation in a Murine Model of Experimental Food Allergy
  publication-title: Allergy
  doi: 10.1111/all.13790
– volume: 182
  year: 1995
  ident: B55
  article-title: Release of the Mucosal Mast Cell Granule Chymase, Rat Mast Cell Protease-II, During Anaphylaxis Is Associated With the Rapid Development of Paracellular Permeability to Macromolecules in Rat Jejunum
  publication-title: J Exp Med
  doi: 10.1084/jem.182.6.1871
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Snippet Delivery by cesarean section (CS) is linked to an increased incidence of food allergies in children and affects early gut microbiota colonization. Furthermore,...
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StartPage 741371
SubjectTerms Allergens - immunology
Animals
Bifidobacterium - genetics
Bifidobacterium - immunology
Cells, Cultured
cesarean section
Cesarean Section - statistics & numerical data
Disease Models, Animal
Dysbiosis - prevention & control
Female
food allergy
Food Hypersensitivity - epidemiology
Food Hypersensitivity - prevention & control
Gastrointestinal Microbiome - immunology
Humans
Immunoglobulin E - blood
Immunology
intestinal microbiota
Lactobacillus - genetics
Lactobacillus - immunology
Male
Ovalbumin - immunology
Pregnancy
probiotics
Probiotics - administration & dosage
Rats
Rats, Sprague-Dawley
RNA, Ribosomal, 16S - genetics
Th2 Cells - immunology
Th2 response
tight junction
Tight Junctions - metabolism
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Title Probiotic Interventions Alleviate Food Allergy Symptoms Correlated With Cesarean Section: A Murine Model
URI https://www.ncbi.nlm.nih.gov/pubmed/34650564
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