Evolution of the Vagus Nerve Stimulation (VNS) Therapy System Technology for Drug-Resistant Epilepsy
The vagus nerve stimulation (VNS) Therapy® System is the first FDA-approved medical device therapy for the treatment of drug-resistant epilepsy. Over the past two decades, the technology has evolved through multiple iterations resulting in software-related updates and implantable lead and generator...
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| Published in | Frontiers in medical technology Vol. 3; p. 696543 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Switzerland
Frontiers Media S.A
26.08.2021
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| Abstract | The vagus nerve stimulation (VNS) Therapy® System is the first FDA-approved medical device therapy for the treatment of drug-resistant epilepsy. Over the past two decades, the technology has evolved through multiple iterations resulting in software-related updates and implantable lead and generator hardware improvements. Healthcare providers today commonly encounter a range of single- and dual-pin generators (models 100, 101, 102, 102R, 103, 104, 105, 106, 1000) and related programming systems (models 250, 3000), all of which have their own subtle, but practical differences. It can therefore be a daunting task to go through the manuals of these implant models for comparison, some of which are not readily available. In this review, we highlight the technological evolution of the VNS Therapy System with respect to device approval milestones and provide a comparison of conventional open-loop vs. the latest closed-loop generator models. Battery longevity projections and an in-depth examination of stimulation mode interactions are also presented to further differentiate amongst generator models. |
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| AbstractList | The vagus nerve stimulation (VNS) Therapy® System is the first FDA-approved medical device therapy for the treatment of drug-resistant epilepsy. Over the past two decades, the technology has evolved through multiple iterations resulting in software-related updates and implantable lead and generator hardware improvements. Healthcare providers today commonly encounter a range of single- and dual-pin generators (models 100, 101, 102, 102R, 103, 104, 105, 106, 1000) and related programming systems (models 250, 3000), all of which have their own subtle, but practical differences. It can therefore be a daunting task to go through the manuals of these implant models for comparison, some of which are not readily available. In this review, we highlight the technological evolution of the VNS Therapy System with respect to device approval milestones and provide a comparison of conventional open-loop vs. the latest closed-loop generator models. Battery longevity projections and an in-depth examination of stimulation mode interactions are also presented to further differentiate amongst generator models. The vagus nerve stimulation (VNS) Therapy® System is the first FDA-approved medical device therapy for the treatment of drug-resistant epilepsy. Over the past two decades, the technology has evolved through multiple iterations resulting in software-related updates and implantable lead and generator hardware improvements. Healthcare providers today commonly encounter a range of single- and dual-pin generators (models 100, 101, 102, 102R, 103, 104, 105, 106, 1000) and related programming systems (models 250, 3000), all of which have their own subtle, but practical differences. It can therefore be a daunting task to go through the manuals of these implant models for comparison, some of which are not readily available. In this review, we highlight the technological evolution of the VNS Therapy System with respect to device approval milestones and provide a comparison of conventional open-loop vs. the latest closed-loop generator models. Battery longevity projections and an in-depth examination of stimulation mode interactions are also presented to further differentiate amongst generator models.The vagus nerve stimulation (VNS) Therapy® System is the first FDA-approved medical device therapy for the treatment of drug-resistant epilepsy. Over the past two decades, the technology has evolved through multiple iterations resulting in software-related updates and implantable lead and generator hardware improvements. Healthcare providers today commonly encounter a range of single- and dual-pin generators (models 100, 101, 102, 102R, 103, 104, 105, 106, 1000) and related programming systems (models 250, 3000), all of which have their own subtle, but practical differences. It can therefore be a daunting task to go through the manuals of these implant models for comparison, some of which are not readily available. In this review, we highlight the technological evolution of the VNS Therapy System with respect to device approval milestones and provide a comparison of conventional open-loop vs. the latest closed-loop generator models. Battery longevity projections and an in-depth examination of stimulation mode interactions are also presented to further differentiate amongst generator models. |
| Author | Aydemir, Seyhmus Afra, Pegah Watson, Glenn David Robert Adamolekun, Bola |
| AuthorAffiliation | 4 LivaNova, Neuromodulation Unit , Houston, TX , United States 1 Department of Neurology, Weill-Cornell Medicine , New York, NY , United States 2 Department of Neurology, University of Utah School of Medicine , Salt Lake City, UT , United States 3 Department of Neurology, University of Tennessee Health Science Center , Memphis, TN , United States |
| AuthorAffiliation_xml | – name: 1 Department of Neurology, Weill-Cornell Medicine , New York, NY , United States – name: 2 Department of Neurology, University of Utah School of Medicine , Salt Lake City, UT , United States – name: 4 LivaNova, Neuromodulation Unit , Houston, TX , United States – name: 3 Department of Neurology, University of Tennessee Health Science Center , Memphis, TN , United States |
| Author_xml | – sequence: 1 givenname: Pegah surname: Afra fullname: Afra, Pegah – sequence: 2 givenname: Bola surname: Adamolekun fullname: Adamolekun, Bola – sequence: 3 givenname: Seyhmus surname: Aydemir fullname: Aydemir, Seyhmus – sequence: 4 givenname: Glenn David Robert surname: Watson fullname: Watson, Glenn David Robert |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35047938$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2021 Afra, Adamolekun, Aydemir and Watson. Copyright © 2021 Afra, Adamolekun, Aydemir and Watson. 2021 Afra, Adamolekun, Aydemir and Watson |
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| Keywords | drug-resistant epilepsy neuromodulation VNS vagus nerve stimulation medical device |
| Language | English |
| License | Copyright © 2021 Afra, Adamolekun, Aydemir and Watson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 This article was submitted to Diagnostic and Therapeutic Devices, a section of the journal Frontiers in Medical Technology Reviewed by: Ali Abdul Latif, Welfare hospital, Iraq; Sanjay Raghav, Monash University, Australia Edited by: Dinesh Kumar, RMIT University, Australia |
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| Title | Evolution of the Vagus Nerve Stimulation (VNS) Therapy System Technology for Drug-Resistant Epilepsy |
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