Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets

• Published in: Frontiers in physiology Vol. 12; p. 815842
• Main Authors: Racca, Francesca, Pellegatta, Gaia, Cataldo, Giuseppe, Vespa, Edoardo, Carlani, Elisa, Pelaia, Corrado, Paoletti, Giovanni, Messina, Maria Rita, Nappi, Emanuele, Canonica, Giorgio Walter, Repici, Alessandro, Heffler, Enrico
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.01.2022
• Subjects: eosinophilic esophagitis; pathophysiology; Physiology; precision medicine; therapeutic targets; type 2 inflammation; precision medicine; therapeutic targets; type 2 inflammation; eosinophilic esophagitis; pathophysiology

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation, whose incidence is rising. It significantly affects patients’ quality of life and, if...