Isothiocyanate from Broccoli, Sulforaphane, and Its Properties
Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially in broccoli sprouts. Glucoraphanin requires the plant enzyme myrosinase for converting it into sulforaphane. Sulfora...
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| Published in | Journal of medicinal food Vol. 22; no. 2; p. 121 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.02.2019
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially in broccoli sprouts. Glucoraphanin requires the plant enzyme myrosinase for converting it into sulforaphane. Sulforaphane is metabolized through mercapturic acid pathway, being conjugated with glutathione and undergoes further biotransformation, yielding metabolites. Sulforaphane is extensively investigated and is in the interest in medicine for its health benefits. It has been shown that sulforaphane may protect against various types of cancer, may also decrease the risk of cardiovascular disease, and help in autism and osteoporosis. Our review offers a short summary of interesting properties of sulforaphane. Both the in vitro and in vivo methods/models and clinical studies are mentioned. |
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| AbstractList | Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially in broccoli sprouts. Glucoraphanin requires the plant enzyme myrosinase for converting it into sulforaphane. Sulforaphane is metabolized through mercapturic acid pathway, being conjugated with glutathione and undergoes further biotransformation, yielding metabolites. Sulforaphane is extensively investigated and is in the interest in medicine for its health benefits. It has been shown that sulforaphane may protect against various types of cancer, may also decrease the risk of cardiovascular disease, and help in autism and osteoporosis. Our review offers a short summary of interesting properties of sulforaphane. Both the in vitro and in vivo methods/models and clinical studies are mentioned. |
| Author | Anzenbacher, Pavel Anzenbacherova, Eva Vanduchova, Alena |
| Author_xml | – sequence: 1 givenname: Alena surname: Vanduchova fullname: Vanduchova, Alena organization: 2 Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc , Olomouc, Czech Republic – sequence: 2 givenname: Pavel surname: Anzenbacher fullname: Anzenbacher, Pavel organization: 2 Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc , Olomouc, Czech Republic – sequence: 3 givenname: Eva surname: Anzenbacherova fullname: Anzenbacherova, Eva organization: 3 Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc , Olomouc, Czech Republic |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30372361$$D View this record in MEDLINE/PubMed |
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| Snippet | Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high... |
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| SubjectTerms | Animals Antineoplastic Agents, Phytogenic - therapeutic use Autistic Disorder - drug therapy Brassica - chemistry Glucosinolates - metabolism Humans Imidoesters - metabolism Isothiocyanates - chemistry Isothiocyanates - pharmacology Isothiocyanates - therapeutic use Neoplasms - prevention & control Osteoporosis - drug therapy |
| Title | Isothiocyanate from Broccoli, Sulforaphane, and Its Properties |
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