Identification of the Association Between Toll-Like Receptors and T-Cell Activation in Takayasu’s Arteritis

• Published in: Frontiers in immunology Vol. 12; p. 792901
• Main Authors: Tian, Yixiao, Huang, Biqing, Li, Jing, Tian, Xinping, Zeng, Xiaofeng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.01.2022
• Subjects: Adult; co-stimulatory molecule; disease activity; Female; Humans; immune checkpoint; Immunology; Lymphocyte Activation - immunology; Male; Middle Aged; T-cell activation; T-Lymphocytes - immunology; Takayasu Arteritis - immunology; Takayasu’s arteritis; Toll-like receptor; Toll-Like Receptors - immunology; co-stimulatory molecule; immune checkpoint; disease activity; miRNA - microRNA; Takayasu’s arteritis; biomarker; Toll-like receptor; T-cell activation

To explore the relationships between Toll-like receptors (TLRs) and the activation and differentiation of T-cells in Takayasu’s arteritis (TAK), using real-time fluorescence quantitative polymerase chain reaction, mRNA abundance of 29 target genes in peripheral blood mononuclear cells (PBMCs) were d...