Mycobacterium smegmatis Bacteria Expressing Mycobacterium tuberculosis-Specific Rv1954A Induce Macrophage Activation and Modulate the Immune Response

• Published in: Frontiers in cellular and infection microbiology Vol. 10; p. 564565
• Main Authors: Arora, Simran Kaur, Naqvi, Nilofer, Alam, Anwar, Ahmad, Javeed, Alsati, Basma Saud, Sheikh, Javaid Ahmad, Kumar, Prabin, Mitra, Dipendra Kumar, Rahman, Syed Asad, Hasnain, Seyed Ehtesham, Ehtesham, Nasreen Zafar
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.10.2020
• Subjects: Cellular and Infection Microbiology; host-pathogen interface; immune modulation; oxidative stress; signature protein; Th1 response; host-pathogen interface; Th1 response; immune modulation; signature protein; oxidative stress

( ), the intracellular pathogen causing tuberculosis, has developed mechanisms that endow infectivity and allow it to modulate host immune response for its survival. Genomic and proteomic analyses of non-pathogenic and pathogenic mycobacteria showed presence of genes and proteins that are specific t...