Trilobatin, a Natural Food Additive, Exerts Anti-Type 2 Diabetes Effect Mediated by Nrf2/ARE and IRS-1/GLUT2 Signaling Pathways

• Published in: Frontiers in pharmacology Vol. 13; p. 828473
• Main Authors: Shi, Yan-Ling, Zhang, Yue-Ping, Luo, Huan, Xu, Fan, Gao, Jian-Mei, Shi, Jing-Shan, Gong, Qi-Hai
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.01.2022
• Subjects: insulin resistance; insulin signaling transduction pathway; lipid metabolism; Nrf2/ARE signaling pathway; Pharmacology; T2DM; trilobatin; T2DM; insulin signaling transduction pathway; trilobatin; insulin resistance; Nrf2/ARE signaling pathway; lipid metabolism

Oxidative stress and aberrant insulin signaling transduction play vital roles in type 2 diabetes mellitus (T2DM). Our previous research has demonstrated that trilobatin (TLB), derived from the leaves of (Wall.), exhibits a potent antioxidative profile. In the current study, we investigated the anti-...