Potent candidates for Targeted Auger Therapy: Production and radiochemical considerations

Targeted Auger Therapy represents great potential for the therapy of diseases which require a high degree of selectivity on the cellular level (e.g. for therapy of metastatic cancers). Due to their high Linear Energy Transfer (LET), Auger emitters, combined with selective biological systems which en...

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Bibliographic Details
Published inNuclear medicine and biology Vol. 94-95; pp. 1 - 19
Main Authors Filosofov, Dmitry, Kurakina, Elena, Radchenko, Valery
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2021
Elsevier BV
Subjects
Animals
Augers
Chelation
Deoxyribonucleic acid
DNA
Electrons
Emitters
Energy transfer
Humans
Linear energy transfer (LET)
Metastases
Molecular Targeted Therapy - methods
Neoplasms - metabolism
Neoplasms - radiotherapy
Neoplasms - therapy
Potent candidates
Production
Radiochemistry
Radiochemistry - methods
Radioisotopes
Radioisotopes - chemistry
Radioisotopes - therapeutic use
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - therapeutic use
Selectivity
Targeted Auger Therapy
Therapy
Chelation
Targeted Auger Therapy
Potent candidates
Production
Radiochemistry
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Summary:Targeted Auger Therapy represents great potential for the therapy of diseases which require a high degree of selectivity on the cellular level (e.g. for therapy of metastatic cancers). Due to their high Linear Energy Transfer (LET), Auger emitters, combined with selective biological systems which enable delivery of radionuclides close to the DNA of the targeting cell, can be extremely selective and powerful treatment tools. There are two main aspects associated with the development of efficient radiopharmaceuticals based on Auger Emitters: a) the availability of suitable Auger-emitting radionuclides for therapy and b) the design of targeting vectors which can deliver Auger emitters into/close to the nucleus. In the present review, we address the first aspect by defining important parameters for the selection of radionuclides for application to Targeted Auger Therapy and form a categorized list of the most promising radionuclides, their possible production routes, and their use in the synthesis of radiopharmaceuticals.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0969-8051
1872-9614
1872-9614
DOI:10.1016/j.nucmedbio.2020.12.001