Hypoxia Activates Notch4 via ERK/JNK/P38 MAPK Signaling Pathways to Promote Lung Adenocarcinoma Progression and Metastasis

• Published in: Frontiers in cell and developmental biology Vol. 9; p. 780121
• Main Authors: Li, Xiaochen, Cao, Xiaopei, Zhao, Hanqiu, Guo, Mingzhou, Fang, Xiaoyu, Li, Ke, Qin, Lu, He, Yuanzhou, Liu, Xiansheng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.12.2021
• Subjects: apoptosis; Cell and Developmental Biology; hypoxia; lung adenocarcinoma; mitogen-activated protein kinase; Notch4; proliferation; Notch4; mitogen-activated protein kinase; hypoxia; proliferation; lung adenocarcinoma; migration; apoptosis

Hypoxia contributes to the progression and metastasis of lung adenocarcinoma (LUAD). However, the specific underlying molecular mechanisms have not been fully elucidated. Here we report that Notch4 is upregulated in lung tissue from lung cancer patients. Functionally, Hypoxia activates the expressio...