A Potential Target for Diabetic Vascular Damage: High Glucose-Induced Monocyte Extracellular Vesicles Impair Endothelial Cells by Delivering miR-142-5p

• Published in: Frontiers in bioengineering and biotechnology Vol. 10; p. 913791
• Main Authors: Zhang, Rui, Niu, Shuai, Rong, Zhihua, Li, Fengshi, Ni, Leng, Di, Xiao, Liu, Changwei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.05.2022
• Subjects: Bioengineering and Biotechnology; diabetes mellitus; endothelial damage; extracellular vesicles; miR-142-5p; monocytes; miR-142-5p; monocytes; diabetes mellitus; extracellular vesicles; endothelial damage

Endothelial dysfunction is a key accessory to diabetic cardiovascular complications, and the regulatory role of the extracellular vesicles (EVs) from the innate immune system is growing. We tested whether EVs derived from high glucose-induced monocytes could shuttle microRNAs and impair endothelial...