Modeling of SGLT1 in Reconstituted Systems Reveals Apparent Ion-Dependencies of Glucose Uptake and Strengthens the Notion of Water-Permeable Apo States

• Published in: Frontiers in physiology Vol. 13; p. 874472
• Main Authors: Barta, Thomas, Sandtner, Walter, Wachlmayr, Johann, Hannesschlaeger, Christof, Ebert, Andrea, Speletz, Armin, Horner, Andreas
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 15.06.2022
• Subjects: glucose uptake; human sodium glucose co-transporter; lipid vesicles; mathematical modeling; Physiology; solute carrier; water-permeable apo states; passive membrane permeabilities; glucose uptake; human sodium glucose co-transporter; lipid vesicles; mathematical modeling; water-permeable apo states; solute carrier

The reconstitution of secondary active transporters into liposomes shed light on their molecular transport mechanism. The latter are either symporters, antiporters or exchangers, which use the energy contained in the electrochemical gradient of ions to fuel concentrative uptake of their cognate subs...