Metabolism and Hemoglobin Adduct Formation of Acrylamide in Humans

• Published in: Toxicological sciences Vol. 85; no. 1; pp. 447 - 459
• Main Authors: Fennell, Timothy R., Sumner, Susan C.J., Snyder, Rodney W., Burgess, Jason, Spicer, Rebecca, Bridson, William E., Friedman, Marvin A.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2005
• Subjects: acrylamide; Acrylamide - metabolism; Acrylamide - pharmacokinetics; Acrylamide - toxicity; adducts; Administration, Cutaneous; Administration, Oral; Adult; Aged; Animals; Carbon Isotopes; Dose-Response Relationship, Drug; Epoxy Compounds - metabolism; glycidamide; hemoglobin; Hemoglobins - drug effects; Hemoglobins - metabolism; Hemoglobins - physiology; Humans; Inactivation, Metabolic; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Rats; Rats, Inbred F344

Acrylamide (AM), used in the manufacture of polyacrylamide and grouting agents, is produced during the cooking of foods. Workplace exposure to AM can occur through the dermal and inhalation routes. The objectives of this study were to evaluate the metabolism of AM in humans following oral administra...