SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuated nef variant

• Published in: eLife Vol. 12
• Main Authors: Yamamoto, Hiroyuki, Matano, Tetsuro
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 03.03.2025; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: 1-Phosphatidylinositol 3-kinase; Acquired immune deficiency syndrome; AIDS; Animals; Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; B-Lymphocytes - immunology; Biological research; Biology, Experimental; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Haplotypes; HIV; Human immunodeficiency virus; Humans; Immune system; Immunology and Inflammation; immunosignaling; Infections; Kinases; Lymphocytes B; Lymphocytes T; Macaca mulatta; Microbiology and Infectious Disease; Mutation; Nef; neutralizing antibody; Phosphatidylinositol 3-Kinases - metabolism; Phosphoinositides; Phosphotransferases; PI3K; Plasma; Rapamycin; Simian Acquired Immunodeficiency Syndrome - immunology; Simian Acquired Immunodeficiency Syndrome - virology; Simian immunodeficiency virus; Simian Immunodeficiency Virus - genetics; Simian Immunodeficiency Virus - immunology; SIV; TOR protein; Viral antibodies; Viral infections; Viral Regulatory and Accessory Proteins - genetics; Viral Regulatory and Accessory Proteins - immunology; Viruses; Japan; SIV; rhesus macaque; viruses; immunosignaling; HIV; PI3K; infectious disease; inflammation; microbiology; neutralizing antibody; immunology; Nef

HIV and simian immunodeficiency virus (SIV) infections are known for impaired neutralizing antibody (NAb) responses. While sequential virus–host B cell interaction appears to be basally required for NAb induction, driver molecular signatures predisposing to NAb induction still remain largely unknown...