SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuated nef variant - Yamamoto, Hiroyuki; Matano, Tetsuro (eLife, 2025)
Keywords: 1-Phosphatidylinositol 3-kinase; Acquired immune deficiency syndrome; AIDS; Animals; Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; B-Lymphocytes - immunology; Biological research; Biology, Experimental; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Haplotypes; HIV; Human immunodeficiency virus; Humans; Immune system; Immunology and Inflammation; immunosignaling; Infections; Kinases; Lymphocytes B; Lymphocytes T; Macaca mulatta; Microbiology and Infectious Disease; Mutation; Nef; neutralizing antibody; Phosphatidylinositol 3-Kinases - metabolism; Phosphoinositides; Phosphotransferases; PI3K; Plasma; Rapamycin; Simian Acquired Immunodeficiency Syndrome - immunology; Simian Acquired Immunodeficiency Syndrome - virology; Simian immunodeficiency virus; Simian Immunodeficiency Virus - genetics; Simian Immunodeficiency Virus - immunology; SIV; TOR protein; Viral antibodies; Viral infections; Viral Regulatory and Accessory Proteins - genetics; Viral Regulatory and Accessory Proteins - immunology; Viruses; Japan; SIV; rhesus macaque; viruses; immunosignaling; HIV; PI3K; infectious disease; inflammation; microbiology; neutralizing antibody; immunology; Nef