Bayesian Physics-Based Modeling of Tau Propagation in Alzheimer's Disease

• Published in: Frontiers in physiology Vol. 12; p. 702975
• Main Authors: Schäfer, Amelie, Peirlinck, Mathias, Linka, Kevin, Kuhl, Ellen
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.07.2021
• Subjects: Alzheimer's disease; Bayesian inference; hierarchical modeling; network diffusion model; Physiology; tau PET; uncertainty quantification; network diffusion model; uncertainty quantification; Bayesian inference; Alzheimer's disease; hierarchical modeling; tau PET

Amyloid-β and hyperphosphorylated tau protein are known drivers of neuropathology in Alzheimer's disease. Tau in particular spreads in the brains of patients following a spatiotemporal pattern that is highly sterotypical and correlated with subsequent neurodegeneration. Novel medical imaging te...