Leukocyte filtration to decrease the number of adherent leukocytes in the cerebral microcirculation after a period of deep hypothermic circulatory arrest

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 132; no. 6; pp. 1339 - 1347.e1
• Main Authors: Alaoja, Hanna, Niemelä, Eija, Anttila, Vesa, Dahlbacka, Sebastian, Mäkelä, Jussi, Kiviluoma, Kai, Laurila, Päivi, Kaakinen, Timo, Juvonen, Tatu
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Mosby, Inc 01.12.2006; AATS/WTSA; Elsevier
• Subjects: Animals; Biological and medical sciences; Brain - blood supply; Cardiopulmonary Bypass; Cell Adhesion; Cerebrovascular Circulation; Circulatory Arrest, Deep Hypothermia Induced; Leukocyte Reduction Procedures; Leukocytes - physiology; Medical sciences; Microcirculation; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Swine; 19; 25; CPB; HCA; Heart; Prisoner; Filtration; Carceral environment; Arrest; Leukocyte; Period; Thorax; Encephalon; Microcirculation; Treatment; Decrease; Number; Surgery; Legal aspect

Cardiopulmonary bypass and hypothermic circulatory arrest induce a systemic inflammatory response, including a cascade of leukocyte and endothelial cell activity, during the postischemic reperfusion phase. Accumulation of leukocytes in the brain can lead to neurologic problems after cardiac surgery....