Tumor Necrosis Factor Receptors: Pleiotropic Signaling Complexes and Their Differential Effects

• Published in: Frontiers in immunology Vol. 11; p. 585880
• Main Authors: Gough, Portia, Myles, Ian A.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 25.11.2020
• Subjects: epithelial to mesenchymal transition; Immunology; NF-kappa B; signaling/signaling pathways; TNF; TNF blockade; TNF receptor; epithelial to mesenchymal transition; TNF receptor; NF-kappa B; signaling/signaling pathways; TNF; TNF blockade

Since its discovery in 1975, TNFα has been a subject of intense study as it plays significant roles in both immunity and cancer. Such attention is well deserved as TNFα is unique in its engagement of pleiotropic signaling via its two receptors: TNFR1 and TNFR2. Extensive research has yielded mechani...