Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells

• Published in: Oncotarget Vol. 8; no. 62; pp. 105536 - 105552
• Main Authors: Kang, Yu-Ting, Hsu, Wen-Cheng, Wu, Chih-Hsien, Hsin, I-Lun, Wu, Pei-Ru, Yeh, Kun-Tu, Ko, Jiunn-Liang
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 01.12.2017
• Subjects: Research Paper; nickel; lipocalin 2; metformin; autophagy; hexokinase 2

Autophagy is an intracellular recycling and degradation process for regulating tumor progression, survival and drug resistance. Nickel compounds have been identified as human carcinogens. However, the role of nickel-induced autophagy in lung carcinogenesis has not yet been fully elucidated. In this...