Large-Scale Single-Cell and Bulk Sequencing Analyses Reveal the Prognostic Value and Immune Aspects of CD147 in Pan-Cancer

• Published in: Frontiers in immunology Vol. 13; p. 810471
• Main Authors: Zhang, Jingwei, Wang, Zeyu, Zhang, Xun, Dai, Ziyu, Zhi-Peng, Wen, Yu, Jing, Peng, Yun, Wu, Wantao, Zhang, Nan, Luo, Peng, Zhang, Jian, Liu, Zaoqu, Feng, Songshan, Zhang, Hao, Cheng, Quan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.04.2022
• Subjects: CD147; Humans; Immune Checkpoint Proteins; Immunology; Immunotherapy; macrophages; Neoplasms - genetics; pan-cancer; Prognosis; tumor microenvironment; Tumor Microenvironment - genetics; macrophages; pan-cancer; tumor microenvironment; CD147; immunotherapy

CD147 plays an important role in promoting tumor proliferation and inhibiting cancer cell apoptosis in the tumor microenvironment. However, the mechanisms by which CD147 is involved in tumorigenesis remains unclear. This study systematically analyzed the prognostic value and immune characteristics o...