NMDAR Neurotransmission Needed for Persistent Neuronal Firing: Potential Roles in Mental Disorders

• Published in: Frontiers in psychiatry Vol. 12; p. 654322
• Main Authors: Yang, Shengtao, Seo, Hyojung, Wang, Min, Arnsten, Amy F T
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.04.2021
• Subjects: cingulate cortex; depression; NMDAR (NMDA receptor); prefrontal cortex; Psychiatry; working memory; cingulate cortex; depression; working memory; NMDAR (NMDA receptor); prefrontal cortex

The dorsolateral prefrontal cortex (dlPFC) generates the mental representations that are the foundation of abstract thought, and provides top-down regulation of emotion through projections to the medial PFC and cingulate cortices. Physiological recordings from dlPFC Delay cells have shown that the g...