High-Throughput Chinmedomics Strategy Discovers the Quality Markers and Mechanisms of Wutou Decoction Therapeutic for Rheumatoid Arthritis

• Published in: Frontiers in pharmacology Vol. 13; p. 854087
• Main Authors: Li, Taiping, Wu, Fangfang, Zhang, Aihua, Dong, Hui, Ullah, Ihsan, Lin, Hao, Miao, Jianhua, Sun, Hui, Han, Ying, He, Yanmei, Wang, Xijun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.04.2022
• Subjects: biomarker; chinmedomics; mass spectrometry; metabolomics; pathway; Pharmacology; quality markers; effective subustance; chinmedomics; metabolomics; mass spectrometry; pathway; biomarker; quality markers

Wutou decoction (WTD) is a traditional Chinese medicine prescription for the treatment of rheumatoid arthritis (RA), and this study systematically analyzed the metabolic mechanism and key pharmacodynamic components of WTD in RA rats by combining untargeted metabolomics and serum pharmacochemistry of...