High-Throughput Chinmedomics Strategy Discovers the Quality Markers and Mechanisms of Wutou Decoction Therapeutic for Rheumatoid Arthritis
Wutou decoction (WTD) is a traditional Chinese medicine prescription for the treatment of rheumatoid arthritis (RA), and this study systematically analyzed the metabolic mechanism and key pharmacodynamic components of WTD in RA rats by combining untargeted metabolomics and serum pharmacochemistry of...
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| Published in | Frontiers in pharmacology Vol. 13; p. 854087 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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12.04.2022
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| Abstract | Wutou decoction (WTD) is a traditional Chinese medicine prescription for the treatment of rheumatoid arthritis (RA), and this study systematically analyzed the metabolic mechanism and key pharmacodynamic components of WTD in RA rats by combining untargeted metabolomics and serum pharmacochemistry of traditional Chinese medicine to enrich the evidence of WTD quality markers (Q-markers) studies. WTD prevented synovial edema in RA rats and reduced tumor necrosis factor-alpha and interleukin 6 levels in rat serum, according to the results of an enzyme-linked immunosorbent examination and histopathological inspection. In model rats, pattern recognition and multivariate statistical analysis revealed 24 aberrant metabolites that disrupted linoleic acid metabolism, arachidonic acid metabolism, arginine and proline metabolism,
etc
. However, continued dosing of WTD for 28 days reversed 13 abnormal metabolites, which may be an important therapeutic mechanism from a metabolomic perspective. Importantly, 12 prototypical components and 16 metabolites from WTD were characterized in RA rat serum. The results of Pearson correlation analysis showed that aconitine, L-ephedrine, L-methylephedrine, quercetin, albiflorin, paeoniflorigenone, astragaline A, astragaloside II, glycyrrhetic acid, glycyrrhizic acid, licurazide, and isoliquiritigenin are the key pharmacological components that regulate the metabolism of RA rats, and they are identified as Q-markers. In sum, utilizing metabolomics and serum pharmacochemistry of traditional Chinese medicine, the metabolic mechanisms and Q-markers of WTD therapy in RA rats were revealed, providing a theoretical basis for the quality control investigation of WTD. |
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| AbstractList | Wutou decoction (WTD) is a traditional Chinese medicine prescription for the treatment of rheumatoid arthritis (RA), and this study systematically analyzed the metabolic mechanism and key pharmacodynamic components of WTD in RA rats by combining untargeted metabolomics and serum pharmacochemistry of traditional Chinese medicine to enrich the evidence of WTD quality markers (Q-markers) studies. WTD prevented synovial edema in RA rats and reduced tumor necrosis factor-alpha and interleukin 6 levels in rat serum, according to the results of an enzyme-linked immunosorbent examination and histopathological inspection. In model rats, pattern recognition and multivariate statistical analysis revealed 24 aberrant metabolites that disrupted linoleic acid metabolism, arachidonic acid metabolism, arginine and proline metabolism,
. However, continued dosing of WTD for 28 days reversed 13 abnormal metabolites, which may be an important therapeutic mechanism from a metabolomic perspective. Importantly, 12 prototypical components and 16 metabolites from WTD were characterized in RA rat serum. The results of Pearson correlation analysis showed that aconitine, L-ephedrine, L-methylephedrine, quercetin, albiflorin, paeoniflorigenone, astragaline A, astragaloside II, glycyrrhetic acid, glycyrrhizic acid, licurazide, and isoliquiritigenin are the key pharmacological components that regulate the metabolism of RA rats, and they are identified as Q-markers. In sum, utilizing metabolomics and serum pharmacochemistry of traditional Chinese medicine, the metabolic mechanisms and Q-markers of WTD therapy in RA rats were revealed, providing a theoretical basis for the quality control investigation of WTD. Wutou decoction (WTD) is a traditional Chinese medicine prescription for the treatment of rheumatoid arthritis (RA), and this study systematically analyzed the metabolic mechanism and key pharmacodynamic components of WTD in RA rats by combining untargeted metabolomics and serum pharmacochemistry of traditional Chinese medicine to enrich the evidence of WTD quality markers (Q-markers) studies. WTD prevented synovial edema in RA rats and reduced tumor necrosis factor-alpha and interleukin 6 levels in rat serum, according to the results of an enzyme-linked immunosorbent examination and histopathological inspection. In model rats, pattern recognition and multivariate statistical analysis revealed 24 aberrant metabolites that disrupted linoleic acid metabolism, arachidonic acid metabolism, arginine and proline metabolism, etc. However, continued dosing of WTD for 28 days reversed 13 abnormal metabolites, which may be an important therapeutic mechanism from a metabolomic perspective. Importantly, 12 prototypical components and 16 metabolites from WTD were characterized in RA rat serum. The results of Pearson correlation analysis showed that aconitine, L-ephedrine, L-methylephedrine, quercetin, albiflorin, paeoniflorigenone, astragaline A, astragaloside II, glycyrrhetic acid, glycyrrhizic acid, licurazide, and isoliquiritigenin are the key pharmacological components that regulate the metabolism of RA rats, and they are identified as Q-markers. In sum, utilizing metabolomics and serum pharmacochemistry of traditional Chinese medicine, the metabolic mechanisms and Q-markers of WTD therapy in RA rats were revealed, providing a theoretical basis for the quality control investigation of WTD. Wutou decoction (WTD) is a traditional Chinese medicine prescription for the treatment of rheumatoid arthritis (RA), and this study systematically analyzed the metabolic mechanism and key pharmacodynamic components of WTD in RA rats by combining untargeted metabolomics and serum pharmacochemistry of traditional Chinese medicine to enrich the evidence of WTD quality markers (Q-markers) studies. WTD prevented synovial edema in RA rats and reduced tumor necrosis factor-alpha and interleukin 6 levels in rat serum, according to the results of an enzyme-linked immunosorbent examination and histopathological inspection. In model rats, pattern recognition and multivariate statistical analysis revealed 24 aberrant metabolites that disrupted linoleic acid metabolism, arachidonic acid metabolism, arginine and proline metabolism, etc . However, continued dosing of WTD for 28 days reversed 13 abnormal metabolites, which may be an important therapeutic mechanism from a metabolomic perspective. Importantly, 12 prototypical components and 16 metabolites from WTD were characterized in RA rat serum. The results of Pearson correlation analysis showed that aconitine, L-ephedrine, L-methylephedrine, quercetin, albiflorin, paeoniflorigenone, astragaline A, astragaloside II, glycyrrhetic acid, glycyrrhizic acid, licurazide, and isoliquiritigenin are the key pharmacological components that regulate the metabolism of RA rats, and they are identified as Q-markers. In sum, utilizing metabolomics and serum pharmacochemistry of traditional Chinese medicine, the metabolic mechanisms and Q-markers of WTD therapy in RA rats were revealed, providing a theoretical basis for the quality control investigation of WTD. Wutou decoction (WTD) is a traditional Chinese medicine prescription for the treatment of rheumatoid arthritis (RA), and this study systematically analyzed the metabolic mechanism and key pharmacodynamic components of WTD in RA rats by combining untargeted metabolomics and serum pharmacochemistry of traditional Chinese medicine to enrich the evidence of WTD quality markers (Q-markers) studies. WTD prevented synovial edema in RA rats and reduced tumor necrosis factor-alpha and interleukin 6 levels in rat serum, according to the results of an enzyme-linked immunosorbent examination and histopathological inspection. In model rats, pattern recognition and multivariate statistical analysis revealed 24 aberrant metabolites that disrupted linoleic acid metabolism, arachidonic acid metabolism, arginine and proline metabolism, etc. However, continued dosing of WTD for 28 days reversed 13 abnormal metabolites, which may be an important therapeutic mechanism from a metabolomic perspective. Importantly, 12 prototypical components and 16 metabolites from WTD were characterized in RA rat serum. The results of Pearson correlation analysis showed that aconitine, L-ephedrine, L-methylephedrine, quercetin, albiflorin, paeoniflorigenone, astragaline A, astragaloside II, glycyrrhetic acid, glycyrrhizic acid, licurazide, and isoliquiritigenin are the key pharmacological components that regulate the metabolism of RA rats, and they are identified as Q-markers. In sum, utilizing metabolomics and serum pharmacochemistry of traditional Chinese medicine, the metabolic mechanisms and Q-markers of WTD therapy in RA rats were revealed, providing a theoretical basis for the quality control investigation of WTD.Wutou decoction (WTD) is a traditional Chinese medicine prescription for the treatment of rheumatoid arthritis (RA), and this study systematically analyzed the metabolic mechanism and key pharmacodynamic components of WTD in RA rats by combining untargeted metabolomics and serum pharmacochemistry of traditional Chinese medicine to enrich the evidence of WTD quality markers (Q-markers) studies. WTD prevented synovial edema in RA rats and reduced tumor necrosis factor-alpha and interleukin 6 levels in rat serum, according to the results of an enzyme-linked immunosorbent examination and histopathological inspection. In model rats, pattern recognition and multivariate statistical analysis revealed 24 aberrant metabolites that disrupted linoleic acid metabolism, arachidonic acid metabolism, arginine and proline metabolism, etc. However, continued dosing of WTD for 28 days reversed 13 abnormal metabolites, which may be an important therapeutic mechanism from a metabolomic perspective. Importantly, 12 prototypical components and 16 metabolites from WTD were characterized in RA rat serum. The results of Pearson correlation analysis showed that aconitine, L-ephedrine, L-methylephedrine, quercetin, albiflorin, paeoniflorigenone, astragaline A, astragaloside II, glycyrrhetic acid, glycyrrhizic acid, licurazide, and isoliquiritigenin are the key pharmacological components that regulate the metabolism of RA rats, and they are identified as Q-markers. In sum, utilizing metabolomics and serum pharmacochemistry of traditional Chinese medicine, the metabolic mechanisms and Q-markers of WTD therapy in RA rats were revealed, providing a theoretical basis for the quality control investigation of WTD. |
| Author | He, Yanmei Han, Ying Li, Taiping Sun, Hui Dong, Hui Miao, Jianhua Lin, Hao Wu, Fangfang Zhang, Aihua Ullah, Ihsan Wang, Xijun |
| AuthorAffiliation | 1 National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials , Guangxi Botanical Garden of Medicinal Plant , Nanning , China 2 National Chinmedomics Research Center , National TCM Key Laboratory of Serum Pharmacochemistry , Metabolomics Laboratory , Heilongjiang University of Chinese Medicine , Harbin , China |
| AuthorAffiliation_xml | – name: 2 National Chinmedomics Research Center , National TCM Key Laboratory of Serum Pharmacochemistry , Metabolomics Laboratory , Heilongjiang University of Chinese Medicine , Harbin , China – name: 1 National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials , Guangxi Botanical Garden of Medicinal Plant , Nanning , China |
| Author_xml | – sequence: 1 givenname: Taiping surname: Li fullname: Li, Taiping – sequence: 2 givenname: Fangfang surname: Wu fullname: Wu, Fangfang – sequence: 3 givenname: Aihua surname: Zhang fullname: Zhang, Aihua – sequence: 4 givenname: Hui surname: Dong fullname: Dong, Hui – sequence: 5 givenname: Ihsan surname: Ullah fullname: Ullah, Ihsan – sequence: 6 givenname: Hao surname: Lin fullname: Lin, Hao – sequence: 7 givenname: Jianhua surname: Miao fullname: Miao, Jianhua – sequence: 8 givenname: Hui surname: Sun fullname: Sun, Hui – sequence: 9 givenname: Ying surname: Han fullname: Han, Ying – sequence: 10 givenname: Yanmei surname: He fullname: He, Yanmei – sequence: 11 givenname: Xijun surname: Wang fullname: Wang, Xijun |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35496313$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_32604_biocell_2023_045986 crossref_primary_10_3389_fchem_2023_1142287 crossref_primary_10_3389_fphar_2024_1376812 crossref_primary_10_3390_molecules28237745 crossref_primary_10_1186_s13020_024_00917_x |
| Cites_doi | 10.1016/j.eng.2018.11.008 10.1016/j.phymed.2018.02.009 10.1016/B978-0-12-803117-9.00001-9 10.1016/j.jep.2021.114368 10.1016/j.jpba.2017.04.012 10.1016/j.lfs.2019.116956 10.1016/j.biocel.2012.04.003 10.1080/21655979.2021.1999554 10.1016/j.intimp.2012.03.005 10.1002/art.40504 10.1016/j.jep.2017.04.020 10.1016/j.pharmthera.2019.107452 10.1007/s00508-011-0103-z 10.1039/c7ra09522h 10.1039/c9ra09305b 10.1007/s11684-019-0705-9 10.1016/S1875-5364(15)30067-4 10.1016/j.bbrc.2018.03.117 10.3390/ijms21249628 10.1016/j.phymed.2018.02.008 10.1016/j.pharmthera.2020.107680 10.1016/j.phymed.2018.04.004 10.1586/1744666X.2014.917963 10.7501/j.issn.0253-2670.2014.10.013 10.1016/S0140-6736(01)06075-5 10.2174/1389201021666201229111825 10.1016/j.phymed.2018.01.017 10.1093/oxfordjournals.jbchem.a134668 10.1007/s10067-017-3896-y 10.1002/bmc.4724 10.1016/j.jphs.2017.01.007 10.1016/j.talanta.2013.09.054 10.1016/j.biopha.2020.109812 10.1016/j.biopha.2017.03.026 10.1016/j.phymed.2017.12.014 10.3389/fphar.2017.00230 10.1016/j.phymed.2018.04.015 |
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| Copyright | Copyright © 2022 Li, Wu, Zhang, Dong, Ullah, Lin, Miao, Sun, Han, He and Wang. Copyright © 2022 Li, Wu, Zhang, Dong, Ullah, Lin, Miao, Sun, Han, He and Wang. 2022 Li, Wu, Zhang, Dong, Ullah, Lin, Miao, Sun, Han, He and Wang |
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| Keywords | effective subustance chinmedomics metabolomics mass spectrometry pathway biomarker quality markers |
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| License | Copyright © 2022 Li, Wu, Zhang, Dong, Ullah, Lin, Miao, Sun, Han, He and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| References | Zheng (B37) 2012; 13 Piovezana Bossolani (B19) 2019; 238 Han (B12) 2020; 216 Qi (B21) 2014; 118 Zhang T (B35) 2018; 44 Xu (B28) 2017; 141 Moudgil (B17) 2014; 10 Zhang (B34) 2020; 34 Wang (B27) 2021; 279 Ahmed (B1) 2021; 22 Falconer (B8) 2018; 70 Zhang (B33) 2019; 5 Zhao (B36) 2020; 14 Qiu (B22) 2020; 10 Lee (B15) 2001; 358 Szczuko (B24) 2020; 21 Carlson (B3) 2018; 499 Dong (B7) 2015; 13 Zhang AH (B29) 2018; 45 Bai (B2) 2018; 44 Dai (B6) 2022; 13 Zhang (B32) 2017; 7 He (B13) 2018; 44 Wang (B26) 2019; 54 Haleagrahara (B11) 2017; 90 Puchner (B20) 2012; 124 Zhang (B31) 2014; 45 Imagawa (B14) 1984; 95 Li (B16) 2017; 133 Pan (B18) 2017; 205 Wang (B25) 2015 Guo (B9) 2017; 8 Guo (B10) 2020; 123 Charles-Schoeman (B5) 2018; 37 Sun (B23) 2019; 54 Zhang (B30) 2020; 207 Zhu (B38) 2012; 44 |
| References_xml | – volume: 5 start-page: 60 year: 2019 ident: B33 article-title: Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine publication-title: Engineering doi: 10.1016/j.eng.2018.11.008 – volume: 44 start-page: 204 year: 2018 ident: B35 article-title: The Method of Quality Marker Research and Quality Evaluation of Traditional Chinese Medicine Based on Drug Properties and Effect Characteristics publication-title: Phytomedicine doi: 10.1016/j.phymed.2018.02.009 – start-page: 1 volume-title: Chinmedomics year: 2015 ident: B25 article-title: Origin of Chinmedomics doi: 10.1016/B978-0-12-803117-9.00001-9 – volume: 279 start-page: 114368 year: 2021 ident: B27 article-title: Traditional Herbal Medicine: Therapeutic Potential in Rheumatoid Arthritis publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2021.114368 – volume: 141 start-page: 95 year: 2017 ident: B28 article-title: Systematically Characterize the Absorbed Effective Substances of Wutou Decoction and Their Metabolic Pathways in Rat Plasma Using UHPLC-Q-TOF-MS Combined with a Target Network Pharmacological Analysis publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2017.04.012 – volume: 238 start-page: 116956 year: 2019 ident: B19 article-title: Rheumatoid Arthritis Induces Enteric Neurodegeneration and Jejunal Inflammation, and Quercetin Promotes Neuroprotective and Anti-inflammatory Actions publication-title: Life Sci. doi: 10.1016/j.lfs.2019.116956 – volume: 44 start-page: 1139 year: 2012 ident: B38 article-title: Licorice Isoliquiritigenin Suppresses RANKL-Induced Osteoclastogenesis In Vitro and Prevents Inflammatory Bone Loss In Vivo publication-title: Int. J. Biochem. Cel Biol. doi: 10.1016/j.biocel.2012.04.003 – volume: 13 start-page: 268 year: 2022 ident: B6 article-title: Dehydroevodiamine Suppresses Inflammatory Responses in Adjuvant-Induced Arthritis Rats and Human Fibroblast-like Synoviocytes publication-title: Bioengineered doi: 10.1080/21655979.2021.1999554 – volume: 13 start-page: 46 year: 2012 ident: B37 article-title: Ephedrine Hydrochloride Protects Mice from LPS challenge by Promoting IL-10 Secretion and Inhibiting Proinflammatory Cytokines publication-title: Int. Immunopharmacol. doi: 10.1016/j.intimp.2012.03.005 – volume: 70 start-page: 984 year: 2018 ident: B8 article-title: Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis publication-title: Arthritis Rheumatol. doi: 10.1002/art.40504 – volume: 205 start-page: 1 year: 2017 ident: B18 article-title: Anti-rheumatoid Arthritis Effects of Traditional Chinese Herb Couple in Adjuvant-Induced Arthritis in Rats publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2017.04.020 – volume: 207 start-page: 107452 year: 2020 ident: B30 article-title: Anti-inflammatory and Immunoregulatory Effects of Paeoniflorin and Total Glucosides of Paeony publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2019.107452 – volume: 124 start-page: 170 year: 2012 ident: B20 article-title: Effects of 18β-Glycyrrhetinic Acid in hTNFtg Mice - a Model of Rheumatoid Arthritis publication-title: Wien. Klin. Wochenschr. doi: 10.1007/s00508-011-0103-z – volume: 7 start-page: 51069 year: 2017 ident: B32 article-title: Discovery and Verification of the Potential Targets from Bioactive Molecules by Network Pharmacology-Based Target Prediction Combined with High-Throughput Metabolomics publication-title: RSC Adv. doi: 10.1039/c7ra09522h – volume: 10 start-page: 2677 year: 2020 ident: B22 article-title: Functional Metabolomics Using UPLC-Q/TOF-MS Combined with Ingenuity Pathway Analysis as a Promising Strategy for Evaluating the Efficacy and Discovering Amino Acid Metabolism as a Potential Therapeutic Mechanism-Related Target for Geniposide against Alcoholic Liver Disease publication-title: RSC Adv. doi: 10.1039/c9ra09305b – volume: 14 start-page: 335 year: 2020 ident: B36 article-title: Chinmedomics Facilitated Quality-Marker Discovery of Sijunzi Decoction to Treat Spleen Qi Deficiency Syndrome publication-title: Front. Med. doi: 10.1007/s11684-019-0705-9 – volume: 13 start-page: 687 year: 2015 ident: B7 article-title: UPLC-Q-TOF/MS-based Metabolomic Studies on the Toxicity Mechanisms of Traditional Chinese Medicine Chuanwu and the Detoxification Mechanisms of Gancao, Baishao, and Ganjiang publication-title: Chin. J. Nat. Med. doi: 10.1016/S1875-5364(15)30067-4 – volume: 499 start-page: 182 year: 2018 ident: B3 article-title: Application of Global Metabolomic Profiling of Synovial Fluid for Osteoarthritis Biomarkers publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2018.03.117 – volume: 21 start-page: 9628 year: 2020 ident: B24 article-title: The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21249628 – volume: 44 start-page: 182 year: 2018 ident: B13 article-title: Discovery and Identification of Quality Markers of Chinese Medicine Based on Pharmacokinetic Analysis publication-title: Phytomedicine doi: 10.1016/j.phymed.2018.02.008 – volume: 216 start-page: 107680 year: 2020 ident: B12 article-title: Chinmedomics, a New Strategy for Evaluating the Therapeutic Efficacy of Herbal Medicines publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2020.107680 – volume: 45 start-page: 84 year: 2018 ident: B29 article-title: Identifying Quality-Markers from Shengmai San Protects against Transgenic Mouse Model of Alzheimer's Disease Using Chinmedomics Approach publication-title: Phytomedicine doi: 10.1016/j.phymed.2018.04.004 – volume: 10 start-page: 819 year: 2014 ident: B17 article-title: Traditional Chinese Medicine: Potential for Clinical Treatment of Rheumatoid Arthritis publication-title: Expert Rev. Clin. Immunol. doi: 10.1586/1744666X.2014.917963 – volume: 45 start-page: 1418 year: 2014 ident: B31 article-title: Effect of different compatibility of Daphnes Giraldii Cortex and Glycyrrhizae Radix et Rhizoma on adjuvant-induced arthritis in rats publication-title: Chin. Tradit. Herbal Drugs doi: 10.7501/j.issn.0253-2670.2014.10.013 – volume: 358 start-page: 903 year: 2001 ident: B15 article-title: Rheumatoid Arthritis publication-title: Lancet doi: 10.1016/S0140-6736(01)06075-5 – volume: 22 start-page: 2048 year: 2021 ident: B1 article-title: Bioactive Compounds with Significant Anti-Rheumatoid Arthritis Effect Isolated for the First Time from Leaves of Bougainvillea Spectabilis publication-title: Curr. Pharm. Biotechnol. doi: 10.2174/1389201021666201229111825 – volume: 44 start-page: 109 year: 2018 ident: B2 article-title: From Quality Markers to Data Mining and Intelligence Assessment: A Smart Quality-Evaluation Strategy for Traditional Chinese Medicine Based on Quality Markers publication-title: Phytomedicine doi: 10.1016/j.phymed.2018.01.017 – volume: 95 start-page: 771 year: 1984 ident: B14 article-title: Inhibition of Palmitate Oxidation in Mitochondria by Lipid Hydroperoxides publication-title: J. Biochem. doi: 10.1093/oxfordjournals.jbchem.a134668 – volume: 37 start-page: 615 year: 2018 ident: B5 article-title: High Levels of Oxidized Fatty Acids in HDL Are Associated with Impaired HDL Function in Patients with Active Rheumatoid Arthritis publication-title: Clin. Rheumatol. doi: 10.1007/s10067-017-3896-y – volume: 34 start-page: e4724 year: 2020 ident: B34 article-title: High-throughput Lipidomics Analysis to Discover Lipid Biomarkers and Profiles as Potential Targets for Evaluating Efficacy of Kai-Xin-San against APP/PS1 Transgenic Mice Based on UPLC-Q/TOF-MS publication-title: Biomed. Chromatogr. doi: 10.1002/bmc.4724 – volume: 133 start-page: 115 year: 2017 ident: B16 article-title: Aconitine: A Potential Novel Treatment for Systemic Lupus Erythematosus publication-title: J. Pharmacol. Sci. doi: 10.1016/j.jphs.2017.01.007 – volume: 118 start-page: 21 year: 2014 ident: B21 article-title: Chemical Profiling of Wu-tou Decoction by UPLC-Q-TOF-MS publication-title: Talanta doi: 10.1016/j.talanta.2013.09.054 – volume: 123 start-page: 109812 year: 2020 ident: B10 article-title: Antineuropathic Pain Actions of Wu-tou Decoction Resulted from the Increase of Neurotrophic Factor and Decrease of CCR5 Expression in Primary Rat Glial Cells publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2020.109812 – volume: 90 start-page: 38 year: 2017 ident: B11 article-title: Therapeutic Effect of Quercetin in Collagen-Induced Arthritis publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2017.03.026 – volume: 54 start-page: 371 year: 2019 ident: B26 article-title: Rapid Discovery of Quality-Markers from Kaixin San Using Chinmedomics Analysis Approach publication-title: Phytomedicine doi: 10.1016/j.phymed.2017.12.014 – volume: 8 start-page: 230 year: 2017 ident: B9 article-title: Wu-Tou Decoction in Rheumatoid Arthritis: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation publication-title: Front. Pharmacol. doi: 10.3389/fphar.2017.00230 – volume: 54 start-page: 328 year: 2019 ident: B23 article-title: High-throughput Chinmedomics Strategy for Discovering the Quality-Markers and Potential Targets for Yinchenhao Decoction publication-title: Phytomedicine doi: 10.1016/j.phymed.2018.04.015 |
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| Title | High-Throughput Chinmedomics Strategy Discovers the Quality Markers and Mechanisms of Wutou Decoction Therapeutic for Rheumatoid Arthritis |
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