α-Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects

• Published in: Neuropathology and applied neurobiology Vol. 32; no. 3; pp. 284 - 295
• Main Authors: Bloch, A., Probst, A., Bissig, H., Adams, H., Tolnay, M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2006; Blackwell Science
• Subjects: Aged; Aged, 80 and over; alpha-Synuclein - metabolism; autonomic nervous system; Biological and medical sciences; Brain - metabolism; Brain - pathology; Diseases of striated muscles. Neuromuscular diseases; Female; Human viral diseases; Humans; Immunohistochemistry; incidental Lewy body disease; Infectious diseases; Lewy bodies; Lewy neurites; Male; Medical sciences; Middle Aged; Neurology; Olfactory Nerve - metabolism; Olfactory Nerve - pathology; Parkinson's disease; Peripheral Nervous System - metabolism; Peripheral Nervous System - pathology; Spinal Cord - metabolism; Spinal Cord - pathology; Viral diseases; Viral diseases of the nervous system; α-synuclein; Human; Peripheral nervous system; Nervous system diseases; Neurite; Parkinson's disease; Lewy body disease; Parkinson disease; Cerebral disorder; Lewy bodies; Anatomic pathology; Autonomic nervous system; incidental Lewy body disease; Central nervous system disease; Lewy neurites; Degenerative disease; Elderly; α-synuclein; Extrapyramidal syndrome; Lewy body

Studies on cases with incidental Lewy body disease (ILBD) suggest that α‐synuclein (αSN) pathology of Parkinson's disease (PD) starts in lower brainstem nuclei and in the olfactory bulb. However, medullary structures as the induction site of αSN pathology have been questioned as large parts of...