Emerging Safety of Intramedullary Transplantation of Human Neural Stem Cells in Chronic Cervical and Thoracic Spinal Cord Injury

• Published in: Neurosurgery Vol. 82; no. 4; pp. 562 - 575
• Main Authors: Levi, Allan D, Okonkwo, David O, Park, Paul, Jenkins, Arthur L, Kurpad, Shekar N, Parr, Ann M, Ganju, Aruna, Aarabi, Bizhan, Kim, Dong, Casha, Steven, Fehlings, Michael G, Harrop, James S, Anderson, Kim D, Gage, Allyson, Hsieh, Jane, Huhn, Stephen, Curt, Armin, Guzman, Raphael
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2018; Copyright by the Congress of Neurological Surgeons; Wolters Kluwer Health, Inc
• Subjects: Adult; Cervical Cord - surgery; Female; Humans; Male; Middle Aged; Neural Stem Cells - transplantation; Neurosurgery; Spinal Cord - surgery; Spinal cord injuries; Spinal Cord Injuries - surgery; Stem cell transplantation; Stem Cell Transplantation - adverse effects; Stem Cell Transplantation - methods; Stem cells; Transplants & implants; Young Adult; Injection; Thoracic; Spinal cord injury; Cervical; Stem cells

Abstract BACKGROUND Human central nervous system stem cells (HuCNS-SC) are multipotent adult stem cells with successful engraftment, migration, and region-appropriate differentiation after spinal cord injury (SCI). OBJECTIVE To present data on the surgical safety profile and feasibility of multiple...