Development of a predictive pharmacokinetic model for a novel cyclooxygenase-2 inhibitor - Kastrissios, H; Rohatagi, S; Moberly, J; Truitt, K; Gao, Y; Wada, R; Takahashi, M; Kawabata, K; Salazar, D (Journal of clinical pharmacology, 2006)
Keywords: Adult; Aryl Hydrocarbon Hydroxylases - genetics; Asian Continental Ancestry Group - genetics; Cyclooxygenase 2 Inhibitors - blood; Cyclooxygenase 2 Inhibitors - pharmacokinetics; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6 - genetics; Double-Blind Method; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases - genetics; Models, Biological; Phenotype; Pyrroles - blood; Pyrroles - pharmacokinetics; Sulfonamides - blood; Sulfonamides - pharmacokinetics