Zebrafish-As an integrative model for twenty-first century toxicity testing

• Published in: Birth defects research. Part C. Embryo today Vol. 93; no. 3; pp. 256 - 267
• Main Authors: Sipes, Nisha S., Padilla, Stephanie, Knudsen, Thomas B.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2011
• Subjects: Abnormalities, Drug-Induced - etiology; Animals; Danio rerio; developmental toxicity; Embryo, Nonmammalian - drug effects; Environmental Pollutants - toxicity; Female; Freshwater; History, 21st Century; Pregnancy; Rabbits; Rats; ToxCast; Toxicity Tests; ToxRefDB; Zebrafish - physiology; zebrafish embryo

The zebrafish embryo is a useful small model for investigating vertebrate development because of its transparency, low cost, transgenic and morpholino capabilities, conservation of cell signaling, and concordance with mammalian developmental phenotypes. From these advantages, the zebrafish embryo ha...