Poly (ε-caprolactone) scaffolds functionalized by grafting NGF and GRGD promote growth and differentiation of PC12 cells

Poly(ε‐caprolactone) (PCL) scaffolds functionalized by grafting nerve growth factor (NGF) and Asp‐Arg‐Gly‐Asp (GRGD)(PCL‐NGF/GRGD) for neural tissue engineering. The influences of PCL‐NGF/GRGD scaffolds on the growth and differentiation of PC12 cells were investigated. The successfully grafting NGF...

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Published inJournal of biomedical materials research. Part A Vol. 102; no. 2; pp. 315 - 323
Main Authors Chung, Tze-Wen, Lai, Dar-Ming, Chen, Shin-Der, Lin, Ya-I
Format Journal Article
LanguageEnglish
Published Hoboken, NJ Blackwell Publishing Ltd 01.02.2014
Wiley-Blackwell
Wiley Subscription Services, Inc
Subjects
Animals
Biological and medical sciences
Biomaterials
Biotechnology
Cell Differentiation
Fundamental and applied biological sciences. Psychology
GRGD
Health. Pharmaceutical industry
Immobilized Proteins - chemistry
Industrial applications and implications. Economical aspects
Materials Testing
Medical sciences
Miscellaneous
Nerve Growth Factor - chemistry
Nerve Tissue - cytology
Nerve Tissue - metabolism
neural tissue engineering
Neurosurgery
NGF
Oligopeptides - chemistry
PC12 cell
PC12 Cells
PCL scaffolds
Polyesters - chemistry
Rats
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Synergistic effect
Technology. Biomaterials. Equipments
Tissue Engineering
Tissue Scaffolds - chemistry
neural tissue engineering
Graft copolymer
Growth
Tissue engineering
PCL scaffolds
PC12 cell
Nerve growth factor
GRGD
Scaffold
NGF
Grafting
Lactone polymer
Aliphatic polymer
Biomaterial
Nervous tissue
Polycaprolactone
Nerve regeneration
Biomedical engineering
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Abstract Poly(ε‐caprolactone) (PCL) scaffolds functionalized by grafting nerve growth factor (NGF) and Asp‐Arg‐Gly‐Asp (GRGD)(PCL‐NGF/GRGD) for neural tissue engineering. The influences of PCL‐NGF/GRGD scaffolds on the growth and differentiation of PC12 cells were investigated. The successfully grafting NGF and GRGD into PCL‐CS scaffold were verified by FTIR spectra. The densities of GRGD and NGF in the scaffolds were about 2.10×10−1 μmol/cm2 and 1.51×10−3 nmol/cm2. Growths of PC12 cells in PCL‐GRGD and PCL/NGF‐GRGD scaffolds via MTS measurements were significantly higher (p < 0.01, n = 4) than that in PCL‐CS or PCL‐NGF ones for three days of cultivation that was consistent with SEM observations. Moreover, the differentiation of PC12 cells, induced by NGF at 50 ng/mL for four days, in PCL‐NGF/GRGD scaffolds were qualitatively more numbers and longer outgrowth of neurites than those in PCL‐CS, PCL‐GRGD, and PCL‐NGF ones by SEM observations. The synergistic effects of grafting both NGF and GRGD ligands to PCL‐CS scaffolds on the growth and differentiation of PC12 cells provide a new biomaterial for neural tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 315–323, 2014.
AbstractList Poly(ε-caprolactone) (PCL) scaffolds functionalized by grafting nerve growth factor (NGF) and Asp-Arg-Gly-Asp (GRGD)(PCL-NGF/GRGD) for neural tissue engineering. The influences of PCL-NGF/GRGD scaffolds on the growth and differentiation of PC12 cells were investigated. The successfully grafting NGF and GRGD into PCL-CS scaffold were verified by FTIR spectra. The densities of GRGD and NGF in the scaffolds were about 2.10×10(-1) μmol/cm(2) and 1.51×10(-3) nmol/cm(2) . Growths of PC12 cells in PCL-GRGD and PCL/NGF-GRGD scaffolds via MTS measurements were significantly higher (p < 0.01, n = 4) than that in PCL-CS or PCL-NGF ones for three days of cultivation that was consistent with SEM observations. Moreover, the differentiation of PC12 cells, induced by NGF at 50 ng/mL for four days, in PCL-NGF/GRGD scaffolds were qualitatively more numbers and longer outgrowth of neurites than those in PCL-CS, PCL-GRGD, and PCL-NGF ones by SEM observations. The synergistic effects of grafting both NGF and GRGD ligands to PCL-CS scaffolds on the growth and differentiation of PC12 cells provide a new biomaterial for neural tissue engineering.
Poly([epsi]-caprolactone) (PCL) scaffolds functionalized by grafting nerve growth factor (NGF) and Asp-Arg-Gly-Asp (GRGD)(PCL-NGF/GRGD) for neural tissue engineering. The influences of PCL-NGF/GRGD scaffolds on the growth and differentiation of PC12 cells were investigated. The successfully grafting NGF and GRGD into PCL-CS scaffold were verified by FTIR spectra. The densities of GRGD and NGF in the scaffolds were about 2.10×10-1 µmol/cm2 and 1.51×10-3 nmol/cm2. Growths of PC12 cells in PCL-GRGD and PCL/NGF-GRGD scaffolds via MTS measurements were significantly higher (p < 0.01, n = 4) than that in PCL-CS or PCL-NGF ones for three days of cultivation that was consistent with SEM observations. Moreover, the differentiation of PC12 cells, induced by NGF at 50 ng/mL for four days, in PCL-NGF/GRGD scaffolds were qualitatively more numbers and longer outgrowth of neurites than those in PCL-CS, PCL-GRGD, and PCL-NGF ones by SEM observations. The synergistic effects of grafting both NGF and GRGD ligands to PCL-CS scaffolds on the growth and differentiation of PC12 cells provide a new biomaterial for neural tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 315-323, 2014.
Poly(ε‐caprolactone) (PCL) scaffolds functionalized by grafting nerve growth factor (NGF) and Asp‐Arg‐Gly‐Asp (GRGD)(PCL‐NGF/GRGD) for neural tissue engineering. The influences of PCL‐NGF/GRGD scaffolds on the growth and differentiation of PC12 cells were investigated. The successfully grafting NGF and GRGD into PCL‐CS scaffold were verified by FTIR spectra. The densities of GRGD and NGF in the scaffolds were about 2.10×10−1 μmol/cm2 and 1.51×10−3 nmol/cm2. Growths of PC12 cells in PCL‐GRGD and PCL/NGF‐GRGD scaffolds via MTS measurements were significantly higher (p < 0.01, n = 4) than that in PCL‐CS or PCL‐NGF ones for three days of cultivation that was consistent with SEM observations. Moreover, the differentiation of PC12 cells, induced by NGF at 50 ng/mL for four days, in PCL‐NGF/GRGD scaffolds were qualitatively more numbers and longer outgrowth of neurites than those in PCL‐CS, PCL‐GRGD, and PCL‐NGF ones by SEM observations. The synergistic effects of grafting both NGF and GRGD ligands to PCL‐CS scaffolds on the growth and differentiation of PC12 cells provide a new biomaterial for neural tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 315–323, 2014.
Poly(ε-caprolactone) (PCL) scaffolds functionalized by grafting nerve growth factor (NGF) and Asp-Arg-Gly-Asp (GRGD)(PCL-NGF/GRGD) for neural tissue engineering. The influences of PCL-NGF/GRGD scaffolds on the growth and differentiation of PC12 cells were investigated. The successfully grafting NGF and GRGD into PCL-CS scaffold were verified by FTIR spectra. The densities of GRGD and NGF in the scaffolds were about 2.10×10(-1) μmol/cm(2) and 1.51×10(-3) nmol/cm(2) . Growths of PC12 cells in PCL-GRGD and PCL/NGF-GRGD scaffolds via MTS measurements were significantly higher (p < 0.01, n = 4) than that in PCL-CS or PCL-NGF ones for three days of cultivation that was consistent with SEM observations. Moreover, the differentiation of PC12 cells, induced by NGF at 50 ng/mL for four days, in PCL-NGF/GRGD scaffolds were qualitatively more numbers and longer outgrowth of neurites than those in PCL-CS, PCL-GRGD, and PCL-NGF ones by SEM observations. The synergistic effects of grafting both NGF and GRGD ligands to PCL-CS scaffolds on the growth and differentiation of PC12 cells provide a new biomaterial for neural tissue engineering.Poly(ε-caprolactone) (PCL) scaffolds functionalized by grafting nerve growth factor (NGF) and Asp-Arg-Gly-Asp (GRGD)(PCL-NGF/GRGD) for neural tissue engineering. The influences of PCL-NGF/GRGD scaffolds on the growth and differentiation of PC12 cells were investigated. The successfully grafting NGF and GRGD into PCL-CS scaffold were verified by FTIR spectra. The densities of GRGD and NGF in the scaffolds were about 2.10×10(-1) μmol/cm(2) and 1.51×10(-3) nmol/cm(2) . Growths of PC12 cells in PCL-GRGD and PCL/NGF-GRGD scaffolds via MTS measurements were significantly higher (p < 0.01, n = 4) than that in PCL-CS or PCL-NGF ones for three days of cultivation that was consistent with SEM observations. Moreover, the differentiation of PC12 cells, induced by NGF at 50 ng/mL for four days, in PCL-NGF/GRGD scaffolds were qualitatively more numbers and longer outgrowth of neurites than those in PCL-CS, PCL-GRGD, and PCL-NGF ones by SEM observations. The synergistic effects of grafting both NGF and GRGD ligands to PCL-CS scaffolds on the growth and differentiation of PC12 cells provide a new biomaterial for neural tissue engineering.
Poly(ε‐caprolactone) (PCL) scaffolds functionalized by grafting nerve growth factor (NGF) and Asp‐Arg‐Gly‐Asp (GRGD)(PCL‐NGF/GRGD) for neural tissue engineering. The influences of PCL‐NGF/GRGD scaffolds on the growth and differentiation of PC12 cells were investigated. The successfully grafting NGF and GRGD into PCL‐CS scaffold were verified by FTIR spectra. The densities of GRGD and NGF in the scaffolds were about 2.10×10 −1 μmol/cm 2 and 1.51×10 −3 nmol/cm 2 . Growths of PC12 cells in PCL‐GRGD and PCL/NGF‐GRGD scaffolds via MTS measurements were significantly higher ( p < 0.01, n = 4) than that in PCL‐CS or PCL‐NGF ones for three days of cultivation that was consistent with SEM observations. Moreover, the differentiation of PC12 cells, induced by NGF at 50 ng/mL for four days, in PCL‐NGF/GRGD scaffolds were qualitatively more numbers and longer outgrowth of neurites than those in PCL‐CS, PCL‐GRGD, and PCL‐NGF ones by SEM observations. The synergistic effects of grafting both NGF and GRGD ligands to PCL‐CS scaffolds on the growth and differentiation of PC12 cells provide a new biomaterial for neural tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 315–323, 2014.
Author Chen, Shin-Der
Lin, Ya-I
Chung, Tze-Wen
Lai, Dar-Ming
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Cites_doi 10.1046/j.1469-7580.1999.19410001.x
10.1016/S0142-9612(03)00361-2
10.1016/j.biomaterials.2009.05.037
10.1002/jbm.a.31036
10.1016/j.actbio.2009.03.009
10.1016/S1389-1723(04)70221-2
10.1016/j.biomaterials.2010.09.023
10.1016/j.resp.2009.08.015
10.1016/S0304-3940(03)00915-7
10.1016/j.brainresrev.2004.11.002
10.1096/fj.02-0564fje
10.1089/ten.2005.11.1
10.1523/JNEUROSCI.02-08-01157.1982
10.1016/S0959-4388(99)00066-5
10.1146/annurev.neuro.24.1.1217
10.1016/0968-0004(91)90096-E
10.1146/annurev.bioeng.5.011303.120731
10.1007/s10856-009-3876-0
10.3109/02652048.2010.484104
10.1179/016164104225013798
10.1002/jbm.a.30225
10.1055/s-2007-1006407
10.1002/cne.20518
10.1021/bm070266z
10.1016/S0142-9612(02)00231-4
10.1007/s10856-008-3671-3
10.1146/annurev.neuro.24.1.677
10.1097/00019052-200312000-00011
10.1126/science.1850549
10.1016/0092-8674(91)90149-S
10.1002/jbm.b.31146
10.1002/jbm.a.31047
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Issue 2
Keywords neural tissue engineering
Graft copolymer
Growth
Tissue engineering
PCL scaffolds
PC12 cell
Nerve growth factor
GRGD
Scaffold
NGF
Grafting
Lactone polymer
Aliphatic polymer
Biomaterial
Nervous tissue
Polycaprolactone
Nerve regeneration
Biomedical engineering
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References Terzis JK, Sun DD, Thanos PK. Historical and basic science review: Past, present, and future of nerve repair. J Reconstr Microsurg 1997;13:215-225.
Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 1991;252( 5005):554-558.
Chung TW, Tyan YC, Yang JD. PCP copolymers grafted with RGD enhance the rates of RGD-PCP micelles internalized into cells. J Microencapsul 2010;27:514-520.
Brose K, Tessier-Lavigne M. Slit proteins: Key regulators of axon guidance, axonal branching, and cell migration. Curr Opin Neurobiol 2000;10:95-102.
Fujii DK, Massoglia SL, Savion N, Gospodarowicz D. Neurite outgrowth and protein synthesis by PC12 cells as a function of substratum and nerve growth factor. J Neurosci 1982;2:1157-1175.
Schmidt CE, Leach JB. Neural tissue engineering: Strategies for repair and regeneration. Ann Rev Biomed Eng 2003;5:293-347.
Cordon-Cardo C, Tapley P, Jing SQ, Nanduri V, O'Rourke E, Lamballe F, Kovary K, Klein R, Jones KR, Reichardt LF, Barbacid M. The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. Cell 1991;66:173-183.
Kokai LE, Lin YC, Oyster NM, Marra KG. Diffusion of soluble factors through degradable polymer nerve guides: Controlling manufacturing parameters. Acta Biomater 2009;5:2540-2550.
Chung TW, Yang MG, Liu DZ, Chen WP, Pan CI, Wang SS. Enhancing growth human endothelial cells on Arg-Gly-Asp (RGD) embedded poly (epsilon-caprolactone) (PCL) surface with nanometer scale of surface disturbance. J Biomed Mater Res A 2005;72:213-219.
Chung TW, Chang YL. Silk fibroin/chitosan-hyaluronic acid versus silk fibroin scaffolds for tissue engineering: promoting cell proliferations in vitro. J Mater Sci Mater Med 2010;21:1343-1351.
Mochizuki M, Kadoya Y, Wakabayashi Y, Kato K, Okazaki I, Yamada M, Sato T, Sakairi N, Nishi N, Nomizu M. Laminin-1 peptide-conjugated chitosan membranes as a novel approach for cell engineering. FASEB J 2003;17:875-877.
Novikova LN, Novikov LN, Kellerth JO. Biopolymers and biodegradable smart implants for tissue regeneration after spinal cord injury. Curr Opin Neurol 2003;16:711-715.
Belkas JS, Shoichet MS, Midha R. Peripheral nerve regeneration through guidance tubes. Neurol Res 2004;26:151-160.
Chung TW, Lu YF, Wang SS, Lin YS, Chu SH. Growth of human endothelial cells on photochemically grafted Gly-Arg-Gly-Asp (GRGD) chitosans. Biomaterials 2002;23:4803-4809.
Huang YC, Huang CC, Huang YY, Chen KS. Surface modification and characterization of chitosan or PLGA membrane with laminin by chemical and oxygen plasma treatment for neural regeneration. J Biomed Mater Res A 2007;82:842-851.
Sun W, Sun C, Lin H, Zhao H, Wang J, Ma H, Chen B, Xiao Z, Dai J. The effect of collagen-binding NGF-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model. Biomaterials 2009;30:4649-4656.
Huang EJ, Reichardt LF. Neurotrophins: roles in neuronal development and function. Ann Rev Neurosci 2001;24:677-736.
Wilson CJ, Clegg RE, Leavesley DI, Pearcy MJ. Mediation of biomaterial-cell interactions by adsorbed proteins: A review. Tissue Eng 2005;11:1-18.
Tucker BA, Rahimtula M, Mearow KM. Integrin activation and neurotrophin signaling cooperate to enhance neurite outgrowth in sensory neurons. J Comp Neurol 2005;486:267-280.
Chung TW, Liu DZ, Wang SY, Wang SS. Enhancement of the growth of human endothelial cells by surface roughness at nanometer scale. Biomaterials 2003;24:4655-4661.
Sun M, Downes S. Physicochemical characterisation of novel ultra-thin biodegradable scaffolds for peripheral nerve repair. J Mater Sci Mater Med 2009;20:1181-1192.
Chung TW, Yang MC, Tseng CC, Sheu SH, Wang SS, Huang YY, Chen SD. Promoting regeneration of peripheral nerves in-vivo using new PCL- NGF/Tirofiban nerve conduits. Biomaterials 2011;32:734-743.
Howe CL. Depolarization of PC12 cells induces neurite outgrowth and enhances nerve growth factor-induced neurite outgrowth in rats. Neurosci Lett 2003;351:41-45.
Pankajakshan D, Philipose LP, Palakkal M, Krishnan K, Krishnan LK. Development of a fibrin composite-coated poly(epsilon-caprolactone) scaffold for potential vascular tissue engineering applications. J Biomed Mater Res B Appl Biomater 2008;87:570-579.
Terenghi G. Peripheral nerve regeneration and neurotrophic factors. J Anat 1999;194 ( Pt 1):1-14.
Guo Y, Li M, Mylonakis A, Han J, MacDiarmid AG, Chen X, Lelkes PI, Wei Y. Electroactive oligoaniline-containing self-assembled monolayers for tissue engineering applications. Biomacromolecules 2007;8:3025-3034.
Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci 2001;24:1217-1281.
D'Souza SE, Ginsberg MH, Plow EF. Arginyl-glycyl-aspartic acid (RGD): A cell adhesion motif. Trends Biochem Sci 1991;16:246-250.
Yan QJ, Yin YX, Li BB. Use new PLGL-RGD-NGF nerve conduits for promoting peripheral nerve regeneration. Biomed Eng Online 2012;11.
Zhang N, Yan HH, Wen XJ. Tissue-engineering approaches for axonal guidance. Brain Res Rev 2005;49:48-64.
Madigan NN, McMahon S, O'Brien T, Yaszemski MJ, Windebank AJ. Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds. Respir Physiol Neurobiol 2009;169:183-199.
Gomez N, Schmidt CE. Nerve growth factor-immobilized polypyrrole: Bioactive electrically conducting polymer for enhanced neurite extension. J Biomed Mater Res A 2007;81A:135-149.
Park KH, Yun K. Immobilization of Arg-Gly-Asp (RGD) sequence in a thermosensitive hydrogel for cell delivery using pheochromocytoma cells (PC12). J Biosci Bioeng 2004;97:374-377.
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References_xml – reference: Chung TW, Liu DZ, Wang SY, Wang SS. Enhancement of the growth of human endothelial cells by surface roughness at nanometer scale. Biomaterials 2003;24:4655-4661.
– reference: Yan QJ, Yin YX, Li BB. Use new PLGL-RGD-NGF nerve conduits for promoting peripheral nerve regeneration. Biomed Eng Online 2012;11.
– reference: Zhang N, Yan HH, Wen XJ. Tissue-engineering approaches for axonal guidance. Brain Res Rev 2005;49:48-64.
– reference: Chung TW, Yang MC, Tseng CC, Sheu SH, Wang SS, Huang YY, Chen SD. Promoting regeneration of peripheral nerves in-vivo using new PCL- NGF/Tirofiban nerve conduits. Biomaterials 2011;32:734-743.
– reference: Brose K, Tessier-Lavigne M. Slit proteins: Key regulators of axon guidance, axonal branching, and cell migration. Curr Opin Neurobiol 2000;10:95-102.
– reference: Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 1991;252( 5005):554-558.
– reference: Belkas JS, Shoichet MS, Midha R. Peripheral nerve regeneration through guidance tubes. Neurol Res 2004;26:151-160.
– reference: Guo Y, Li M, Mylonakis A, Han J, MacDiarmid AG, Chen X, Lelkes PI, Wei Y. Electroactive oligoaniline-containing self-assembled monolayers for tissue engineering applications. Biomacromolecules 2007;8:3025-3034.
– reference: Huang YC, Huang CC, Huang YY, Chen KS. Surface modification and characterization of chitosan or PLGA membrane with laminin by chemical and oxygen plasma treatment for neural regeneration. J Biomed Mater Res A 2007;82:842-851.
– reference: Park KH, Yun K. Immobilization of Arg-Gly-Asp (RGD) sequence in a thermosensitive hydrogel for cell delivery using pheochromocytoma cells (PC12). J Biosci Bioeng 2004;97:374-377.
– reference: Chung TW, Lu YF, Wang SS, Lin YS, Chu SH. Growth of human endothelial cells on photochemically grafted Gly-Arg-Gly-Asp (GRGD) chitosans. Biomaterials 2002;23:4803-4809.
– reference: Sun W, Sun C, Lin H, Zhao H, Wang J, Ma H, Chen B, Xiao Z, Dai J. The effect of collagen-binding NGF-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model. Biomaterials 2009;30:4649-4656.
– reference: D'Souza SE, Ginsberg MH, Plow EF. Arginyl-glycyl-aspartic acid (RGD): A cell adhesion motif. Trends Biochem Sci 1991;16:246-250.
– reference: Wilson CJ, Clegg RE, Leavesley DI, Pearcy MJ. Mediation of biomaterial-cell interactions by adsorbed proteins: A review. Tissue Eng 2005;11:1-18.
– reference: Pankajakshan D, Philipose LP, Palakkal M, Krishnan K, Krishnan LK. Development of a fibrin composite-coated poly(epsilon-caprolactone) scaffold for potential vascular tissue engineering applications. J Biomed Mater Res B Appl Biomater 2008;87:570-579.
– reference: Terenghi G. Peripheral nerve regeneration and neurotrophic factors. J Anat 1999;194 ( Pt 1):1-14.
– reference: Terzis JK, Sun DD, Thanos PK. Historical and basic science review: Past, present, and future of nerve repair. J Reconstr Microsurg 1997;13:215-225.
– reference: Chung TW, Tyan YC, Yang JD. PCP copolymers grafted with RGD enhance the rates of RGD-PCP micelles internalized into cells. J Microencapsul 2010;27:514-520.
– reference: Huang EJ, Reichardt LF. Neurotrophins: roles in neuronal development and function. Ann Rev Neurosci 2001;24:677-736.
– reference: Gomez N, Schmidt CE. Nerve growth factor-immobilized polypyrrole: Bioactive electrically conducting polymer for enhanced neurite extension. J Biomed Mater Res A 2007;81A:135-149.
– reference: Novikova LN, Novikov LN, Kellerth JO. Biopolymers and biodegradable smart implants for tissue regeneration after spinal cord injury. Curr Opin Neurol 2003;16:711-715.
– reference: Kokai LE, Lin YC, Oyster NM, Marra KG. Diffusion of soluble factors through degradable polymer nerve guides: Controlling manufacturing parameters. Acta Biomater 2009;5:2540-2550.
– reference: Mochizuki M, Kadoya Y, Wakabayashi Y, Kato K, Okazaki I, Yamada M, Sato T, Sakairi N, Nishi N, Nomizu M. Laminin-1 peptide-conjugated chitosan membranes as a novel approach for cell engineering. FASEB J 2003;17:875-877.
– reference: Chung TW, Chang YL. Silk fibroin/chitosan-hyaluronic acid versus silk fibroin scaffolds for tissue engineering: promoting cell proliferations in vitro. J Mater Sci Mater Med 2010;21:1343-1351.
– reference: Cordon-Cardo C, Tapley P, Jing SQ, Nanduri V, O'Rourke E, Lamballe F, Kovary K, Klein R, Jones KR, Reichardt LF, Barbacid M. The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. Cell 1991;66:173-183.
– reference: Schmidt CE, Leach JB. Neural tissue engineering: Strategies for repair and regeneration. Ann Rev Biomed Eng 2003;5:293-347.
– reference: Madigan NN, McMahon S, O'Brien T, Yaszemski MJ, Windebank AJ. Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds. Respir Physiol Neurobiol 2009;169:183-199.
– reference: Sun M, Downes S. Physicochemical characterisation of novel ultra-thin biodegradable scaffolds for peripheral nerve repair. J Mater Sci Mater Med 2009;20:1181-1192.
– reference: Fujii DK, Massoglia SL, Savion N, Gospodarowicz D. Neurite outgrowth and protein synthesis by PC12 cells as a function of substratum and nerve growth factor. J Neurosci 1982;2:1157-1175.
– reference: Howe CL. Depolarization of PC12 cells induces neurite outgrowth and enhances nerve growth factor-induced neurite outgrowth in rats. Neurosci Lett 2003;351:41-45.
– reference: Chung TW, Yang MG, Liu DZ, Chen WP, Pan CI, Wang SS. Enhancing growth human endothelial cells on Arg-Gly-Asp (RGD) embedded poly (epsilon-caprolactone) (PCL) surface with nanometer scale of surface disturbance. J Biomed Mater Res A 2005;72:213-219.
– reference: Tucker BA, Rahimtula M, Mearow KM. Integrin activation and neurotrophin signaling cooperate to enhance neurite outgrowth in sensory neurons. J Comp Neurol 2005;486:267-280.
– reference: Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci 2001;24:1217-1281.
– volume: 10
  start-page: 95
  year: 2000
  end-page: 102
  article-title: Slit proteins: Key regulators of axon guidance, axonal branching, and cell migration
  publication-title: Curr Opin Neurobiol
– volume: 169
  start-page: 183
  year: 2009
  end-page: 199
  article-title: Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds
  publication-title: Respir Physiol Neurobiol
– volume: 252
  start-page: 554
  issue: 5005
  year: 1991
  end-page: 558
  article-title: The trk proto‐oncogene product: a signal transducing receptor for nerve growth factor
  publication-title: Science
– volume: 194
  start-page: 1
  issue: Pt 1
  year: 1999
  end-page: 14
  article-title: Peripheral nerve regeneration and neurotrophic factors
  publication-title: J Anat
– volume: 87
  start-page: 570
  year: 2008
  end-page: 579
  article-title: Development of a fibrin composite‐coated poly(epsilon‐caprolactone) scaffold for potential vascular tissue engineering applications
  publication-title: J Biomed Mater Res B Appl Biomater
– volume: 16
  start-page: 246
  year: 1991
  end-page: 250
  article-title: Arginyl‐glycyl‐aspartic acid (RGD): A cell adhesion motif
  publication-title: Trends Biochem Sci
– volume: 97
  start-page: 374
  year: 2004
  end-page: 377
  article-title: Immobilization of Arg‐Gly‐Asp (RGD) sequence in a thermosensitive hydrogel for cell delivery using pheochromocytoma cells (PC12)
  publication-title: J Biosci Bioeng
– volume: 81A
  start-page: 135
  year: 2007
  end-page: 149
  article-title: Nerve growth factor‐immobilized polypyrrole: Bioactive electrically conducting polymer for enhanced neurite extension
  publication-title: J Biomed Mater Res A
– volume: 72
  start-page: 213
  year: 2005
  end-page: 219
  article-title: Enhancing growth human endothelial cells on Arg‐Gly‐Asp (RGD) embedded poly (epsilon‐caprolactone) (PCL) surface with nanometer scale of surface disturbance
  publication-title: J Biomed Mater Res A
– volume: 20
  start-page: 1181
  year: 2009
  end-page: 1192
  article-title: Physicochemical characterisation of novel ultra‐thin biodegradable scaffolds for peripheral nerve repair
  publication-title: J Mater Sci Mater Med
– volume: 49
  start-page: 48
  year: 2005
  end-page: 64
  article-title: Tissue‐engineering approaches for axonal guidance
  publication-title: Brain Res Rev
– volume: 5
  start-page: 293
  year: 2003
  end-page: 347
  article-title: Neural tissue engineering: Strategies for repair and regeneration
  publication-title: Ann Rev Biomed Eng
– volume: 24
  start-page: 1217
  year: 2001
  end-page: 1281
  article-title: Nerve growth factor signaling, neuroprotection, and neural repair
  publication-title: Annu Rev Neurosci
– volume: 32
  start-page: 734
  year: 2011
  end-page: 743
  article-title: Promoting regeneration of peripheral nerves in‐vivo using new PCL‐ NGF/Tirofiban nerve conduits
  publication-title: Biomaterials
– volume: 11
  start-page: 1
  year: 2005
  end-page: 18
  article-title: Mediation of biomaterial‐cell interactions by adsorbed proteins: A review
  publication-title: Tissue Eng
– start-page: 11
  year: 2012
  article-title: Use new PLGL‐RGD‐NGF nerve conduits for promoting peripheral nerve regeneration
  publication-title: Biomed Eng Online
– volume: 66
  start-page: 173
  year: 1991
  end-page: 183
  article-title: The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin‐3
  publication-title: Cell
– volume: 26
  start-page: 151
  year: 2004
  end-page: 160
  article-title: Peripheral nerve regeneration through guidance tubes
  publication-title: Neurol Res
– volume: 486
  start-page: 267
  year: 2005
  end-page: 280
  article-title: Integrin activation and neurotrophin signaling cooperate to enhance neurite outgrowth in sensory neurons
  publication-title: J Comp Neurol
– volume: 351
  start-page: 41
  year: 2003
  end-page: 45
  article-title: Depolarization of PC12 cells induces neurite outgrowth and enhances nerve growth factor‐induced neurite outgrowth in rats
  publication-title: Neurosci Lett
– volume: 23
  start-page: 4803
  year: 2002
  end-page: 4809
  article-title: Growth of human endothelial cells on photochemically grafted Gly‐Arg‐Gly‐Asp (GRGD) chitosans
  publication-title: Biomaterials
– volume: 27
  start-page: 514
  year: 2010
  end-page: 520
  article-title: PCP copolymers grafted with RGD enhance the rates of RGD‐PCP micelles internalized into cells
  publication-title: J Microencapsul
– volume: 13
  start-page: 215
  year: 1997
  end-page: 225
  article-title: Historical and basic science review: Past, present, and future of nerve repair
  publication-title: J Reconstr Microsurg
– volume: 2
  start-page: 1157
  year: 1982
  end-page: 1175
  article-title: Neurite outgrowth and protein synthesis by PC12 cells as a function of substratum and nerve growth factor
  publication-title: J Neurosci
– volume: 21
  start-page: 1343
  year: 2010
  end-page: 1351
  article-title: Silk fibroin/chitosan‐hyaluronic acid versus silk fibroin scaffolds for tissue engineering: promoting cell proliferations in vitro
  publication-title: J Mater Sci Mater Med
– volume: 16
  start-page: 711
  year: 2003
  end-page: 715
  article-title: Biopolymers and biodegradable smart implants for tissue regeneration after spinal cord injury
  publication-title: Curr Opin Neurol
– volume: 17
  start-page: 875
  year: 2003
  end-page: 877
  article-title: Laminin‐1 peptide‐conjugated chitosan membranes as a novel approach for cell engineering
  publication-title: FASEB J
– volume: 82
  start-page: 842
  year: 2007
  end-page: 851
  article-title: Surface modification and characterization of chitosan or PLGA membrane with laminin by chemical and oxygen plasma treatment for neural regeneration
  publication-title: J Biomed Mater Res A
– volume: 8
  start-page: 3025
  year: 2007
  end-page: 3034
  article-title: Electroactive oligoaniline‐containing self‐assembled monolayers for tissue engineering applications
  publication-title: Biomacromolecules
– volume: 5
  start-page: 2540
  year: 2009
  end-page: 2550
  article-title: Diffusion of soluble factors through degradable polymer nerve guides: Controlling manufacturing parameters
  publication-title: Acta Biomater
– volume: 24
  start-page: 4655
  year: 2003
  end-page: 4661
  article-title: Enhancement of the growth of human endothelial cells by surface roughness at nanometer scale
  publication-title: Biomaterials
– volume: 24
  start-page: 677
  year: 2001
  end-page: 736
  article-title: Neurotrophins: roles in neuronal development and function
  publication-title: Ann Rev Neurosci
– volume: 30
  start-page: 4649
  year: 2009
  end-page: 4656
  article-title: The effect of collagen‐binding NGF‐beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model
  publication-title: Biomaterials
– ident: e_1_2_6_11_1
  doi: 10.1046/j.1469-7580.1999.19410001.x
– ident: e_1_2_6_21_1
  doi: 10.1016/S0142-9612(03)00361-2
– ident: e_1_2_6_17_1
  doi: 10.1016/j.biomaterials.2009.05.037
– ident: e_1_2_6_27_1
  doi: 10.1002/jbm.a.31036
– ident: e_1_2_6_29_1
  doi: 10.1016/j.actbio.2009.03.009
– ident: e_1_2_6_22_1
  doi: 10.1016/S1389-1723(04)70221-2
– ident: e_1_2_6_33_1
  doi: 10.1016/j.biomaterials.2010.09.023
– ident: e_1_2_6_8_1
  doi: 10.1016/j.resp.2009.08.015
– ident: e_1_2_6_16_1
  doi: 10.1016/S0304-3940(03)00915-7
– ident: e_1_2_6_2_1
  doi: 10.1016/j.brainresrev.2004.11.002
– ident: e_1_2_6_20_1
  doi: 10.1096/fj.02-0564fje
– ident: e_1_2_6_18_1
  doi: 10.1089/ten.2005.11.1
– ident: e_1_2_6_30_1
  doi: 10.1523/JNEUROSCI.02-08-01157.1982
– ident: e_1_2_6_3_1
  doi: 10.1016/S0959-4388(99)00066-5
– ident: e_1_2_6_13_1
  doi: 10.1146/annurev.neuro.24.1.1217
– ident: e_1_2_6_19_1
  doi: 10.1016/0968-0004(91)90096-E
– start-page: 11
  year: 2012
  ident: e_1_2_6_34_1
  article-title: Use new PLGL‐RGD‐NGF nerve conduits for promoting peripheral nerve regeneration
  publication-title: Biomed Eng Online
– ident: e_1_2_6_4_1
  doi: 10.1146/annurev.bioeng.5.011303.120731
– ident: e_1_2_6_26_1
  doi: 10.1007/s10856-009-3876-0
– ident: e_1_2_6_31_1
  doi: 10.3109/02652048.2010.484104
– ident: e_1_2_6_6_1
  doi: 10.1179/016164104225013798
– ident: e_1_2_6_9_1
  doi: 10.1002/jbm.a.30225
– ident: e_1_2_6_5_1
  doi: 10.1055/s-2007-1006407
– ident: e_1_2_6_32_1
  doi: 10.1002/cne.20518
– ident: e_1_2_6_23_1
  doi: 10.1021/bm070266z
– ident: e_1_2_6_24_1
  doi: 10.1016/S0142-9612(02)00231-4
– ident: e_1_2_6_28_1
  doi: 10.1007/s10856-008-3671-3
– ident: e_1_2_6_12_1
  doi: 10.1146/annurev.neuro.24.1.677
– ident: e_1_2_6_7_1
  doi: 10.1097/00019052-200312000-00011
– ident: e_1_2_6_15_1
  doi: 10.1126/science.1850549
– ident: e_1_2_6_14_1
  doi: 10.1016/0092-8674(91)90149-S
– ident: e_1_2_6_25_1
  doi: 10.1002/jbm.b.31146
– ident: e_1_2_6_10_1
  doi: 10.1002/jbm.a.31047
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Snippet Poly(ε‐caprolactone) (PCL) scaffolds functionalized by grafting nerve growth factor (NGF) and Asp‐Arg‐Gly‐Asp (GRGD)(PCL‐NGF/GRGD) for neural tissue...
Poly(ε-caprolactone) (PCL) scaffolds functionalized by grafting nerve growth factor (NGF) and Asp-Arg-Gly-Asp (GRGD)(PCL-NGF/GRGD) for neural tissue...
Poly([epsi]-caprolactone) (PCL) scaffolds functionalized by grafting nerve growth factor (NGF) and Asp-Arg-Gly-Asp (GRGD)(PCL-NGF/GRGD) for neural tissue...
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wiley
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Enrichment Source
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StartPage 315
SubjectTerms Animals
Biological and medical sciences
Biomaterials
Biotechnology
Cell Differentiation
Fundamental and applied biological sciences. Psychology
GRGD
Health. Pharmaceutical industry
Immobilized Proteins - chemistry
Industrial applications and implications. Economical aspects
Materials Testing
Medical sciences
Miscellaneous
Nerve Growth Factor - chemistry
Nerve Tissue - cytology
Nerve Tissue - metabolism
neural tissue engineering
Neurosurgery
NGF
Oligopeptides - chemistry
PC12 cell
PC12 Cells
PCL scaffolds
Polyesters - chemistry
Rats
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Synergistic effect
Technology. Biomaterials. Equipments
Tissue Engineering
Tissue Scaffolds - chemistry
Title Poly (ε-caprolactone) scaffolds functionalized by grafting NGF and GRGD promote growth and differentiation of PC12 cells
URI https://api.istex.fr/ark:/67375/WNG-1CQBQQ5R-4/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjbm.a.34693
https://www.ncbi.nlm.nih.gov/pubmed/23468336
https://www.proquest.com/docview/1766834295
https://www.proquest.com/docview/1477562019
Volume 102
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